Experiences with

Lupron

Currently on Lupron and keytruda. A second Foundation One DNA test showed high mutational burden with mmr 2 and 6, cdk 12 and pten loss. As a result his MO started him on keytruda. After first infusion PSA went from 37 to 105. ALP dropped 50 points.

P.S: He is currently on Xtandi, Lupron, Zometa, Rapaflo and painkillers.

(Gland removal in 2014, radiation and Lupron in 2017) PSA was .2 in April, .2 in May and .3 now in June. My MO says let it go above .5 so a scan may better locate the cells. He advises starting ADT now will put the tiger back to sleep before it can be found.

History: I have stage 4 PCa diagnosed 2.5 years ago and have had Docetaxel ( 5 sessions), Lupron (continuously), Zytiga ( failed), and now Xofigo( 3 sessions with monthly doubling PSA).

69, on lupron, xgeva, abiraterone and predisone. Psa less than 1.

My MO is suggesting Depo-Provera in response to my complaints about Lupron SEs. I'm a bit reluctant to take yet another 3-month shot, that can't be undone if I don't do well with its SEs . If you've tried it, what are your experiences?

Not wanting to play Russian roulette with cancer, I elected to have whole pelvic 40 SRT sessions and ADT treatment ( 6 mos Lupron with my testosterone at 469.4 ng/dL before injection). I finished my radiation about month ago and two weeks ago had ultra sensitive PSA and testosterone tests.

But my theory is that the joint pain could be due to the chemo, lupron, Zytiga, etc! So isn’t that really cancer pain? Some of those meds do deplete joint lubricant? Thank you for your suggestions!

Is the outcome from toxic drugs like Lupron (osteoporosis, high blood pressure, Parkinson, alzheimer, whatever else comes from long use of ADT) lessened by choosing physical castration?

My husband has been on 4 month Lupron since Jan 2021 and Abiraterone 1000mg since March. His original regimen was ordered for 2 years, but doesn't sound from what I read that it will be effective that long. Any feedback is appreciated. His PSA has gone from 51.3 in Dec 2020 to 0.3 in May..

They added a short course of Erleada and Zytiga to just 6 months of Lupron. I think they erred in not treating the pelvic lymph nodes. https://www.prostatecancer.news/2021/06/brief-intense-radiation-and-hormone.html

I have done falsodex and letozole along with lupron and xgeve. My onc says exemestane is next by in self but I’m thinking why if I have failed one AI already. I know that there are lots of more treatments but I feel like I’m not getting the best care.

After radical prostatectomy, clinical trial of chemo, and external beam radiation, the psa slowly rose until about 4 years ago, when I began Lupron injections. The psa went down, and has risen to a current 2.5. In a few weeks I will meet with my urologist and make a plan for the next treatment.

I've been on Abiraterone 250mg and Lupron 90 day inj's and Prednisone since Sept 2019. And Lupron injection again. Disappointed with: Weight gain and lack of total energy. Should I be persistent with my med oncologist June 8th on my 21 months of APC treatment? Or not?

This will be in conjunction with Lupron which started April 30th. I have a follow up appointment with the MO, Dr Suo on June 23rd with genetic testing bloodwork tomorrow am and follow up PSA every month for a year. Already on Lupron, the PSA 0.81 and the Testosterone is 2.2.

I joined proteus trial which is neo adjuvant use of apalutamide and lupron for 6 months, thenRP, then another 6 months of adjuvant therapy with the same protocol. My post RP cam as <0,006 which was good. I just got access to the post RP pathological report.

DX in 2017, G 5+4, had RP, did 37 Radiation, had BCR in 2019, been on Lupron since then. PSA is undetectable. Last Tuesday I woke to find my left leg swollen about a 1/4 larger than my right leg. Went to urgent care, Urinalyses normal, Kidney/Liver function normal .

Robotic, Lupron and Radiation on the checked list. I'm trying to stay "fit" but my former pleasant leisurely two mile stroll now feels like a 27 mile marathon where I hit the wall two minutes after leaving the house. My energy level non existent as my testosterone. The back pain constant.

Had a one month Lupron shot and dropped to 1.45 but in mid May was back up to 1.78. So here we go on the next step in this pathway. I had radiation and bracy boost in early 2016 with 24 months Lurpron. Back up psa in May 19; Casodex for a year then Eligard until this past Dec.

Going next week for my 6 month scan since last December when the psa was 15.5, since doing arbitrone with prednisone and xgeva and lupron, the psa is now at .7. If the psa drops why would they do a CT scan when the last one showed no disease progression.