Lu-177 switch from Xofigo. How long an interval?

[baltha]

Hello friends,

I have completed 3 Xofigo shots with the PSA doubling every month ( PSA 47 at present) & increasing bone mets, as per MRI.

I would like to switch to Lu-177. The nuclear medicine physician administering the Xofigo said I should wait six months to get the Xofigo out of my system before beginning another radio pharmaceutical (therefore Lu-177.) Is this true or just one opinion?

History: I have stage 4 PCa diagnosed 2.5 years ago and have had Docetaxel ( 5 sessions), Lupron (continuously), Zytiga ( failed), and now Xofigo( 3 sessions with monthly doubling PSA).

[Tall_Allen]

It depends on the trial you are looking at. Which trial? There are none in Oregon that I know of.

[baltha in reply to Tall_Allen]

Good question.

In reviewing my disappointing Xofigo numbers & MRIs, my oncologist brought up Lutetium as a possible next step . Nothing definite about where or when. When I find out more, I will get back. Thanks Allen.

Baltha

[baltha]

Really appreciate reading your deduction, Nalakrats.

The well-meaning nuclear medicine physician may have just been citing a generic ultra safe interval. I will look into this further & if I get credible info will report back.

[Nukepharmd]

Correct using half life formula. Rule of thumb is it takes 10 half lives to clear the body. Fyi for all of us.

[Hidden]

Try Jevtana while you’re waiting.