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Ribonucleic Acid (RNA) and its Role in Parkinson’s Disease (PD) and Levodopa-induced Dyskinesias
https://www.apdaparkinson.org/article/rna-research-krithy-irmady/
https://www.apdaparkinson.org/article/rna-research-krithy-irmady/
Farooqji
in
Cure Parkinson's
2 months ago
carbidopa, levodopa and anal/rectal pain
I know this might be a little bit of TMI for some of you, but I have to know if anyone of you out there has ever experienced severe anal/rectal pain from using carbidopa
levodopa
? Especially from the time you take it until the time it seems to start to work?
I know this might be a little bit of TMI for some of you, but I have to know if anyone of you out there has ever experienced severe anal/rectal pain from using carbidopa
levodopa
? Especially from the time you take it until the time it seems to start to work?
MissRita
in
Cure Parkinson's
1 year ago
Fast acting Levodopa?
My understanding is that
levodopa
needs to reach and be absorbed in the small intestine, so the drug needs much time to kick in. There are times however, when the
levodopa
is needed right away. Does anyone recall the post to have thoughts about getting
levodopa
absorbed faster?
My understanding is that
levodopa
needs to reach and be absorbed in the small intestine, so the drug needs much time to kick in. There are times however, when the
levodopa
is needed right away. Does anyone recall the post to have thoughts about getting
levodopa
absorbed faster?
Zardoz
in
Cure Parkinson's
1 year ago
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Phase 2b: Trial of Mesdopetam for Levodopa-induced Dyskinesia Nears End
https://parkinsonsnewstoday.com/news/trial-mesdopetam-
levodopa
-induced-dyskinesia-nears-end/ Mesdopetam is designed to block a dopamine receptor protein called D3 receptor, whose levels are increased in motor-related brain regions with prolonged
levodopa
treatment and associated dyskinesia.
https://parkinsonsnewstoday.com/news/trial-mesdopetam-
levodopa
-induced-dyskinesia-nears-end/ Mesdopetam is designed to block a dopamine receptor protein called D3 receptor, whose levels are increased in motor-related brain regions with prolonged
levodopa
treatment and associated dyskinesia.
Hidden
in
Cure Parkinson's
1 year ago
Interesting Gender Research Findings RE: Levodopa Absorption Rates
Another interesting finding by Contin et al (2022) found a 20% higher absorption of
levodopa
in patients treated with
levodopa
/benserazide versus
levodopa
/carbidopa formulation. These are all important findings for women with Parkinson's.
Another interesting finding by Contin et al (2022) found a 20% higher absorption of
levodopa
in patients treated with
levodopa
/benserazide versus
levodopa
/carbidopa formulation. These are all important findings for women with Parkinson's.
BeedieBird
in
Cure Parkinson's
1 year ago
Edited: PD increases chance of RLS.(yes) Azilect worsens RLS.(wrong) Ambroxol, being an antihistamine I believe worsens RLS.(incorrect)
Levodopa
increases augmentation meaning it makes RLS worse. So thinking Azilect does was not necessarily incorrect. If you have PD and develop RLS, well, it is horrid.
Levodopa
increases augmentation meaning it makes RLS worse. So thinking Azilect does was not necessarily incorrect. If you have PD and develop RLS, well, it is horrid.
Little_apple
in
Cure Parkinson's
1 year ago
How to reduce prolactin and increase AR success/longevity? L-Dopa and Vitex Berry?
Cabergoline reduces prolactin, which promotes prostate cancer mutation and growth. If a doctor will not prescribe Cabergoline, then would Mucuna (natural L-Dopa) extract and Vitex Berry extract have the same effectiveness as the cabergoline, in targeting and reducing prolactin? I recall someone on
Cabergoline reduces prolactin, which promotes prostate cancer mutation and growth. If a doctor will not prescribe Cabergoline, then would Mucuna (natural L-Dopa) extract and Vitex Berry extract have the same effectiveness as the cabergoline, in targeting and reducing prolactin? I recall someone on
GeorgeGlass
in
Advanced Prostate Cancer
1 year ago
COMT inhibitors
Hubby is doing really well at the moment and I think one of the things that has helped has been the introduction of 1/2 a entacapone tablet taken at the same time as his madopar/ mucuna doses. According to his genetic report his COMT appeared to be one thing that was functioning normally so I was a
Hubby is doing really well at the moment and I think one of the things that has helped has been the introduction of 1/2 a entacapone tablet taken at the same time as his madopar/ mucuna doses. According to his genetic report his COMT appeared to be one thing that was functioning normally so I was a
LAJ12345
in
Cure Parkinson's
1 year ago
Oh the pain…
Anyway, as
levodopa
wears off, it’s almost like my stomach hurts very deeply. Almost like kind of cramps. It’s not like the diarrhea cramps, but sometimes I do go. But I’m not sick or anything like that when it happens. TMI I know. But this is very painful.
Anyway, as
levodopa
wears off, it’s almost like my stomach hurts very deeply. Almost like kind of cramps. It’s not like the diarrhea cramps, but sometimes I do go. But I’m not sick or anything like that when it happens. TMI I know. But this is very painful.
Godiv
in
Cure Parkinson's
1 year ago
chatGPT's opinion on PD - Simple and wise
Here are some of the most common approaches to treating Parkinson's disease: Medications: There are several types of medications that can help manage the symptoms of Parkinson's disease, including
levodopa
, dopamine agonists, and MAO-B inhibitors.
Here are some of the most common approaches to treating Parkinson's disease: Medications: There are several types of medications that can help manage the symptoms of Parkinson's disease, including
levodopa
, dopamine agonists, and MAO-B inhibitors.
Xenos
in
Cure Parkinson's
1 year ago
levodopa
Hello, Does
Levodopa
help a person who Has symptoms of mild cognative impairment with early onset PD? TIA Steve
Hello, Does
Levodopa
help a person who Has symptoms of mild cognative impairment with early onset PD? TIA Steve
whiststev
in
Cure Parkinson's
1 year ago
The Effect of Curcumin on Idiopathic Parkinson Disease: A Clinical and Skin Biopsy Study
They showed a decrease of COMPASS-31 and NMSS scores, and a slight p-syn load decrease versus untreated patients who displayed a worsening of these parameters despite increased
levodopa
doses.
They showed a decrease of COMPASS-31 and NMSS scores, and a slight p-syn load decrease versus untreated patients who displayed a worsening of these parameters despite increased
levodopa
doses.
Bolt_Upright
in
Cure Parkinson's
1 year ago
Mucuna-Pruriens
https://www.nutrivitashop.com/l-dopa-100-pure-
levodopa
-mucuna-pruriens-dopamine/ I suggest people with stiffness and rigidity must try this. SPEAKING WITH PERSONAL EXPERIENCE good luck
https://www.nutrivitashop.com/l-dopa-100-pure-
levodopa
-mucuna-pruriens-dopamine/ I suggest people with stiffness and rigidity must try this. SPEAKING WITH PERSONAL EXPERIENCE good luck
sammytoronto93
in
Cure Parkinson's
11 months ago
High Dose Thiamine (HDT)—How critical is the sweet spot?
“or” I have gotten sloppy in my C/L routine: https://healthunlocked.com/cure-parkinsons/posts/147541603/how-i-went-from-13-to-4-a-day-carbidopa-25-
levodopa
-100 I wasn’t taking my L-dopa on an empty stomach (no eating 30 minutes before or 1 hour after).
“or” I have gotten sloppy in my C/L routine: https://healthunlocked.com/cure-parkinsons/posts/147541603/how-i-went-from-13-to-4-a-day-carbidopa-25-
levodopa
-100 I wasn’t taking my L-dopa on an empty stomach (no eating 30 minutes before or 1 hour after).
Gcf51
in
Cure Parkinson's
1 year ago
Negative levodopa
Where might negative
levodopa
be useful: - as we have seen, reducing
levodopa
induced dyskinesia; - response to mistakenly taking a double dose - as soon as you find the mistake eat protein; - smooth out the peaks in
levodopa
levels.
Where might negative
levodopa
be useful: - as we have seen, reducing
levodopa
induced dyskinesia; - response to mistakenly taking a double dose - as soon as you find the mistake eat protein; - smooth out the peaks in
levodopa
levels.
johntPM
in
Cure Parkinson's
1 year ago
Muhammad Ali and Young-Onset Idiopathic Parkinson Disease—The Missing Evidence
He was clearly responsive to
levodopa
, as documented in his several examinations in the early 1980s, a feature usually not present following traumatic brain injury."
He was clearly responsive to
levodopa
, as documented in his several examinations in the early 1980s, a feature usually not present following traumatic brain injury."
SilentEchoes
in
Cure Parkinson's
1 year ago
ibuprofen for PD
Occasionally I take Ibuprofen 400 mg once in a week or so and it fortifies the effects of
levodopa
by three times or higher. Wondering if there are any studies available on ibuprofen use for PD. Are there any negative side effects of its use for long ? Or long term positive effects for PD:
Occasionally I take Ibuprofen 400 mg once in a week or so and it fortifies the effects of
levodopa
by three times or higher. Wondering if there are any studies available on ibuprofen use for PD. Are there any negative side effects of its use for long ? Or long term positive effects for PD:
Farooqji
in
Cure Parkinson's
1 year ago
Insulin Resistance, Parkinson's Disease, Consequences And What To Do About It
This is particularly noteworthy for two reasons: One, the cornerstone of therapy for PD is the drug
levodopa
(also called L-dopa).
Levodopa
works by converting into dopamine and replenishing the brain's reduced supply; straight dopamine has difficulty crossing the blood/brain barrier.
This is particularly noteworthy for two reasons: One, the cornerstone of therapy for PD is the drug
levodopa
(also called L-dopa).
Levodopa
works by converting into dopamine and replenishing the brain's reduced supply; straight dopamine has difficulty crossing the blood/brain barrier.
chartist
in
Cure Parkinson's
1 year ago
choline/citicoline
https://www.naturalmedicinejournal.com/journal/citicoline-novel-therapeutic-agent-neuroprotective-neuromodulatory-and-neuroregenerative-properties I take a smallish dose but I suspect I need more- anyone using it successfully to make there L-dopa work better/last longer?
https://www.naturalmedicinejournal.com/journal/citicoline-novel-therapeutic-agent-neuroprotective-neuromodulatory-and-neuroregenerative-properties I take a smallish dose but I suspect I need more- anyone using it successfully to make there L-dopa work better/last longer?
Annieartist
in
Cure Parkinson's
1 year ago
Requested help for further training of neurologist
It was about the amount of
levodopa
. The carbidopa was only added because of possible nausea and stomach upset. Well, then you are speechless, whatever language you speak.
It was about the amount of
levodopa
. The carbidopa was only added because of possible nausea and stomach upset. Well, then you are speechless, whatever language you speak.
Esperanto
in
Cure Parkinson's
1 year ago
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