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Levodopa / Carbidopa / Entacapone
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Is anyone concerned about aspartame in the carbidopa-levodopa?
Is there a form of Carbidopa levodopa that does not have aspartame in it?
Is there a form of Carbidopa levodopa that does not have aspartame in it?
Smittybear7
in
Cure Parkinson's
2 years ago
Parkinson’s and eyes
Yesterday, I had an eye test and my vision has improved. This is great but I spent a lot of money on some new glasses last year because my vision and had declined. I have poor eyesight and wear complex lenses. Looking at the times of each eye test, last years was done first thing in the morning and
Yesterday, I had an eye test and my vision has improved. This is great but I spent a lot of money on some new glasses last year because my vision and had declined. I have poor eyesight and wear complex lenses. Looking at the times of each eye test, last years was done first thing in the morning and
forest1
in
Cure Parkinson's
2 years ago
video: Design of the EPSILON trial of opicapone as an add-on to levodopa in early PD
https://www.youtube.com/watch?v=LA6CdWs6Y1w
https://www.youtube.com/watch?v=LA6CdWs6Y1w
Hidden
in
Cure Parkinson's
2 years ago
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dyskinesia and dystonia
hello Am I right that dyskinesia (involuntary movement) of eg mouth and tongue may be caused by either PD symptoms getting worse or a side effect of L-Dopa medication? How do you know which it is? Could someone provide me with a lay person’s definition of the difference between dystonia and dyskinesia
hello Am I right that dyskinesia (involuntary movement) of eg mouth and tongue may be caused by either PD symptoms getting worse or a side effect of L-Dopa medication? How do you know which it is? Could someone provide me with a lay person’s definition of the difference between dystonia and dyskinesia
Tomkins
in
Cure Parkinson's
2 years ago
Levodopa and food: slows uptake but gives you more in the long run?
According to FDA prescribing information: "In healthy adults, oral administration of Rytary after a high-fat, high-calorie meal reduced Cmax approximately 21% and increased AUCinf approximately 13% for levodopa compared to administration in the fasted state. There may be a delay by 2 hours in the absorption
According to FDA prescribing information: "In healthy adults, oral administration of Rytary after a high-fat, high-calorie meal reduced Cmax approximately 21% and increased AUCinf approximately 13% for levodopa compared to administration in the fasted state. There may be a delay by 2 hours in the absorption
johntPM
in
Cure Parkinson's
2 years ago
PS128 Again in the News
https://parkinsonsnewstoday.com/sponsored-content/3-reasons-to-consider-a-daily-probiotic-supplement-for-parkinsons/ 1/ Gut health probiotics for constipation Constipation and other gastrointestinal problems are very common non-motor symptoms of PD. Fortunately, many strains of probiotic bacteria can
https://parkinsonsnewstoday.com/sponsored-content/3-reasons-to-consider-a-daily-probiotic-supplement-for-parkinsons/ 1/ Gut health probiotics for constipation Constipation and other gastrointestinal problems are very common non-motor symptoms of PD. Fortunately, many strains of probiotic bacteria can
Baron1
in
Cure Parkinson's
2 years ago
PSP and Macuna
Hi does Macuna help in PSP related symptoms though lot of articles state that L-DOPA is ineffective for PSP but works for Parkinson's
Hi does Macuna help in PSP related symptoms though lot of articles state that L-DOPA is ineffective for PSP but works for Parkinson's
Seeker_12
in
PSP Association
2 years ago
Scientists Uncover One of the Driving Forces of Alzheimer’s Disease (applicable to PD) – New Target for Treatment
https://scitechdaily.com/scientists-uncover-one-of-the-driving-forces-of-alzheimers-disease-new-target-for-treatment/ "New research explored how a protein called tau, critical to Alzheimer’s, turns from normal to a diseased state. This discovery presents a new target to potentially prevent or treat
https://scitechdaily.com/scientists-uncover-one-of-the-driving-forces-of-alzheimers-disease-new-target-for-treatment/ "New research explored how a protein called tau, critical to Alzheimer’s, turns from normal to a diseased state. This discovery presents a new target to potentially prevent or treat
PDWarrior1900
in
Cure Parkinson's
2 years ago
video from 2021, Living Your Best Life with PD, different approaches to therapy
I like how they do not recommend levodopa usage only https://youtu.be/xULVEeBt0aw?t=1907
I like how they do not recommend levodopa usage only https://youtu.be/xULVEeBt0aw?t=1907
Hidden
in
Cure Parkinson's
2 years ago
Parkinson's PLUS +
I am trying to determine if a person diagnosed long ago with P.D. who found relief by taking PD medication can develop Progressive Supranuclear Palsy. I had a friend that was diagnosed with PD a bit later than me and the PD medication helped him but not as much as it helped me. Later years he was
I am trying to determine if a person diagnosed long ago with P.D. who found relief by taking PD medication can develop Progressive Supranuclear Palsy. I had a friend that was diagnosed with PD a bit later than me and the PD medication helped him but not as much as it helped me. Later years he was
Gymsack
in
Cure Parkinson's
2 years ago
Why do I have to take levodopa so frequently?
Short answer: Once levodopa gets into your bloodstream (after being absorbed in your digestive tract), it doesn’t last long … most of it is gone after about 2-3 hours, and then you need to take more. The resulting rapid oscillations in blood levels of the drug are responsible for both on-off cycling
Short answer: Once levodopa gets into your bloodstream (after being absorbed in your digestive tract), it doesn’t last long … most of it is gone after about 2-3 hours, and then you need to take more. The resulting rapid oscillations in blood levels of the drug are responsible for both on-off cycling
Thal
in
Cure Parkinson's
2 years ago
Parkinson’s and Protein
“I explored diets and after realizing I was generally doing worse if I ate a lot of meat, I looked into vegetarian diets…. What a difference it makes for me.” —GAIL J., PWP You may have heard about protein being a no-no in the Parkinson’s diet. This is only partially true. The problem is that because
“I explored diets and after realizing I was generally doing worse if I ate a lot of meat, I looked into vegetarian diets…. What a difference it makes for me.” —GAIL J., PWP You may have heard about protein being a no-no in the Parkinson’s diet. This is only partially true. The problem is that because
Farooqji
in
Cure Parkinson's
2 years ago
Getting the Most Out of Medications
“My husband has Parkinson’s, and we just got a new doctor a couple of months ago. Bob has been taking Sinemet ever since he was diagnosed. He always takes his meds first thing in the morning, then eats his breakfast. He has not been doing very well for some time…. Anyway, the doctor told him NOT to
“My husband has Parkinson’s, and we just got a new doctor a couple of months ago. Bob has been taking Sinemet ever since he was diagnosed. He always takes his meds first thing in the morning, then eats his breakfast. He has not been doing very well for some time…. Anyway, the doctor told him NOT to
Farooqji
in
Cure Parkinson's
2 years ago
PD Effect on Sleep
“My wife had trouble sleeping due to restless legs and being awakened by vivid and disturbing nightmares. Fortunately, this condition seems to have been fixed with a prescription from the neurologist. The clonazepam pills have all but eliminated that problem.” —ED C., PARKINSON’S CAREGIVER It is common
“My wife had trouble sleeping due to restless legs and being awakened by vivid and disturbing nightmares. Fortunately, this condition seems to have been fixed with a prescription from the neurologist. The clonazepam pills have all but eliminated that problem.” —ED C., PARKINSON’S CAREGIVER It is common
Farooqji
in
Cure Parkinson's
2 years ago
When Anxiety Strikes
“One [thing] I have learned is to live for the day and the moment rather than looking back to the past or worrying about the future. I also have discovered that it is best to live within my limitations—to step back and take things easy if I’m having a bad day. Otherwise I only find myself frustrated
“One [thing] I have learned is to live for the day and the moment rather than looking back to the past or worrying about the future. I also have discovered that it is best to live within my limitations—to step back and take things easy if I’m having a bad day. Otherwise I only find myself frustrated
Farooqji
in
Cure Parkinson's
2 years ago
Adrenaline dominance
https://theenergyblueprint.com/adrenaline-dominance-dr-michael-platt/ This is kind of interesting and a different theory. This doctor believes adrenaline is the root cause of many problems. I think it’s interesting because dopamine is broken down by beta hydroxylase to norepinephrine then by PNMT to
https://theenergyblueprint.com/adrenaline-dominance-dr-michael-platt/ This is kind of interesting and a different theory. This doctor believes adrenaline is the root cause of many problems. I think it’s interesting because dopamine is broken down by beta hydroxylase to norepinephrine then by PNMT to
LAJ12345
in
Cure Parkinson's
2 years ago
Finding some negatives on Berberine (I will keep digging)
EDIT March 17, 2024:
Today somebody shared a link to a two year old post of mine about a report on Berberine being neurotoxic and taking it off of my stack. Within a few months I found other information on Berberine and, using my High School educated brain, decided that Berberine definitely needed
EDIT March 17, 2024:
Today somebody shared a link to a two year old post of mine about a report on Berberine being neurotoxic and taking it off of my stack. Within a few months I found other information on Berberine and, using my High School educated brain, decided that Berberine definitely needed
Bolt_Upright
in
Cure Parkinson's
2 years ago
Phosphodiesterase 9 inhibition prolongs the antiparkinsonian action of l-DOPA in parkinsonian non-human primates
https://pubmed.ncbi.nlm.nih.gov/35461880/ These results indicate that cGMP upregulation interacts with dopamine signaling to enhance the l-DOPA reversal of parkinsonian motor disability. Therefore, striatal PDE9 inhibition may be further explored as a strategy to improve motor responses to l-DOPA in
https://pubmed.ncbi.nlm.nih.gov/35461880/ These results indicate that cGMP upregulation interacts with dopamine signaling to enhance the l-DOPA reversal of parkinsonian motor disability. Therefore, striatal PDE9 inhibition may be further explored as a strategy to improve motor responses to l-DOPA in
Hidden
in
Cure Parkinson's
2 years ago
GABA and PD
https://www.frontiersin.org/articles/10.3389/fneur.2018.00806/full Discussion Gait and locomotion, turning in bed, arising from a chair, and postural stability all depend on efficient sensorimotor integration (28, 29), which is affected in PD (30–32). The basal ganglia act as an important hub for sensorimotor
https://www.frontiersin.org/articles/10.3389/fneur.2018.00806/full Discussion Gait and locomotion, turning in bed, arising from a chair, and postural stability all depend on efficient sensorimotor integration (28, 29), which is affected in PD (30–32). The basal ganglia act as an important hub for sensorimotor
LAJ12345
in
Cure Parkinson's
2 years ago
Maybe why we wait for a cure
I think I may have previously posted some of this story My first Neurologist was a brilliant doctor and brain surgeon and expert in the cardiovascular system. He was head of cardiology at a world class hospital and known around the world. My M.D. went to school with him and they were good friends
I think I may have previously posted some of this story My first Neurologist was a brilliant doctor and brain surgeon and expert in the cardiovascular system. He was head of cardiology at a world class hospital and known around the world. My M.D. went to school with him and they were good friends
Gymsack
in
Cure Parkinson's
2 years ago
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