PwP, Glaucoma and Citicoline

[chartist]

Previously I posted about the usefulness of Citicoline for memory issues here:

healthunlocked.com/cure-par...

Here is a review that gives a good idea of the benefits of citicoline in PwP:

researchgate.net/publicatio...

Conclusion of the review:

' Despite the varied outcome tools, this review found that patients with PD who were taking citicoline had significant improvement in rigidity, akinesia, tremor, handwriting, and speech. Citicoline allowed effective reduction of levodopa by up to 50%. Significant improvement in cognitive status evaluation was also noted with citicoline adjunctive therapy. Implications Citicoline adjuvant therapy has beneficial effects as an adjuvant therapy in patients with PD.'

In the following study it is stated that PwP are at increased risk for glaucoma :

omicsonline.org/open-access...

Here is a relevant quote from the study :

>>> ' Results: The frequency of glaucoma was higher in eyes of PD patients in comparison to controls (16.33% vs.

6.63%; p=0.004) and intraocular pressure was significantly lower (16.88 ± 3.18 vs. 17.76 ± 3.21 mm Hg; p=0.009).

Systolic and diastolic blood pressure, as well as calculated perfusion pressures did not differ significantly between

PD and control group with exception of higher diastolic perfusion pressure in PD patients’ eyes. The retinal fiber layer

thickness did not significantly differ between investigated no-glaucoma groups, but revealed significant reduction in

superior and inferior quadrant in glaucoma PD patients.

Conclusion: PD patients have increased risk of glaucoma. ' >> ' CONCLUSION

With oral citicoline treatment, the loss in the average RNFL is prevented in POAG patients in the short-term. Study data show that citicoline may have a significant impact on slowing glaucoma progression, which could have a potential neuroprotective effect. ' <<<

As you can see, newer studies continue to uncover the full usefulness of Citicoline in PD and PD related health issues.

Art

[Lizzy9]

Hello Art ~ Do you think TruNiagen would be as effective as citicoline in this case?

Thank you for you investigating this!!

Gail

[chartist in reply to Lizzy9]

Possibly, but there are not heads up studies between the two to determine which is more effective. Citicoline offers multiple benefits as TruNiagen does, so in some ways they are comparable. I assume you are asking to see which would be the better choice for you and I imagine that will come down to which one has the better studies to support all of the uses that you would be using these two for.

On a somewhat related note vitamin B3 in the form of nicotinamide/niacinamide also offers anti-glaucoma effects inexpensively.

nutraingredients-usa.com/Ar...

Art

[Lizzy9 in reply to chartist]

Thank you for this information!! I wonder if I could give him both, TruNiagen and a nicotinamide/niacinamide??

Thank you for your help and insights!

[chartist in reply to Lizzy9]

Nicotinamide /niacinamide is also a NAD+ precursor so it may be additive to TruNiagen in that effect if that is what you are trying to do it may be worth looking into further.

Art

[Hidden in reply to chartist]

An additional consideration is that niacin (not as NR or NMN) depletes methylation stores more than supplementing with NR. But even with NR, supplementing with Betaine / TMG to restore methylation is a good idea. I recently read that replenishing creatine is a good idea as well given how much is used up in methylation. (My laymen terms are not doing this subject justice)

[Despe in reply to Hidden]

You are a fast learner, CC.

😀

[Despe in reply to Despe]

"An additional consideration is that niacin (not as NR or NMN) depletes methylation stores more than supplementing with NR."

Would you please provide a study/link for your statement. Thank you.

[Hidden in reply to Despe]

At about 1 hour 9 minutes he discusses NAD

youtu.be/lv7ihoY8XyA(Not working as expected?)

More info on his site

chrismasterjohnphd.com/

And thank you Despe! 🌷

[Despe in reply to Hidden]

Very interesting site! I thank you, CC. Added it to my bookmarks for further studying.

[Lizzy9 in reply to chartist]

Thank you! I will look further into Nicotinamide /niacinamide in addition to TruNiagen.

Blessings and have a fabulous day!

[Smittybear7]

Thanks for the information!

[MBAnderson]

Thanks Art.

[chartist in reply to MBAnderson]

Hi Marc,

I haven't seen you around much, how are you doing after the surgery and a little time?

Art

[MBAnderson in reply to chartist]

Art,

I'm here -- keeping an eye on you all.

Back pain has subsided considerably in the past couple days, thank you for asking. Staples came out yesterday.

Marc

[chartist in reply to MBAnderson]

Very good to hear of your improvement, Marc!

Art

[Hidden in reply to MBAnderson]

Hi Marc, I was reading about something that might (emphasis on might) be of help with your back pain.

Specialized Pro Resolving Mediators

I posted about it with a link to the brand recommended by Dr. Chris Masterjohn

[MBAnderson in reply to Hidden]

Thank you, cc. I'll look into it.

[Fumaniron]

Excellent. What is the maximal daily dosage of cdp choline? I take 750mg a day. I believe I read of possible risks of going too high…

[chartist in reply to Fumaniron]

The highest dosage of Citicoline I have seen in a study is 2 grams per day used in a study where they were trying to help people reduce their craving for methamphetamine. In the study I referenced, they used 250 mg/day.

Art

[chartist]

Here is another study adding further confirmation to the usefulness of Citicoline for glaucoma. The full study is available in German :

pubmed.ncbi.nlm.nih.gov/337....

Art

[Fumaniron]

Thanks, Chartist!

[Zardoz]

I've been revisiting some years old posts by kia17 and for us rigid type PWP's it seems that choline is not recommended.

healthunlocked.com/cure-par...

[chartist in reply to Zardoz]

Zardoz,

Citicoline is considered to be more desirable than choline for the purpose of use in PD.

This systematic review suggests Citicoline is useful for rigidity improvement and much more :

clinicaltherapeutics.com/ar...

Here is a relevant quote from the review :

>>> ' A total of 7 studies (2 crossover, 3 randomized controlled, and 2 open prospective studies) were included. Despite the varied outcome tools, this review found that patients with PD who were taking citicoline had significant improvement in rigidity, akinesia, tremor, handwriting, and speech. Citicoline allowed effective reduction of levodopa by up to 50%. Significant improvement in cognitive status evaluation was also noted with citicoline adjunctive therapy. ' <<<

Add in the anti glaucoma effects and memory improving effects and citicoline seems useful for PwP.

What PwP doesn't want these type of benefits?

Art

[Zardoz in reply to chartist]

thanks for that info

[chartist in reply to Zardoz]

There are quite a few studies to add confirmation to these many benefits from Citicoline for PD and glaucoma.

Art

[JCRO in reply to chartist]

apple.news/AiyrwnJuDRK68wT8...

[JCRO in reply to JCRO]

Dopamine signaling is a highly complex process, and one that scientists are eager to understand—especially given its role in movement disorders such as Parkinson's disease. Now, a team at Harvard Medical School has identified a new mechanism that underlies dopamine release in the brain. The research, conducted in mice and published March 24 in Science, shows that another chemical messenger called acetylcholine can trigger the firing of dopamine neurons by binding to a part of these neurons not previously known to initiate firing.

[chartist in reply to JCRO]

Very interesting findings, especially since acetylcholine levels are known to be low in PD and AD. Citicoline has been shown to increase acetylcholine in the brain. Most newer data suggests that Citicoline is the better option to choline since it has a hypothesized lower conversion to TMA and TMAO . TMAO is considered to be a promoter of atherosclerosis which we definitely don't need. Newer research also suggests higher efficacy over choline.

Art

[JCRO in reply to chartist]

Has anyone seen any updates to use of citicholine in 2023? I’m stiffness dominant really and suffering with vMCI that I could well do without. Thx.

[chartist in reply to JCRO]

Regarding the vascular mild cognitive impairment vMCI, there is this February 2023 article discussing the benefits of Citicoline for vMCI :

ncbi.nlm.nih.gov/pmc/articl...

Also, I wrote this awhile back that may be useful for MCI & vMCI :

healthunlocked.com/cure-par...

Art

[JCRO in reply to chartist]

I meant very mild cognitive impairment. Sorry for confusion. 🤣