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Experiences with
Levodopa / Carbidopa / Entacapone
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Success with Adderall dependence and changing medications?
Anyone have any luck changing medications while dependent on Adderall? If so, how did you do it and what if any supplements did you use? Even if it was just quitting altogether, that can be helpful too. I am not addicted, but I am definitely dependent on Adderall. Like many others. The chance to stop
Anyone have any luck changing medications while dependent on Adderall? If so, how did you do it and what if any supplements did you use? Even if it was just quitting altogether, that can be helpful too. I am not addicted, but I am definitely dependent on Adderall. Like many others. The chance to stop
HCStymie
in
CHADD's Adult ADHD Support
1 year ago
GABA Nutrientsupplement vs Gabapentin and other Prescription Drugs of the same order
I have had RLS for about 6 years. The first medication was Levodopa 100mg as usual. After about 2 years it didn‘t do anything for me anymore. My new medication was Pramipexol 0.088 mg, which for 6 months worked OK. Then continuesly insomnia set in and I was sleeping or better just dosing off for 1-2
I have had RLS for about 6 years. The first medication was Levodopa 100mg as usual. After about 2 years it didn‘t do anything for me anymore. My new medication was Pramipexol 0.088 mg, which for 6 months worked OK. Then continuesly insomnia set in and I was sleeping or better just dosing off for 1-2
Ohmg
in
Restless Legs Syndrome
1 year ago
Insulin Resistance, Parkinson's Disease, Consequences And What To Do About It
The topic of insulin resistance (IR) in PwP is not often discussed. Has your MDS or neurologist ever tested you for IR? It is estimated that two thirds of people with PD who are not diabetic, have IR and very likely are not even aware they have IR as discussed here : https://www.parkinson.org/blog/
The topic of insulin resistance (IR) in PwP is not often discussed. Has your MDS or neurologist ever tested you for IR? It is estimated that two thirds of people with PD who are not diabetic, have IR and very likely are not even aware they have IR as discussed here : https://www.parkinson.org/blog/
chartist
in
Cure Parkinson's
1 year ago
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Real-world evidence on levodopa dose escalation in patients with Parkinson’s disease treated with istradefylline (Nourianz)
Interesting article. Nourianz is an add-on drug for PD, not covered by many insurance companies or Medicare in US, super $$$. However, because of a patent dispute,[i] Nourianz will be eligible for patent challenges on August 27, 2023. This date may extended up to six months if a pediatric exclusivity
Interesting article. Nourianz is an add-on drug for PD, not covered by many insurance companies or Medicare in US, super $$$. However, because of a patent dispute,[i] Nourianz will be eligible for patent challenges on August 27, 2023. This date may extended up to six months if a pediatric exclusivity
Sydney75
in
Cure Parkinson's
1 year ago
DBS and Sinemet
I had the DBS surgery last October. After DBS, Sinemet made my PD symptoms worse...especially balance (It's like I am constantly falling forward and my legs are trying to keep up). I told my neurologist about it and she thought is odd that Sinemet would do that. I feel better without the Sinemet.
I had the DBS surgery last October. After DBS, Sinemet made my PD symptoms worse...especially balance (It's like I am constantly falling forward and my legs are trying to keep up). I told my neurologist about it and she thought is odd that Sinemet would do that. I feel better without the Sinemet.
DeanGreen
in
Cure Parkinson's
1 year ago
Curcumin Update 2023/03/06
I'm trying to get more organized so any post on a topic will include everything relevant to that topic in one post. So, for instance, future curcumin posts will be updates of this post:
Curcumin Update 2023/03/06
Last Updated:
2023/03/06 [u]
Status: In my stack as of 2023/03/05[/b
I'm trying to get more organized so any post on a topic will include everything relevant to that topic in one post. So, for instance, future curcumin posts will be updates of this post:
Curcumin Update 2023/03/06
Last Updated:
2023/03/06 [u]
Status: In my stack as of 2023/03/05[/b
Bolt_Upright
in
Cure Parkinson's
1 year ago
Stopping Azilect to change to Macuna? I need help.
Dopamine agonists worsen RLS over time (proven) and I believe in my case may have caused it. Finding this out has changed my opinion of Azilect. I was hopeful it might be Neuroprotective because of it being a Mao-B inhibitor but, it’s causing worsened RLS is the antithesis of Neuroprotective. (On a
Dopamine agonists worsen RLS over time (proven) and I believe in my case may have caused it. Finding this out has changed my opinion of Azilect. I was hopeful it might be Neuroprotective because of it being a Mao-B inhibitor but, it’s causing worsened RLS is the antithesis of Neuroprotective. (On a
Little_apple
in
Cure Parkinson's
1 year ago
advice please
hi, new to this group. Had a walking problem since 2018, wobbly, balance bad, felt uneven, stairs worse- legs go weak! Left foot turns out. Can set off ok ish then seconds later I’m shuffling. Not in pain. Going round in circles for last 4 years ( neurologists not giving diagnosis) seen one this past
hi, new to this group. Had a walking problem since 2018, wobbly, balance bad, felt uneven, stairs worse- legs go weak! Left foot turns out. Can set off ok ish then seconds later I’m shuffling. Not in pain. Going round in circles for last 4 years ( neurologists not giving diagnosis) seen one this past
Judiy
in
Functional Neurological Disorder - FND Hope
2 years ago
Vagal Nerve Stimulation (tVNS) Research Summary
Some definitions for clarity. Neuromodulation, stimulating nerves (usually with electricity) to change (hopefully improve) or control their function. Deep Brain Stimulation (DBS) is a form of neuromodulation. Neuromodulation can be invasive, requiring surgery (like DBS) or noninvasive which provides
Some definitions for clarity. Neuromodulation, stimulating nerves (usually with electricity) to change (hopefully improve) or control their function. Deep Brain Stimulation (DBS) is a form of neuromodulation. Neuromodulation can be invasive, requiring surgery (like DBS) or noninvasive which provides
House2
in
Cure Parkinson's
1 year ago
IRL1117, Potential Improvement on Levodopa, May Enter Clinical Trial
IRLAB Therapeutics has selected a dopamine receptor agonist candidate called IRL1117 to advance as a Parkinson’s disease treatment, potentially as a longer-lasting alternative to levodopa with lesser side effects. IRL1117 is designed to be a once-daily oral therapy for the hallmark symptoms of Parkinson
IRLAB Therapeutics has selected a dopamine receptor agonist candidate called IRL1117 to advance as a Parkinson’s disease treatment, potentially as a longer-lasting alternative to levodopa with lesser side effects. IRL1117 is designed to be a once-daily oral therapy for the hallmark symptoms of Parkinson
Farooqji
in
Cure Parkinson's
1 year ago
I don't know what this Melatonin blurb is trying to say
From this article: Antioxidants and Prooxidants: Effects on Health and Aging 2020 https://www.hindawi.com/journals/omcl/2020/2360872/ This line: [u]
In addition, administration of melatonin to humans promoted reduction of COX-2 activity, nitrites and nitrates, and lipid peroxides that correlated with
From this article: Antioxidants and Prooxidants: Effects on Health and Aging 2020 https://www.hindawi.com/journals/omcl/2020/2360872/ This line: [u]
In addition, administration of melatonin to humans promoted reduction of COX-2 activity, nitrites and nitrates, and lipid peroxides that correlated with
Bolt_Upright
in
Cure Parkinson's
1 year ago
“The three amino acids that are most effective at increasing dopamine levels are l-tyrosine, L-dopa, and phenylalanine.”
Anyone using these in combination? I think adding SAM-e to this might work synergistically? I’m learning other means of increasing dopamine to wean off of Azilect.
Anyone using these in combination? I think adding SAM-e to this might work synergistically? I’m learning other means of increasing dopamine to wean off of Azilect.
Little_apple
in
Cure Parkinson's
1 year ago
Edited: PD increases chance of RLS.(yes) Azilect worsens RLS.(wrong) Ambroxol, being an antihistamine I believe worsens RLS.(incorrect)
Edited to state that: I was wrong! Editing my edit: (yes, I know, but I’m trying) Not only do dopamine agonists make RLS worse but so do meds that increase dopamine. Azilect was not mentioned specifically but increasing dopamine is a “cause of RLS augmentation.” Levodopa increases augmentation meaning
Edited to state that: I was wrong! Editing my edit: (yes, I know, but I’m trying) Not only do dopamine agonists make RLS worse but so do meds that increase dopamine. Azilect was not mentioned specifically but increasing dopamine is a “cause of RLS augmentation.” Levodopa increases augmentation meaning
Little_apple
in
Cure Parkinson's
1 year ago
High Dose Thiamine (HDT)—How critical is the sweet spot?
High Dose Thiamine (HDT)—How critical is the sweet spot? How critical is the sweet spot? If mine is 1200mg oral Thiamine HCL a day and I took 1100mg for 10 days, should it make a difference? I am currently at 118 days at a value less than 1300 and greater than 1100. I think, I might have misjudged a
High Dose Thiamine (HDT)—How critical is the sweet spot? How critical is the sweet spot? If mine is 1200mg oral Thiamine HCL a day and I took 1100mg for 10 days, should it make a difference? I am currently at 118 days at a value less than 1300 and greater than 1100. I think, I might have misjudged a
Gcf51
in
Cure Parkinson's
1 year ago
Requested help for further training of neurologist
My introduction to the new neurologist was rather disappointing. Apart from the fact that he did not even make any attempt to come across as somewhat understanding and social, this person again lacked constructive thinking about possible improvements to the PD and PN (peripheral neuropathy) situation
My introduction to the new neurologist was rather disappointing. Apart from the fact that he did not even make any attempt to come across as somewhat understanding and social, this person again lacked constructive thinking about possible improvements to the PD and PN (peripheral neuropathy) situation
Esperanto
in
Cure Parkinson's
1 year ago
Ketogenic Diet Parkinson's
Parkinson’s disease (PD) is a frequently observed neurodegenerative disease of the brain, the incidence of which has doubled since 1990. It develops particularly in elderly people, namely, in 1% of individuals aged over 60 years, although it is increasingly diagnosed in persons at a young age. It is
Parkinson’s disease (PD) is a frequently observed neurodegenerative disease of the brain, the incidence of which has doubled since 1990. It develops particularly in elderly people, namely, in 1% of individuals aged over 60 years, although it is increasingly diagnosed in persons at a young age. It is
House2
in
Cure Parkinson's
1 year ago
chatGPT's opinion on PD - Simple and wise
Unfortunately, there is no cure for Parkinson's disease, but there are several treatments available that can help manage the symptoms and improve quality of life. Here are some of the most common approaches to treating Parkinson's disease: Medications: There are several types of medications that
Unfortunately, there is no cure for Parkinson's disease, but there are several treatments available that can help manage the symptoms and improve quality of life. Here are some of the most common approaches to treating Parkinson's disease: Medications: There are several types of medications that
Xenos
in
Cure Parkinson's
1 year ago
The Effect of Curcumin on Idiopathic Parkinson Disease: A Clinical and Skin Biopsy Study
Looks like I am adding Curcumin back to my stack (which is good as I have a lot of it!): The Effect of Curcumin on Idiopathic Parkinson Disease: A Clinical and Skin Biopsy Study 2022 https://academic.oup.com/jnen/article/81/7/545/6585246 "Abstract There are currently no standardized therapies for Parkinson
Looks like I am adding Curcumin back to my stack (which is good as I have a lot of it!): The Effect of Curcumin on Idiopathic Parkinson Disease: A Clinical and Skin Biopsy Study 2022 https://academic.oup.com/jnen/article/81/7/545/6585246 "Abstract There are currently no standardized therapies for Parkinson
Bolt_Upright
in
Cure Parkinson's
1 year ago
Health update
Hello everyone, not sure if this helps... I went through genetic testing and they found my KMT2B gene activated. This is odd due to my age and how aggresive it is. My Dr has never seen this happen before. In actuality, there is nothing in written human history (as far as I know) that shows late stage
Hello everyone, not sure if this helps... I went through genetic testing and they found my KMT2B gene activated. This is odd due to my age and how aggresive it is. My Dr has never seen this happen before. In actuality, there is nothing in written human history (as far as I know) that shows late stage
Hidden
in
Functional Neurological Disorder - FND Hope
1 year ago
Treating PD with levodopa combined with tetracycline (Effects of levodopa on gut bacterial antibiotic resistance in Parkinson’s disease rat)
The combination of levodopa and antibiotics, such as tetracycline and vancomycin, in the treatment of PD may decrease the amount of corresponding antibiotic resistance genes in gut bacteria, which would give a theoretical basis for treating PD with levodopa combined with tetracycline and vancomycin in
The combination of levodopa and antibiotics, such as tetracycline and vancomycin, in the treatment of PD may decrease the amount of corresponding antibiotic resistance genes in gut bacteria, which would give a theoretical basis for treating PD with levodopa combined with tetracycline and vancomycin in
Farooqji
in
Cure Parkinson's
1 year ago
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