Looks like I am adding Curcumin back to my stack (which is good as I have a lot of it!): The Effect of Curcumin on Idiopathic Parkinson Disease: A Clinical and Skin Biopsy Study 2022 academic.oup.com/jnen/artic...
"Abstract
There are currently no standardized therapies for Parkinson disease (PD). Curcumin shows anti-amyloidogenic properties in vitro and may be a promising treatment for PD. We evaluated the effects of curcumin supplementation on clinical scales and misfolded, phosphorylated α-synuclein (p-syn) accumulation in skin biopsies in 19 PD patients who received curcumin supplementation for 12 months and 14 PD patients to treated with curcumin. The patients underwent autonomic (COMPASS-31), motor (MDS-UPDRS and H&Y) and nonmotor (NMSS) questionnaires and skin biopsies to evaluate clinical involvement and p-syn load in skin nerves at the beginning and the end of study. Curcumin and curcuminoid levels were assayed in plasma and CSF. Supplemented patients showed detectable CSF curcuminoid levels that were lower than those in plasma. They showed a decrease of COMPASS-31 and NMSS scores, and a slight p-syn load decrease versus untreated patients who displayed a worsening of these parameters despite increased levodopa doses. Multiple regression models showed a significant effect of curcumin supplementation in decreasing the worsening of the clinical parameters and p-syn load at after curcumin treatment. These data suggest that curcumin can cross the blood-brain barrier, that it is effective in ameliorating clinical parameters and that it shows a tendency to decrease skin p-syn accumulation in PD patients."
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DOH! It has to be a curcumin like the one in the study that uses phospholipids!
"The main results of our study indicate that curcumin: (1) is able to cross the blood-brain barrier in the form of its active metabolites when formulated in phospholipids; (2) is effective in ameliorating/stabilizing motor and nonmotor symptoms in PD; and (3) shows a tendency to decrease misfolded α-syn deposits in skin nerves as supported by the multiple regression model."
Most curcumin can't cross the BBB: Neuroprotection by curcumin: A review on brain delivery strategies sci-hub.ru/10.1016/j.ijphar...
The United States has an Alzheimer’s/dementia death rate which is the 2nd worst in the world (2nd only to Finland). Finland is 53.77 per 100,000 (age standardized), the US isn’t much better at 45.58. Now compare those numbers to 0.46 per 100,000 for India.
Have you tried golden milk turmeric tea? It is quite delicious and you will get coconut oil, ginger, cinnamon and lots of turmeric. I like the recipe called vegan Golden Milk Turmeric Latte, it uses oat milk, but you can substitute coconut or almond milk.
DOH! It has to be a curcumin like the one in the study that uses phospholipids!
"The main results of our study indicate that curcumin: (1) is able to cross the blood-brain barrier in the form of its active metabolites when formulated in phospholipids; (2) is effective in ameliorating/stabilizing motor and nonmotor symptoms in PD; and (3) shows a tendency to decrease misfolded α-syn deposits in skin nerves as supported by the multiple regression model."
Most curcumin can't cross the BBB: Neuroprotection by curcumin: A review on brain delivery strategies sci-hub.ru/10.1016/j.ijphar...
so the phytosome increases absorption because it acts like a fat sort of like liposomal supplements? Or, is it bc it somehow stays intact until deeper in the digestive system? Asking bc maybe putting the powder from a less expensive capsule and using it with an oil like MCT would work? (That’s how I take NMN although I think I’m stopping taking it)
According to the original paper the version of curcumin that crosses the BBB is the Meriva which is made with phospholipids.
According to this paper, Most curcumin can't cross the BBB: Neuroprotection by curcumin: A review on brain delivery strategies sci-hub.ru/10.1016/j.ijphar...
From what I can find, you need the Meriva version to get the curcumin to the brain.
Now for some good news! I found some cheap Meriva: $35 for 180 500 mg capsules. Take four a day, that is 2 grams a day, 45 day supply for $35. amazon.com/dp/B008YDH4HM?ps...
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