AB-1005

[Boscoejean]

By posting this I am not necessarily advocating this treatment just trying to find out more information on how it is made and how it is administered

Gene therapy AB-1005 found safe in Phase 1b Parkinson’s trial

parkinsonsnewstoday.com/new...

fiercebiotech.com/biotech/b....

AB-1005 was administered to the brain via one-time bilateral convection-enhanced delivery. The main goal was to evaluate the safety and potential clinical effect of the treatment.

"AB-1005 is an investigational gene therapy based on adeno-associated viral vector serotype 2 (AAV2) containing the human glial cell line-derived neurotrophic factor (GDNF) transgene, which allows for stable and continuous expression of GDNF in localized regions of the brain after direct neurosurgical injection with MRI ...

Convection enhanced delivery

ncbi.nlm.nih.gov/pmc/articl...

[garygjs]

Askbio use ClearPoint Neuro's intra-mri navigation and delivery system. (A confession: I own ClearPoint stock). ClearPoint's stuff is currently being used in several Parkinson's clinical trials.

There's a neat section on CED in this video:

youtube.com/watch?v=Xi1aGvL...(Not working as expected?)

[park_bear in reply to garygjs]

Very interesting. They are in no need of cash anytime soon, A reasonable entry point looking at the chart, and plenty of upside for sales.

d1io3yog0oux5.cloudfront.ne...

[park_bear]

askbio.com/askbio-announces...

"AB-1005 is also currently being investigated for the treatment of mild to moderate Parkinson’s disease with the enrollment of the Phase 1b study having now been completed"

clinicaltrials.gov/study/NC...