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NUV-1511 drug-drug conjugate (DDC) to enter the clinical stage: phase 1
"Dosing the first patient with NUV-1511 marks a significant milestone for our proprietary DDC platform, from which we are developing potent oncology-focused chimeric small molecules designed to selectively deliver anti-cancer therapeutics to cancer cells, while mitigating effects on healthy non-target
"Dosing the first patient with NUV-1511 marks a significant milestone for our proprietary DDC platform, from which we are developing potent oncology-focused chimeric small molecules designed to selectively deliver anti-cancer therapeutics to cancer cells, while mitigating effects on healthy non-target
Maxone73
in
Advanced Prostate Cancer
4 months ago
Coarsened Hepatic Echotexture
This finding is from the newest elastography. I thought I was doing everything right. KPA in 2022 was 10.5 F2-F.3, now it's 5.5 F0-F0-F1. I quit drinking alcohol in 2020, went on Mediterranean diet, and walk 1-3 miles per day. The only vice I have is baked goods, cookies, cake, and candy. 2022
This finding is from the newest elastography. I thought I was doing everything right. KPA in 2022 was 10.5 F2-F.3, now it's 5.5 F0-F0-F1. I quit drinking alcohol in 2020, went on Mediterranean diet, and walk 1-3 miles per day. The only vice I have is baked goods, cookies, cake, and candy. 2022
Evelyn22
in
British Liver Trust
4 months ago
AS the Journey continues
Well, the Board did complete its investigation. Five doctors were reprimanded. The resident on duty the night of the loss is no longer allowed to practice. The ICU doctor is no longer an ICU doctor but is still practicing—three more doctors whose disciplinary hearing was held behind closed doors three
Well, the Board did complete its investigation. Five doctors were reprimanded. The resident on duty the night of the loss is no longer allowed to practice. The ICU doctor is no longer an ICU doctor but is still practicing—three more doctors whose disciplinary hearing was held behind closed doors three
ceward204
in
British Liver Trust
4 months ago
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Synacthen Test
Hi, I received a letter from my Rheumatologist saying that my cortisol levels are normal following the Synacthen test 2 weeks ago. It says it is now safe to stop taking steroids. My question is, as i have been on steroids for over 5 years should i just stop or continue reducing. I am now taking 2.5mg
Hi, I received a letter from my Rheumatologist saying that my cortisol levels are normal following the Synacthen test 2 weeks ago. It says it is now safe to stop taking steroids. My question is, as i have been on steroids for over 5 years should i just stop or continue reducing. I am now taking 2.5mg
studiomaster
in
PMRGCAuk
4 months ago
Fiancé is in desperate need of a kidney
hi, My fiancé was born with a hereditary kidney disease. He’s been on dialysis for 3 years and is in dire need of a kidney. He’s been so positive and happy during this time , he even started a business this year all while being on dialysis. It’s been very inspiring to watch! I want to spread the
hi, My fiancé was born with a hereditary kidney disease. He’s been on dialysis for 3 years and is in dire need of a kidney. He’s been so positive and happy during this time , he even started a business this year all while being on dialysis. It’s been very inspiring to watch! I want to spread the
Nickywesley
in
Kidney Dialysis
4 months ago
Radiation after Docetaxel
My dad finished chemo Docetaxel in November 2023. In December his PSA was .61. In February it jumped to 2.3. He went for a PET scan. He went back to the doctor today his PSA jumped to 6. The scan showed that many of the metastasis in his bones shrunk are almost gone. There is one spot in his back that
My dad finished chemo Docetaxel in November 2023. In December his PSA was .61. In February it jumped to 2.3. He went for a PET scan. He went back to the doctor today his PSA jumped to 6. The scan showed that many of the metastasis in his bones shrunk are almost gone. There is one spot in his back that
Jshaw916
in
Advanced Prostate Cancer
4 months ago
We understand....
In my initial bio, I related to you that I had PBC for some 20 years before receiving a life saving liver transplant almost 19 years ago. In about 25% of those with liver transplants the PBC returns. We have to remember that our body still has the tendency to 'attack' it's own bile ducts and bile duct
In my initial bio, I related to you that I had PBC for some 20 years before receiving a life saving liver transplant almost 19 years ago. In about 25% of those with liver transplants the PBC returns. We have to remember that our body still has the tendency to 'attack' it's own bile ducts and bile duct
DonnaBoll
Administrator
in
PBC Foundation
4 months ago
AbbVie’s Produodopa approved by SMC to treat Parkinson’s disease patients in Scotland
AbbVie’s Produodopa (foslevodopa-foscarbidopa) has been accepted by the Scottish Medicines Consortium (SMC) for use within NHS Scotland to treat advanced levodopa-responsive Parkinson’s disease (PD). PD patients with severe motor fluctuations and hyperkinesia or dyskinesia when previous available combinations
AbbVie’s Produodopa (foslevodopa-foscarbidopa) has been accepted by the Scottish Medicines Consortium (SMC) for use within NHS Scotland to treat advanced levodopa-responsive Parkinson’s disease (PD). PD patients with severe motor fluctuations and hyperkinesia or dyskinesia when previous available combinations
Farooqji
in
Cure Parkinson's
4 months ago
Wednesday's 'Word'
[u][i]
NAFLD -
[/i][/u] Non alcoholic fatty liver disease. This is very common, characterized by deposits of fat in the liver cells. When these deposits cause inflammation and fat cells build up, it is known as [u][i]
NASH
[/i][/u] or non alcoholic steatohepatitis. It is often very common
[u][i]
NAFLD -
[/i][/u] Non alcoholic fatty liver disease. This is very common, characterized by deposits of fat in the liver cells. When these deposits cause inflammation and fat cells build up, it is known as [u][i]
NASH
[/i][/u] or non alcoholic steatohepatitis. It is often very common
DonnaBoll
Administrator
in
PBC Foundation
4 months ago
Ribonucleic Acid (RNA) and its Role in Parkinson’s Disease (PD) and Levodopa-induced Dyskinesias
https://www.apdaparkinson.org/article/rna-research-krithy-irmady/
https://www.apdaparkinson.org/article/rna-research-krithy-irmady/
Farooqji
in
Cure Parkinson's
4 months ago
PSA REACHES 5,125 !!
Diagnosed seven years ago with metastatic prostate cancer (PSA 1,666). Got down to 0.9 with hormone (eligard) shots. PSA increased, even with eligard. Recently completed my fourth of five Pluvicto infusion treatments (last due in one week). Currently, my PSA is at 5,125. Looking for similar
Diagnosed seven years ago with metastatic prostate cancer (PSA 1,666). Got down to 0.9 with hormone (eligard) shots. PSA increased, even with eligard. Recently completed my fourth of five Pluvicto infusion treatments (last due in one week). Currently, my PSA is at 5,125. Looking for similar
fsiefert
in
Advanced Prostate Cancer
4 months ago
Liver hemangiona
hi, I’ve just been told I have a small lover hemangiona. My mum passed away in September and her post mortem revealed advanced cancer of the gall bladder, bile ducts and liver lessions. I am told there is nothing to worry about but I have all the same symptoms my mum use to get, jaundiced eyes, swelling
hi, I’ve just been told I have a small lover hemangiona. My mum passed away in September and her post mortem revealed advanced cancer of the gall bladder, bile ducts and liver lessions. I am told there is nothing to worry about but I have all the same symptoms my mum use to get, jaundiced eyes, swelling
helnetball
in
British Liver Trust
4 months ago
Chemo progress
PSA 139 @ DX1-2024 started Orgovyx and Nubeqa dropped PSA to 62.93. Started Chemo 1st infusion..PSA 23.3 2nd infusion..PSA 11.26 3rd infusion.. PSA 7.45 Just got my labs back for the 3rd infusion. Just feel disappointed as I was hoping for a larger drop and seemed to have stalled out. Does it look
PSA 139 @ DX1-2024 started Orgovyx and Nubeqa dropped PSA to 62.93. Started Chemo 1st infusion..PSA 23.3 2nd infusion..PSA 11.26 3rd infusion.. PSA 7.45 Just got my labs back for the 3rd infusion. Just feel disappointed as I was hoping for a larger drop and seemed to have stalled out. Does it look
APK3
in
Advanced Prostate Cancer
4 months ago
Medication Change mid-Induction
Hello, I have renal limited vasculitis and am wondering if anyone has experience with a switch from Rituximab to Cyclophosphamide after 3 months of initial induction therapy? My first treatment that started almost 3 months ago was Rituximab with Prednisone. At first things were going well with eGFR
Hello, I have renal limited vasculitis and am wondering if anyone has experience with a switch from Rituximab to Cyclophosphamide after 3 months of initial induction therapy? My first treatment that started almost 3 months ago was Rituximab with Prednisone. At first things were going well with eGFR
Support_helps
in
Vasculitis UK
5 days ago
Effects of dietary intervention on human diseases: molecular mechanisms and therapeutic potential
Several neurodegenerative diseases (NDs), such as epilepsy, Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), and amyotrophic lateral sclerosis (ALS), which feature chronic progressive damage to the nervous system, have been proven to be tightly connected with nutrient availability
Several neurodegenerative diseases (NDs), such as epilepsy, Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), and amyotrophic lateral sclerosis (ALS), which feature chronic progressive damage to the nervous system, have been proven to be tightly connected with nutrient availability
Farooqji
in
Cure Parkinson's
4 months ago
Glioblastoma and Parkinson's; hereditary?
My mom was diagnosed with gliblastoma (brain cancer) in 2000. I was diagnosed with PD in 2015, If I understand it correctly, the folloing article indicates both conditions apparently can involve the same set of genes. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468383/ I am wondering if I might
My mom was diagnosed with gliblastoma (brain cancer) in 2000. I was diagnosed with PD in 2015, If I understand it correctly, the folloing article indicates both conditions apparently can involve the same set of genes. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468383/ I am wondering if I might
Jmellano
in
Cure Parkinson's
4 months ago
please help
My fiancé suffered a major stroke two weeks ago a day after being diagnosed with atrial fibrillation which caused two blood clots. He was in Addenbrooke’s for six days where the doctor told me if he survived this as it’s likely he could have another stroke that he would end up in a care home. I’m absolutely
My fiancé suffered a major stroke two weeks ago a day after being diagnosed with atrial fibrillation which caused two blood clots. He was in Addenbrooke’s for six days where the doctor told me if he survived this as it’s likely he could have another stroke that he would end up in a care home. I’m absolutely
Amity1
in
Headway
4 months ago
Selegiline - Noticeably improved symptoms
My new neurologist started me on Selegiline 10 mg/day. In two weeks I reduced my Sinemet from two pills per day to one. My tremor is much calmer and I feel more clear. So far no negative side effects and I take the first 5 mg on an empty stomach.
My new neurologist started me on Selegiline 10 mg/day. In two weeks I reduced my Sinemet from two pills per day to one. My tremor is much calmer and I feel more clear. So far no negative side effects and I take the first 5 mg on an empty stomach.
Armyman
in
Cure Parkinson's
4 months ago
Fibroscan Result - False?
Good Morning Everyone, I have been diagnosed with early cirrhosis last summer (July 2023) and have a Child Pugh A and a meld of 9. I have done two Elastology ultrasounds - first in July was 11.8 kpa and the second Nov 1st was 9.0 kpa. My liver enzymes are all in line and came back in line within
Good Morning Everyone, I have been diagnosed with early cirrhosis last summer (July 2023) and have a Child Pugh A and a meld of 9. I have done two Elastology ultrasounds - first in July was 11.8 kpa and the second Nov 1st was 9.0 kpa. My liver enzymes are all in line and came back in line within
Confused2024
in
British Liver Trust
4 months ago
Taste alteration
Hi, Has anyone experienced loss of taste after transplant? My partner says everything tastes absolutely horrendous. Will this come back?!
Hi, Has anyone experienced loss of taste after transplant? My partner says everything tastes absolutely horrendous. Will this come back?!
Gemmax
in
British Liver Trust
4 months ago
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