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Enzalutamide
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Resetting the Bar of Castration Resistance - Understanding Androgen Dynamics in Therapy Resistance and Treatment Choice in PCa
Patients were then re-treated with
enzalutamide
and 15 of them demonstrated 50% PSA reduction, suggesting re-sensitization to
enzalutamide
.
Patients were then re-treated with
enzalutamide
and 15 of them demonstrated 50% PSA reduction, suggesting re-sensitization to
enzalutamide
.
pjoshea13
in
Advanced Prostate Cancer
4 years ago
PSA back on the rise - or hitting Nadir?
Enzalutamide
, instead of Bicalutamide? My last scan (almost a year ago) showed seminal vesicle involvement, but no spread, so is salvage treatment impossible, even at this stage? I've also had genetic testing to see if I might have mutant BRCA 1/2 genes but still awaiting results due to Covid.
Enzalutamide
, instead of Bicalutamide? My last scan (almost a year ago) showed seminal vesicle involvement, but no spread, so is salvage treatment impossible, even at this stage? I've also had genetic testing to see if I might have mutant BRCA 1/2 genes but still awaiting results due to Covid.
CrocodileShoes
in
Advanced Prostate Cancer
4 years ago
Hang in there -- its happening
https://www.eurekalert.org/pub_releases/2020-09/iocr-e2b091820.php The innovative drug was more effective than the modern hormone treatments abiraterone and
enzalutamide
at slowing down the growth and spread of prostate cancer in patients with advanced disease.
https://www.eurekalert.org/pub_releases/2020-09/iocr-e2b091820.php The innovative drug was more effective than the modern hormone treatments abiraterone and
enzalutamide
at slowing down the growth and spread of prostate cancer in patients with advanced disease.
George71
in
Advanced Prostate Cancer
4 years ago
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Abiraterone [Zytiga] or Enzalutamide [Xtandi]?
The overall risk of cardiac disorders was higher with abiraterone versus
enzalutamide
; whereas
enzalutamide
was associated with a higher risk of hypertension.
The overall risk of cardiac disorders was higher with abiraterone versus
enzalutamide
; whereas
enzalutamide
was associated with a higher risk of hypertension.
pjoshea13
in
Advanced Prostate Cancer
4 years ago
Update on ARV-110 for anyone looking for a trial with a new drug approach - first in class - fast tracked May 2019
"In a patient-derived xenograft (PDX) model derived from a patient not treated with, but insensitive to
enzalutamide
, orally delivered ARV-110 significantly inhibited the growth of
enzalutamide
-insensitive tumors (tumor growth inhibition: 100%)."
"In a patient-derived xenograft (PDX) model derived from a patient not treated with, but insensitive to
enzalutamide
, orally delivered ARV-110 significantly inhibited the growth of
enzalutamide
-insensitive tumors (tumor growth inhibition: 100%)."
George71
in
Advanced Prostate Cancer
4 years ago
6-month Update: PSA down / Testosterone up
He wasnt fit for chemo and there is no Abiraterone or
Enzalutamide
in Venezuela, but he had a good response to ADT, and his last PSA came to 0,62 from 36 before treatment in march (but as high as 126 last december). He feels very good now, and gain some weight.
He wasnt fit for chemo and there is no Abiraterone or
Enzalutamide
in Venezuela, but he had a good response to ADT, and his last PSA came to 0,62 from 36 before treatment in march (but as high as 126 last december). He feels very good now, and gain some weight.
olloreda
in
Advanced Prostate Cancer
4 years ago
A high Neutrophil-to-Lymphocyte Ratio [NLR] is a poor prognostic factor for CRPC patients on Abiraterone [Abi] or Enzalutamide [Enz].
New study below [1]. I posted a review of the NLR-PCa literature 4 years ago: https://healthunlocked.com/advanced-prostate-cancer/posts/134756331/inflammation.-1-neutrophil-to-lymphocyte-ratio-nlr There have been similar studies since then. In the latest, from Japan: "A higher NLR was associated with
New study below [1]. I posted a review of the NLR-PCa literature 4 years ago: https://healthunlocked.com/advanced-prostate-cancer/posts/134756331/inflammation.-1-neutrophil-to-lymphocyte-ratio-nlr There have been similar studies since then. In the latest, from Japan: "A higher NLR was associated with
pjoshea13
in
Advanced Prostate Cancer
4 years ago
Free vs Total Testosterone? - Redux.
PSA response rates were 0% for abiraterone and
enzalutamide
in patients with the AR-V7 splice variant, which directly translated into shorter progression-free survival times (34).
PSA response rates were 0% for abiraterone and
enzalutamide
in patients with the AR-V7 splice variant, which directly translated into shorter progression-free survival times (34).
pjoshea13
in
Advanced Prostate Cancer
4 years ago
Zoladex and Enzalutamide?
The question basically is is zoladex and
enzalutamide
usually a good combination statistically and do you think his oncologist is being unreasonable in refusing to put him on zometa? Thanks again in advance!
The question basically is is zoladex and
enzalutamide
usually a good combination statistically and do you think his oncologist is being unreasonable in refusing to put him on zometa? Thanks again in advance!
Hillwalker87
in
Advanced Prostate Cancer
4 years ago
Starting Xtandi after PSA increase, what to expect?
Das has been advised to start
Xtandi
(
Enzalutamide
) 40mg - 4 pills a day. (2 each after breakfast and dinner). MO apparently believes Xtandi is better than Zytiga for a few reasons.
Das has been advised to start
Xtandi
(
Enzalutamide
) 40mg - 4 pills a day. (2 each after breakfast and dinner). MO apparently believes Xtandi is better than Zytiga for a few reasons.
Cheerr
in
Advanced Prostate Cancer
4 years ago
Low price Xtandi(Enzalutamide)
Today,I came across a news that generic version of
enzalutamide
has been launched in India by Zydus Cadila in the name of OBNYX 40 that costs around Rs. 25000 for a supply of 28 days,i.e, $340 approx. If any one is in need of the medicine please try to get it from India .
Today,I came across a news that generic version of
enzalutamide
has been launched in India by Zydus Cadila in the name of OBNYX 40 that costs around Rs. 25000 for a supply of 28 days,i.e, $340 approx. If any one is in need of the medicine please try to get it from India .
Vsahay
in
Advanced Prostate Cancer
4 years ago
Abiraterone vs Enzalutamide + Radiation
The literature also indicates that the sequence abiraterone-->
enzalutamide
is more favourable then
enzalutamide
-->abiraterone, but these are in settings where failure has occurred in the first hormone therapy. Your comments, are appreciated. Cheers, Phil
The literature also indicates that the sequence abiraterone-->
enzalutamide
is more favourable then
enzalutamide
-->abiraterone, but these are in settings where failure has occurred in the first hormone therapy. Your comments, are appreciated. Cheers, Phil
PhilipSZacarias
in
Advanced Prostate Cancer
4 years ago
BAT
More recent trials showed a further increase in overall survival when
enzalutamide
or abiraterone are associated with androgen deprivation therapy in hormone-sensitive disease.
More recent trials showed a further increase in overall survival when
enzalutamide
or abiraterone are associated with androgen deprivation therapy in hormone-sensitive disease.
podsart
in
Advanced Prostate Cancer
4 years ago
Research Study with Niaparib in combination with Abiraterone Acetate and Prednisone
The VA offered this or just
enzalutamide
. Any thoughts
The VA offered this or just
enzalutamide
. Any thoughts
DER326
in
Advanced Prostate Cancer
4 years ago
Adverse Events Related to Abiraterone and Enzalutamide Treatment
Clinicians should consider these data when treating cancer patients with abiraterone and
enzalutamide
.
Clinicians should consider these data when treating cancer patients with abiraterone and
enzalutamide
.
Balsam01
in
Advanced Prostate Cancer
4 years ago
[EAU-2020] Enzyme inhibition for overcoming CRPC.
In a second experiment performed in the same mouse model, animals were treated with vehicle,
enzalutamide
, 1 of the STS inhibitors, or
enzalutamide
plus the STS inhibitor.
In a second experiment performed in the same mouse model, animals were treated with vehicle,
enzalutamide
, 1 of the STS inhibitors, or
enzalutamide
plus the STS inhibitor.
pjoshea13
in
Advanced Prostate Cancer
4 years ago
Rucaparib in Metastatic Castration-Resistant Prostate Cancer With BRCA1/2 Alteration
All patients had metastatic CRPC and had been previously treated with both a taxane-containing regimen and a novel hormone such as abiraterone or
enzalutamide
. All patients had progressive disease at the time of trial entry and all patients had a pathogenic alteration in BRCA1 or BRCA2.
All patients had metastatic CRPC and had been previously treated with both a taxane-containing regimen and a novel hormone such as abiraterone or
enzalutamide
. All patients had progressive disease at the time of trial entry and all patients had a pathogenic alteration in BRCA1 or BRCA2.
Balsam01
in
Advanced Prostate Cancer
4 years ago
Adding carboplatin to chemotherapy for mCRPC in post-second generation hormone therapy setting: Impact on response and survival
New study below. [1] "We retrospectively identified 150 mCRPC patients with disease progression on
enzalutamide
or abiraterone. Of these 150 patients, 92 patients were chemo-naïve while 58 patients had previously received docetaxel chemotherapy before being started on second HT.
New study below. [1] "We retrospectively identified 150 mCRPC patients with disease progression on
enzalutamide
or abiraterone. Of these 150 patients, 92 patients were chemo-naïve while 58 patients had previously received docetaxel chemotherapy before being started on second HT.
pjoshea13
in
Advanced Prostate Cancer
4 years ago
23 months since chemo ended and still holding on Lupron/Enzalutamide
Adenocarcinoma is also responding to Lupron and
Enzalutamide
. (PSA <2). So my hybrid PC is now holding and I am enjoying whatever I can. This week we returned to a favorite spot to see the native Colorado columbine in bloom.
Adenocarcinoma is also responding to Lupron and
Enzalutamide
. (PSA <2). So my hybrid PC is now holding and I am enjoying whatever I can. This week we returned to a favorite spot to see the native Colorado columbine in bloom.
DenDoc
in
Advanced Prostate Cancer
4 years ago
When should ADT be started upon or after BCR in HSPC? An unanswered question.
Taken together with the results of the PROSPER trial (
enzalutamide
vs placebo) and the ARAMIS trial (darolutamide vs placebo), both of which also showed a survival advantage with the use of novel antiandrogen therapy in the nonmetastatic CRPC setting, there is now substantial evidence of significant
Taken together with the results of the PROSPER trial (
enzalutamide
vs placebo) and the ARAMIS trial (darolutamide vs placebo), both of which also showed a survival advantage with the use of novel antiandrogen therapy in the nonmetastatic CRPC setting, there is now substantial evidence of significant
MateoBeach
in
Advanced Prostate Cancer
4 years ago
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