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Enzalutamide
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EMBARK trial results already available?
EMBARK is a randomized Phase 3 study of
enzalutamide
plus leuprolide,
enzalutamide
monotherapy, and leuprolide alone in men with high-risk non-metastatic HSPC.
EMBARK is a randomized Phase 3 study of
enzalutamide
plus leuprolide,
enzalutamide
monotherapy, and leuprolide alone in men with high-risk non-metastatic HSPC.
GP24
in
Advanced Prostate Cancer
4 years ago
Neuroendocrine cells.
GnRH agonists and antagonists), inhibiting intratumoral androgen synthesis (i.e. abiraterone acetate) or competitive inhibition of AR itself (i.e.
enzalutamide
). This treatment, although initially effective, eventually fails after the tumor cells develop various mechanisms of resistance.
GnRH agonists and antagonists), inhibiting intratumoral androgen synthesis (i.e. abiraterone acetate) or competitive inhibition of AR itself (i.e.
enzalutamide
). This treatment, although initially effective, eventually fails after the tumor cells develop various mechanisms of resistance.
pjoshea13
in
Advanced Prostate Cancer
3 years ago
BAT: transformer trial
(Testosterone Revival Abolishes Negative Symptoms, Fosters Objective Response and Modulates
Enzalutamide
Resistance (Transformer) – what violence we do to language in science!) In this one they took about 200 asymptomatic patients who had progressed on abiraterone and had not taken
enzalutamide
.
(Testosterone Revival Abolishes Negative Symptoms, Fosters Objective Response and Modulates
Enzalutamide
Resistance (Transformer) – what violence we do to language in science!) In this one they took about 200 asymptomatic patients who had progressed on abiraterone and had not taken
enzalutamide
.
kaptank
in
Advanced Prostate Cancer
3 years ago
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Advice and Opinions would be great.
*
Enzalutamide
(Xtandi) * Ketoconazole * High dose Testosterone to shock the PCa cells.
*
Enzalutamide
(Xtandi) * Ketoconazole * High dose Testosterone to shock the PCa cells.
taylor123
in
Advanced Prostate Cancer
3 years ago
Update to Can't treat what we can't see
Following is from the After Visit Summary: We discussed a recommendation for
enzalutamide
at this point - while it may have a lower response rate compared to docetaxel, especially after progression on abiraterone therapy, the toxicity of docetaxel is significantly greater, especially in the context
Following is from the After Visit Summary: We discussed a recommendation for
enzalutamide
at this point - while it may have a lower response rate compared to docetaxel, especially after progression on abiraterone therapy, the toxicity of docetaxel is significantly greater, especially in the context
SF22
in
Advanced Prostate Cancer
3 years ago
New York Times article on the recent Lutetium-177–PSMA-617 study [VISION] + NEJM paper
., abiraterone and
enzalutamide
).
., abiraterone and
enzalutamide
).
pjoshea13
in
Advanced Prostate Cancer
3 years ago
To treat or not to treat: is it acceptable to avoid active therapies in advanced prostate cancer today?
Furthermore, two more recent phase III RCTs have shown that adding
enzalutamide
[9] or apalutamide [14] to ADT improves OS in comparison with ADT alone.
Furthermore, two more recent phase III RCTs have shown that adding
enzalutamide
[9] or apalutamide [14] to ADT improves OS in comparison with ADT alone.
pjoshea13
in
Advanced Prostate Cancer
3 years ago
Title :Enzalutamide and Niclosamide in Treating Patients With Recurrent or Metastatic Castration-Resistant Prostate Cancer
With all the interest in my last post I thought some might be interested in this: https://www.cureitt.com/trialdetails?nctid=NCT03123978 Maybe someone out there could explain the difference between niclosamide and Fenbendazole, they are both used for deworming dogs.
With all the interest in my last post I thought some might be interested in this: https://www.cureitt.com/trialdetails?nctid=NCT03123978 Maybe someone out there could explain the difference between niclosamide and Fenbendazole, they are both used for deworming dogs.
Magnus1964
in
Advanced Prostate Cancer
4 years ago
I vitro evidence for effectiveness of Simvastatin Metformin combination against Enzalutamide resistant CRPC
The second generation androgen receptor (AR) antagonist
enzalutamide
(ENZU) exhibits survival advantage in CRPC patients, however ∼30% of patients develop resistance overtime activating AR in these tumors.
The second generation androgen receptor (AR) antagonist
enzalutamide
(ENZU) exhibits survival advantage in CRPC patients, however ∼30% of patients develop resistance overtime activating AR in these tumors.
Graham49
in
Advanced Prostate Cancer
4 years ago
Sipuleucel-T boosts survival versus abiraterone or enzalutamide alone in real-world mCRPC analysis
The median OS was improved by 14.5 months with sipuleucel-T https://www.urologytimes.com/view/sipuleucel-t-boosts-survival-versus-abiraterone-or-
enzalutamide
-alone-in-real-world-mcrpc-analysis
The median OS was improved by 14.5 months with sipuleucel-T https://www.urologytimes.com/view/sipuleucel-t-boosts-survival-versus-abiraterone-or-
enzalutamide
-alone-in-real-world-mcrpc-analysis
George71
in
Advanced Prostate Cancer
4 years ago
Enzalutamide and headaches
I've recently started on
enzalutamide
. I am experiencing headaches since I started taking this drug. Some evenings I'm ok, others I get the headache. I spoke to the hospital and they told me, come back to us if this persists. They think it might be my body getting used to enza.
I've recently started on
enzalutamide
. I am experiencing headaches since I started taking this drug. Some evenings I'm ok, others I get the headache. I spoke to the hospital and they told me, come back to us if this persists. They think it might be my body getting used to enza.
londoncyclist48
in
Advanced Prostate Cancer
4 years ago
Starting enzalutamide
MO recommends adding
enzalutamide
to current ADT regimen since PSA has gradually risen to 4.4 from 2,9 in 3 months. Original idea was for darolutamide but insurance disallowed. Passed on Zytinga with the prednisone due to afib and mild heart failure.
MO recommends adding
enzalutamide
to current ADT regimen since PSA has gradually risen to 4.4 from 2,9 in 3 months. Original idea was for darolutamide but insurance disallowed. Passed on Zytinga with the prednisone due to afib and mild heart failure.
33947
in
Advanced Prostate Cancer
4 years ago
Latest Axumin scan
If a no go with BAT will do
enzalutamide
and see where PSA goes, then SWITCH to Dexamethasone, then a Taxotere rechallenge Life with #stageivpca Fight on Brothers 💙 Mahalo Randy Btw, Kaiser PSA two weeks after my 9.2 was a 7.8🤔 from LabCorp
If a no go with BAT will do
enzalutamide
and see where PSA goes, then SWITCH to Dexamethasone, then a Taxotere rechallenge Life with #stageivpca Fight on Brothers 💙 Mahalo Randy Btw, Kaiser PSA two weeks after my 9.2 was a 7.8🤔 from LabCorp
dockam
in
Advanced Prostate Cancer
4 years ago
Zoladex not working
I am told it would probably be
Enzalutamide
. Can anyone tell me if it works and possible side effects? Almost 74 GS 9 out of gland 7 weeks radiation in 98.. Been on intermittent anti hormonal therapy for about 15 years..
I am told it would probably be
Enzalutamide
. Can anyone tell me if it works and possible side effects? Almost 74 GS 9 out of gland 7 weeks radiation in 98.. Been on intermittent anti hormonal therapy for about 15 years..
roncyn
in
Advanced Prostate Cancer
4 years ago
Resetting the Bar of Castration Resistance - Understanding Androgen Dynamics in Therapy Resistance and Treatment Choice in PCa
Patients were then re-treated with
enzalutamide
and 15 of them demonstrated 50% PSA reduction, suggesting re-sensitization to
enzalutamide
.
Patients were then re-treated with
enzalutamide
and 15 of them demonstrated 50% PSA reduction, suggesting re-sensitization to
enzalutamide
.
pjoshea13
in
Advanced Prostate Cancer
4 years ago
PSA back on the rise - or hitting Nadir?
Enzalutamide
, instead of Bicalutamide? My last scan (almost a year ago) showed seminal vesicle involvement, but no spread, so is salvage treatment impossible, even at this stage? I've also had genetic testing to see if I might have mutant BRCA 1/2 genes but still awaiting results due to Covid.
Enzalutamide
, instead of Bicalutamide? My last scan (almost a year ago) showed seminal vesicle involvement, but no spread, so is salvage treatment impossible, even at this stage? I've also had genetic testing to see if I might have mutant BRCA 1/2 genes but still awaiting results due to Covid.
CrocodileShoes
in
Advanced Prostate Cancer
4 years ago
Hang in there -- its happening
https://www.eurekalert.org/pub_releases/2020-09/iocr-e2b091820.php The innovative drug was more effective than the modern hormone treatments abiraterone and
enzalutamide
at slowing down the growth and spread of prostate cancer in patients with advanced disease.
https://www.eurekalert.org/pub_releases/2020-09/iocr-e2b091820.php The innovative drug was more effective than the modern hormone treatments abiraterone and
enzalutamide
at slowing down the growth and spread of prostate cancer in patients with advanced disease.
George71
in
Advanced Prostate Cancer
4 years ago
Abiraterone [Zytiga] or Enzalutamide [Xtandi]?
The overall risk of cardiac disorders was higher with abiraterone versus
enzalutamide
; whereas
enzalutamide
was associated with a higher risk of hypertension.
The overall risk of cardiac disorders was higher with abiraterone versus
enzalutamide
; whereas
enzalutamide
was associated with a higher risk of hypertension.
pjoshea13
in
Advanced Prostate Cancer
4 years ago
Update on ARV-110 for anyone looking for a trial with a new drug approach - first in class - fast tracked May 2019
"In a patient-derived xenograft (PDX) model derived from a patient not treated with, but insensitive to
enzalutamide
, orally delivered ARV-110 significantly inhibited the growth of
enzalutamide
-insensitive tumors (tumor growth inhibition: 100%)."
"In a patient-derived xenograft (PDX) model derived from a patient not treated with, but insensitive to
enzalutamide
, orally delivered ARV-110 significantly inhibited the growth of
enzalutamide
-insensitive tumors (tumor growth inhibition: 100%)."
George71
in
Advanced Prostate Cancer
4 years ago
6-month Update: PSA down / Testosterone up
He wasnt fit for chemo and there is no Abiraterone or
Enzalutamide
in Venezuela, but he had a good response to ADT, and his last PSA came to 0,62 from 36 before treatment in march (but as high as 126 last december). He feels very good now, and gain some weight.
He wasnt fit for chemo and there is no Abiraterone or
Enzalutamide
in Venezuela, but he had a good response to ADT, and his last PSA came to 0,62 from 36 before treatment in march (but as high as 126 last december). He feels very good now, and gain some weight.
olloreda
in
Advanced Prostate Cancer
4 years ago
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