Experiences with

Enzalutamide

Kriti Mittal MD, MS, FACP June 23, 2021 https://www.medpagetoday.com/reading-room/asco/non-prostate-genitourinary-cancer/93235 This is an example of doctors using the newly approved 18F-Sodium Fluoride PET/CT to help tailor treatments based on individual patient responses, in this case, that of Enzalutamide

Bo says I am M1 CRPC (I am not really sure if this is really the case), and he suggested either Abiraterone, Enzalutamide, or Radium-233. Will also see Ohio State Dr. Min Yin July 21 to see what he thinks. Any thoughts? Thanks

Just when I was about to start a promising new trial using 225Ac-J591, along with Keytruda + Enzalutamide - “While early clinical results from actinium-225-based radiopharmaceuticals have been promising, the extreme global shortage of actinium-225 has slowed research and development activities and made

I am on monotherapy enzalutamide and have been for some time. My T is 600+. Enza prohibits the uptake of androgens everywhere in the body, not just the tumor cells, so no T in muscles and elsewhere while it circulates in serum. He noted I had not had a bone density test in several years.

[u]patients with CAR > 0.5 has significantly shorter CSS than those with CAR ≤ 0.5 in abiraterone (median of 23 vs 49 months ...) and enzalutamide (median of 23 vs 41 months[/u] ...)" Quite a big difference. What does "prognostic" mean?

Will reevaluate after 6th chemo, but likely course is adding abiraterone or enzalutamide, and radiation to prostate. We are both still working and live by our calendars. We can relocate to Rochester, MN and work remotely if necessary but it would be great to plan for possible scenarios.

) and enzalutamide (ENZ) are commonly prescribed for metastatic castration-resistant prostate cancer (mCRPC).

The clinical relevance of intratumoural androgens in promoting prostate tumour growth is clearly confirmed by the efficacy of potent ligand synthesis and AR inhibitors such as abiraterone and enzalutamide.

Has anyone had a good response with enzalutamide (Xtandi) after abiraterone? *My father has not been on chemo yet.

Signaling Inhibitor) ******************************************************** [i]For the purposes of this review, we will focus our discussion on the newer, more effective ARSIs: specifically, the CYP17 inhibitor abiraterone and the 2nd generation AR ligand-binding domain (LBD) antagonists (antiandrogens) enzalutamide

New activity is likely the old adenocarcinoma which has found a "work around" after 10 plus years of ADT and Enzalutamide not working to block AR receptors. So we made a decision to start on Abiraterone/prednisone now while continuing on Lupron. So far tolerating the new drugs and labs are okay.

New Paper: “Hexose-6-phosphate dehydrogenase blockade reverses prostate cancer drug resistance in xenograft models by glucocorticoid inactivation” https://stm.sciencemag.org/content/13/595/eabe8226

The open-label phase 3 VISION trial (NCT03511664) included 831 patients (1179 initially screened) with progressive PSMA-positive mCRPC who received at least 1 novel androgen axis drug (eg, enzalutamide [Xtandi] or abiraterone acetate [Zytiga]) and were previously treated with 1 to 2 taxane regimens.

I had my first infusion in Febuary 2021 after Enzalutamide (Xtandi) stopped working and PSA increased to 50. My first infusion reduced my PSA to 3.5. My second infusion on 8 April 2021 reduced my PSA to .6.

Enzalutamide appeared to have better OS compared with docetaxel in men with low-volume disease, but there was no difference in other comparisons.

We demonstrate an increased number of BRCA2 alterations post-enzalutamide highlighting importance of serial tumor sampling in CRPC.

demonstrated A. muciniphila to invoke a multiplicity of health benefits in their hosts and improve the efficacy of checkpoint inhibitor cancer immunotherapies" 2] 2018, Johns Hopkins: This study reported that that [u]oral[/u] androgen receptor axis-targeted therapies (ATT), including bicalutamide, enzalutamide

So, 7 months on enzalutamide has passed quickly and I get a phone call out of the blue from the Royal Marsden. "We want you to start targeted radiotherapy on your prostate. Please come in for us to arrange this." My PSA currently hovers around 0.18.

But, if he is put into the control group, he'd receive enzalutamide (another ADT drug). 2. Olaparib (Lynparza) - I'm not super convinced of the efficacy of this treatment course.

By the way, one of the important findings from the transformer study is that after the use of testosterone, you can re-sensitize to things like enzalutamide, and you can come back with the enzalutamide and get a very high response rate. And that is a different subset analysis.