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Enzalutamide
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ESMO 2024: phase 1/2 trial of oral masofaniten (EPI-7386) plus Enzalutamide compared to Enzalutamide alone in men with mCRPC
Pharmacokinetic analyses indicated that
enzalutamide
did not affect Masofaniten exposure, allowing for full dosing of
enzalutamide
.
Pharmacokinetic analyses indicated that
enzalutamide
did not affect Masofaniten exposure, allowing for full dosing of
enzalutamide
.
Maxone73
in
Advanced Prostate Cancer
10 days ago
Enzalutamide
Are any others experiencing metallic tasting food while taking
enzalutamide
? I’ve noticed that for myself along with poor appetite with weight loss.
Are any others experiencing metallic tasting food while taking
enzalutamide
? I’ve noticed that for myself along with poor appetite with weight loss.
MooseJawg
in
Advanced Prostate Cancer
2 months ago
Xtandi reduces effect of tamsulosin plus dutaseride ?
Dad has been on BPH medicine since 2011 to control symptoms of prostate enlargement - It contains tamsulosin and dutaseride Recently he has also added xtandi -
enzalutamide
I read online on drug interaction sites that
enzalutamide
can reduce efficacy of tamsulosin.
Dad has been on BPH medicine since 2011 to control symptoms of prostate enlargement - It contains tamsulosin and dutaseride Recently he has also added xtandi -
enzalutamide
I read online on drug interaction sites that
enzalutamide
can reduce efficacy of tamsulosin.
Tinkudi
in
Advanced Prostate Cancer
17 hours ago
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in vitro/in vivo but interesting: another therapeutic path of Enzalutamide
"This study reveals a previously unrecognized function of
enzalutamide
and AR by regulating PEX10 and suggests a new strategy of
enzalutamide
application in prostate cancer treatment." Not applied to any trial yet but an important finding! https://www.nature.com/articles/s41419-024-06937-7
"This study reveals a previously unrecognized function of
enzalutamide
and AR by regulating PEX10 and suggests a new strategy of
enzalutamide
application in prostate cancer treatment." Not applied to any trial yet but an important finding! https://www.nature.com/articles/s41419-024-06937-7
Maxone73
in
Advanced Prostate Cancer
2 months ago
Enzalutamide
I was also taking 400mg
Enzalutamide
daily. I was experience serious daytime sleepiness and brain fog, so the oncologist stopped the
Enzalutamide
for 6 months. My weight continue to increase, so he said the
Enzalutamide
was not the cause and started it again.
I was also taking 400mg
Enzalutamide
daily. I was experience serious daytime sleepiness and brain fog, so the oncologist stopped the
Enzalutamide
for 6 months. My weight continue to increase, so he said the
Enzalutamide
was not the cause and started it again.
RLSHell
in
Restless Legs Syndrome
3 months ago
Retrospective cohort study comparing ARIs; darolutamide, enzalutamide, and apalutamide in 870 non metastatic CRPC patients
Results suggest darolutamide is associated with longer treatment duration and time to progression to mCRPC compared with
enzalutamide
and apalutamide in a routine care setting, while no differences in either outcome were found between
enzalutamide
and apalutamide.
Results suggest darolutamide is associated with longer treatment duration and time to progression to mCRPC compared with
enzalutamide
and apalutamide in a routine care setting, while no differences in either outcome were found between
enzalutamide
and apalutamide.
Graham49
in
Advanced Prostate Cancer
28 days ago
Restrospective Study of Apalutamide, Darolutamide and Enzalutamide in Patients with Nonmetastatic, Castrate Resistant Prostate Cancer
“Meaning These findings suggest that darolutamide has a better tolerability profile compared with
enzalutamide
and apalutamide, which may be associated with an effectiveness advantage in routine clinical practice in men with nmCRPC.”
“Meaning These findings suggest that darolutamide has a better tolerability profile compared with
enzalutamide
and apalutamide, which may be associated with an effectiveness advantage in routine clinical practice in men with nmCRPC.”
Survivor86
in
Advanced Prostate Cancer
27 days ago
Denmeade on identifying patients who may benefit from BAT
Additional clinical trials with BAT are open and actively accruing: STEP-UP (sequencing BAT and
Enzalutamide
) APEX (sequencing BAT + Difluoromethylornithine (DFMO) with
Enzalutamide
) BATRAD (BAT + 223 Radium) AcroBAT (oral testosterone) However, patients with AR alterations treated with BAT trend
Additional clinical trials with BAT are open and actively accruing: STEP-UP (sequencing BAT and
Enzalutamide
) APEX (sequencing BAT + Difluoromethylornithine (DFMO) with
Enzalutamide
) BATRAD (BAT + 223 Radium) AcroBAT (oral testosterone) However, patients with AR alterations treated with BAT trend
cigafred
in
Fight Prostate Cancer
4 months ago
Niclosamide and Enzalutamide in Treating Patients with Castration-Resistant, Metastatic Prostate Cancer
Niclosamide and
Enzalutamide
in Treating Patients with Castration-Resistant, Metastatic Prostate Cancer
Niclosamide and
Enzalutamide
in Treating Patients with Castration-Resistant, Metastatic Prostate Cancer
85745
in
Advanced Prostate Cancer
1 month ago
Enzalutamide Plus 5-Alpha Reductase Inhibitors for Castrate-Sensitive Prostate Cancer
Phase II trial exploring the combination of
enzalutamide
with five alpha-reductase inhibitors (ARIs) for castrate-sensitive prostate cancer.
Phase II trial exploring the combination of
enzalutamide
with five alpha-reductase inhibitors (ARIs) for castrate-sensitive prostate cancer.
God_Loves_Me
in
Advanced Prostate Cancer
3 months ago
Enzalutamide before Abiraterone
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2822420 A recent study concludes that
Enzalutamide
is slightly more beneficial if used before Abiraterone. This is contrary to other studies which some of you have posted recently.
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2822420 A recent study concludes that
Enzalutamide
is slightly more beneficial if used before Abiraterone. This is contrary to other studies which some of you have posted recently.
Ausi
in
Advanced Prostate Cancer
1 month ago
Anyone treated with enzalutamide +cabazitaxel?
MO suggested cabazitaxel (1st choice) or
enzalutamide
(discouraged because cancer is aggressive). Any data/experience that combined
enzalutamide
and cabazitaxel would be better?
MO suggested cabazitaxel (1st choice) or
enzalutamide
(discouraged because cancer is aggressive). Any data/experience that combined
enzalutamide
and cabazitaxel would be better?
BeLikeWater
in
Advanced Prostate Cancer
3 months ago
Radium 223 + Enzalutamide increase rPFS in castration resistante prostate cancer
As Tall Allen posted, here is the link to the numbers: https://www.onclive.com/view/addition-of-radium-223-to-
enzalutamide
-significantly-improves-rpfs-and-os-in-mcrpc
As Tall Allen posted, here is the link to the numbers: https://www.onclive.com/view/addition-of-radium-223-to-
enzalutamide
-significantly-improves-rpfs-and-os-in-mcrpc
Maxone73
in
Advanced Prostate Cancer
12 days ago
Radionuclide-Containing Combo Slows Metastatic Prostate Cancer, Improves Survival, MedPage Today September 15, 2024
Grade 3-5 DRAEs occurred in 28% of patients randomized to Ra-223 versus 19% of those who received single-agent
enzalutamide
. Fatal AEs occurred in 3% of the combination arm and 2% of the
enzalutamide
arm.
Grade 3-5 DRAEs occurred in 28% of patients randomized to Ra-223 versus 19% of those who received single-agent
enzalutamide
. Fatal AEs occurred in 3% of the combination arm and 2% of the
enzalutamide
arm.
cujoe
in
Fight Prostate Cancer
10 days ago
This study indicates not enough metastatic PCa patients are having Next Generation Sequence testing (NGS)
of
enzalutamide
or abiraterone.
of
enzalutamide
or abiraterone.
Graham49
in
Advanced Prostate Cancer
2 months ago
EMBARK Trial: Combination-therapy is better.
Lupron
monotherapy had the greatest risk of developing metastasis after 5 years (a 28.6 %), compared to a 20.0% risk for
monotherapy. The
combination of
+ Lupron had the lowest risk (12.7%). p < 0.001 (N=1068).
Lupron
monotherapy had the greatest risk of developing metastasis after 5 years (a 28.6 %), compared to a 20.0% risk for
monotherapy. The
combination of
+ Lupron had the lowest risk (12.7%). p < 0.001 (N=1068).
janebob99
in
Prostate Cancer Network
5 months ago
Darolutamide (Nubeqa) Vs Enzalutamide ( Xtandi)
Are there any studies comparing efficacy and side effect profile of darolutamide Vs
enzalutamide
when given together with first generation ADT ? I read that darolutamide does not cross blood brain barrier so may have lesser side effects ?
Are there any studies comparing efficacy and side effect profile of darolutamide Vs
enzalutamide
when given together with first generation ADT ? I read that darolutamide does not cross blood brain barrier so may have lesser side effects ?
Tinkudi
in
Advanced Prostate Cancer
3 months ago
could be of interest for those on BAT
Extreme responses to immune checkpoint blockade following bipolar androgen therapy and
enzalutamide
in patients with metastatic castration resistant prostate cancer https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585736/
Extreme responses to immune checkpoint blockade following bipolar androgen therapy and
enzalutamide
in patients with metastatic castration resistant prostate cancer https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585736/
Maxone73
in
Advanced Prostate Cancer
4 months ago
New diagnosis... & Enzalutamide question
Blood tests taken last week before I was put on
Enzalutamide
- PSA had dropped to 0.88... I thought I'd misheard when she told me. I'm also experimenting with supplements. A friend with a difficult to treat cancer eventually refused chemo/radio/surgery.
Blood tests taken last week before I was put on
Enzalutamide
- PSA had dropped to 0.88... I thought I'd misheard when she told me. I'm also experimenting with supplements. A friend with a difficult to treat cancer eventually refused chemo/radio/surgery.
Broccoli24
in
Advanced Prostate Cancer
28 days ago
Can we try Enzalutamide when Abiraterone failed , Just before chemotherapy
So, can we take
Enzalutamide
for this period before chemotherapy , will it ease the pain and held up the progression ? Thanks all for your kind reply.
So, can we take
Enzalutamide
for this period before chemotherapy , will it ease the pain and held up the progression ? Thanks all for your kind reply.
jeetu_g27
in
Advanced Prostate Cancer
7 days ago
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