Enzalutamide

[RLSHell]

Hi

I take 30mg Targinact and 300mg Gabapentin for severe RLS

I'm also taking quarterly Prostap injections to prevent the spread of prostate cancer. I was also taking 400mg Enzalutamide daily. I was experience serious daytime sleepiness and brain fog, so the oncologist stopped the Enzalutamide for 6 months. My weight continue to increase, so he said the Enzalutamide was not the cause and started it again. Over the two/three weeks since I re-started my RL got steadily worse and I began to worry that the Targinact was Augmenting. Even though the Enzalutamide hadn't made things worse when I started on it 2.5 years ago, I wondered if it was the cause, so I stopped. Within a week my RLS was back under control. My questions are

Is Enzalutimide known to worsen RLS (I tried to search the HealthUnlocked site before asking this, but got thousands of Prostate Cancer results)?

Would taking a higher dose of Targinact or Gabapentin enable me to take Enzalutamide?

Has anyone experience this and did the oncologist find an alternative drug which doesn't make RLS worse?

Can Targinact go into Augmentation?

As always, the advice of community members is greatly appreciated

[SueJohnson]

It's not known to make RLS worse. If your RLS is under control with gabapentin and targinact and you take more, it is possible you can take it. Mine is under control with gabapentin and I know I am probably taking more than I need as I have forgotten a dose every once in a while without it affecting me and I can take the known triggers of melatonin and benadryl.

[ChrisColumbus]

There have been reports that RLS is a side effect of enzalutamide (Xtandi)

"patients treated with ENZ had a statistically significant higher risk of restless leg syndrome (RLS), anxiety, headache and insomnia vs control."

ascopubs.org/doi/10.1200/JC...

RLS is listed as an occasional side effect by Cancer Research UK:

cancerresearchuk.org/about-...

I had anti androgen therapy when I had prostate cancer, but (i) I don't recall which drug was used, and (ii) I was taking atorvastatin after a mini-stroke at the same time that was blamed for sending my RLS through the roof.

There are various different types of anti androgens including:

bicalutamide (Casodex)

cyproterone acetate (Cyprostat)

flutamide (Drogenil)

enzalutamide (Xtandi)

apalutamide (Erleada)

darolutamide (Nubeqa)

abiraterone (Zytiga)

But which of these might be suitable in your case, and which may or may not exacerbate RLS, I'm afraid that I don't know. And, never having taken it, I don't know whether taking a higher dose of gabapentin would help.

[SueJohnson in reply to ChrisColumbus]

Thank you. I hadn't found anything but will now add it to my list of drugs that may make RLS worse.