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Dutasteride and PSA dropping
I started taking dustasteride about 1 month ago because of high DHT and my PSA dropped from 10 to 5.5. I've read that you are supposed to double the PSA to get an "equivalent" non-dutasteride level of 11. Does anyone understand why we are supposed to double the PSA value when taking dutasteride?
I started taking dustasteride about 1 month ago because of high DHT and my PSA dropped from 10 to 5.5. I've read that you are supposed to double the PSA to get an "equivalent" non-dutasteride level of 11. Does anyone understand why we are supposed to double the PSA value when taking dutasteride?
janebob99
in
Prostate Cancer Network
9 months ago
PSA dropping and % free ratio rising - why?
OK, so as you can see from my Bio, I live in Australia and was due to start my HT this month. However, on Dec 5th, we decided to do another PSA test and surprisingly it had dropped from 8.1 in July to 4.9, so I thought maybe we should get another MRI to see what is going on. I had the MRI only a few
OK, so as you can see from my Bio, I live in Australia and was due to start my HT this month. However, on Dec 5th, we decided to do another PSA test and surprisingly it had dropped from 8.1 in July to 4.9, so I thought maybe we should get another MRI to see what is going on. I had the MRI only a few
Mike58
in
Prostate Cancer Network
9 months ago
Darolutamide failing after 2 years. Any success if I switch to Xandi or Zytiga or do I need to move to Pluvicto.
Dx 2018. PSA 16. Been on Orgovyx. Started Second line (Darolutamide) two years ago when PSA started to rise. PSA rose over the [u]last 5 months[/u] from 0.021 (August) to 0.48 I had a few bone mets and several lymph nodes when dx. Trying to find other treatments since I'm running out of Standard
Dx 2018. PSA 16. Been on Orgovyx. Started Second line (Darolutamide) two years ago when PSA started to rise. PSA rose over the [u]last 5 months[/u] from 0.021 (August) to 0.48 I had a few bone mets and several lymph nodes when dx. Trying to find other treatments since I'm running out of Standard
Longterm101
in
Advanced Prostate Cancer
9 months ago
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Overall Survival With [177]Lu-PSMA-617 vs Cabazitaxel in Metastatic Castration-Resistant Prostate Cancer
The Lancet Oncology TAKE-HOME MESSAGE TheraP was a phase II trial that compared the efficacy of radioligand therapy with 177Lu-PSMA-617 with that of cabazitaxel in patients with metastatic castration-resistant prostate cancer who had previously received docetaxel. After a median follow-up of 35.7 months
The Lancet Oncology TAKE-HOME MESSAGE TheraP was a phase II trial that compared the efficacy of radioligand therapy with 177Lu-PSMA-617 with that of cabazitaxel in patients with metastatic castration-resistant prostate cancer who had previously received docetaxel. After a median follow-up of 35.7 months
Magnus1964
in
Advanced Prostate Cancer
9 months ago
"Two Invitae CHEK2 variants of "unknown consequence""
Hello - My Hopkins MO says this genetics test indicates a weakness (CHEK2 is one of the 4 or 5 PCa related variants) he thinks this could have contributed to my premature, two year BCR after RP, so he will likely prescribe chemo sooner than later though PSA will be the prime indicator. Further he suggested
Hello - My Hopkins MO says this genetics test indicates a weakness (CHEK2 is one of the 4 or 5 PCa related variants) he thinks this could have contributed to my premature, two year BCR after RP, so he will likely prescribe chemo sooner than later though PSA will be the prime indicator. Further he suggested
jackwfrench
in
Advanced Prostate Cancer
9 months ago
Criteria for "my ADT has stopped working and we have to move to another"
Hello - So my third post ADT initiation (Lupron+Abi) PSA test is coming up and since it was <.1 six weeks ago, I asked how the criteria of “has stopped working” works -to my Hopkins MO and I got this - “We want to declare a therapy no longer effective when PSA is clearly going up. We look for 0.3
Hello - So my third post ADT initiation (Lupron+Abi) PSA test is coming up and since it was <.1 six weeks ago, I asked how the criteria of “has stopped working” works -to my Hopkins MO and I got this - “We want to declare a therapy no longer effective when PSA is clearly going up. We look for 0.3
jackwfrench
in
Advanced Prostate Cancer
9 months ago
Promising, especially for people with LBD mutation: NEJM Evidence publishes results from Phase I/IIa CYPIDES trial with ODM-208
"In phase I, 20 out of the total 47 patients had AR LBD mutation. In phase IIa, all 45 patients had AR LBD mutation. A decrease in PSA (prostate-specific antigen) levels of 50% or more occurred in 14/19 (73.7%) patients with AR LBD mutation and 2/23 (8.7%) AR-wild-type patients in phase I, and in 24/
"In phase I, 20 out of the total 47 patients had AR LBD mutation. In phase IIa, all 45 patients had AR LBD mutation. A decrease in PSA (prostate-specific antigen) levels of 50% or more occurred in 14/19 (73.7%) patients with AR LBD mutation and 2/23 (8.7%) AR-wild-type patients in phase I, and in 24/
Maxone73
in
Advanced Prostate Cancer
9 months ago
Prostate cancer
My prostate condition started around eight years ago when I had urinary track infection which also led to prostatitis. Ever since then, my PSA jumped from 2 to 7.8 during the last 5 years. I had two biopsies… first one, four years ago, they detected no positive cancer cells in my prostate. However
My prostate condition started around eight years ago when I had urinary track infection which also led to prostatitis. Ever since then, my PSA jumped from 2 to 7.8 during the last 5 years. I had two biopsies… first one, four years ago, they detected no positive cancer cells in my prostate. However
Yuncoinc7148
in
Fight Prostate Cancer
9 months ago
Lymparza not working
hi..my husband was initially diagnosed stage 4b in 2020. He did well on chemo, and lupron. He is also on xgeva. He then went on zytiga for about 7 months before it started failing. He did get accepted in the luteciun trial at Penn on control arm. He did very well on Xtandi but was ended this past Aug
hi..my husband was initially diagnosed stage 4b in 2020. He did well on chemo, and lupron. He is also on xgeva. He then went on zytiga for about 7 months before it started failing. He did get accepted in the luteciun trial at Penn on control arm. He did very well on Xtandi but was ended this past Aug
Happy1985
in
Advanced Prostate Cancer
9 months ago
Ketogenic diet for High risk PCA? American Ginseng for fatigue?
Reaching out for feedback regarding adopting a more ketogenic diet for my husband and using an american ginseng supplement for fatigue. Worth while? Husband is Gleason 9, PSA 46.6 when diagnosed, completed 28 Proton treatments, on Orgovyx and started Abiraterone and prednisone recently. Being treated
Reaching out for feedback regarding adopting a more ketogenic diet for my husband and using an american ginseng supplement for fatigue. Worth while? Husband is Gleason 9, PSA 46.6 when diagnosed, completed 28 Proton treatments, on Orgovyx and started Abiraterone and prednisone recently. Being treated
CancerConcierge
in
Advanced Prostate Cancer
9 months ago
Confusing news from oncologist
Hi all, looking for some insight or direction based off of any experiences or similar ones. My dad started chemo in October with a PSA of 126. After 2 rounds of chemo, his PSA rose to 153, we saw some increase in his bone metastasis as according to the scans (posted about this previously). My dad
Hi all, looking for some insight or direction based off of any experiences or similar ones. My dad started chemo in October with a PSA of 126. After 2 rounds of chemo, his PSA rose to 153, we saw some increase in his bone metastasis as according to the scans (posted about this previously). My dad
StayingSTRNG
in
Advanced Prostate Cancer
9 months ago
Still confused about PSA and Testosterone testing
I have been reading posts here for some time and there seems to be a split between those who only get PSA tests each time they go to their doctors and those that get both tests each time. I had a baseline testosterone test before Lupron and before radiation. I am now doing my 6 month follow up and
I have been reading posts here for some time and there seems to be a split between those who only get PSA tests each time they go to their doctors and those that get both tests each time. I had a baseline testosterone test before Lupron and before radiation. I am now doing my 6 month follow up and
Mgtd
in
Advanced Prostate Cancer
9 months ago
Sterlings Reply
Please forgive the lateness but here it is:Four years after prostectomy my psa began to rise. I had eight weeks of radiation to the prostate bed. Psa returned to nondetectable for eleven years. Two years ago my psa began to rise at an alarming rate it was doubling monthly if not more. I started eligard
Please forgive the lateness but here it is:Four years after prostectomy my psa began to rise. I had eight weeks of radiation to the prostate bed. Psa returned to nondetectable for eleven years. Two years ago my psa began to rise at an alarming rate it was doubling monthly if not more. I started eligard
Praying2BHealthy
in
Advanced Prostate Cancer
9 months ago
Blood in Urine
Hi fellow fighters Had blood in my urine the last 10 days. Hoped it was a UTI but a course of antibiotics has failed. I had a bladder neck incision last June to help urinary flow. The urologist saw a suspicious patch and a biopsy confirmed it my prostate cancer has spread to my bladder. I’m hoping
Hi fellow fighters Had blood in my urine the last 10 days. Hoped it was a UTI but a course of antibiotics has failed. I had a bladder neck incision last June to help urinary flow. The urologist saw a suspicious patch and a biopsy confirmed it my prostate cancer has spread to my bladder. I’m hoping
Tonyliv
in
Advanced Prostate Cancer
9 months ago
Did not see that coming.
Hello to all, Dx 11-1-23. Went in with urinary situations and came out with a Turp and stage 4. had a Psma pet scan ..Mets here and there . So high volume I guess. PSA was 139 ..MO says triplet therapy ....seems like I'm pretty far down the road... I know I gain by doing the therapy but on average are
Hello to all, Dx 11-1-23. Went in with urinary situations and came out with a Turp and stage 4. had a Psma pet scan ..Mets here and there . So high volume I guess. PSA was 139 ..MO says triplet therapy ....seems like I'm pretty far down the road... I know I gain by doing the therapy but on average are
APK3
in
Advanced Prostate Cancer
9 months ago
Importance of ADT
Are there any good outcomes without using ADT ( hormone therapy)? I delayed it for a couple of years with bad results. My history -- [u]
2021
[/u]: Age 78. PSA was 7.79, Gleason 4+3=7. Small lesion in prostate, with perineural invasion. Had 20 IMRT for prostate. No ADT. [u]
2022
[/u]: PSA
Are there any good outcomes without using ADT ( hormone therapy)? I delayed it for a couple of years with bad results. My history -- [u]
2021
[/u]: Age 78. PSA was 7.79, Gleason 4+3=7. Small lesion in prostate, with perineural invasion. Had 20 IMRT for prostate. No ADT. [u]
2022
[/u]: PSA
vintage42
in
Advanced Prostate Cancer
9 months ago
Next steps after PBRT
Hi all - First and foremost, Happy Holidays. I had my prostate removed 8/22, with subsequent Proton Beam treatment ending 4/23 (after PSA did not drop to undetectable) brought upon after a mild uptake (during a Petscan) in an obturator lymph node. I’m on Orgovyx and Xtandi, with a plan to stay on them
Hi all - First and foremost, Happy Holidays. I had my prostate removed 8/22, with subsequent Proton Beam treatment ending 4/23 (after PSA did not drop to undetectable) brought upon after a mild uptake (during a Petscan) in an obturator lymph node. I’m on Orgovyx and Xtandi, with a plan to stay on them
Vp7174
in
Advanced Prostate Cancer
9 months ago
Update following Cardiology appointment
Firstly thank you all for your responses to my question last week. I attended my appointment yesterday fully armed with a list of long questions which I was determined to get answered before I left. My Cardiologist advised that my Echocardiogram showed y heart wea in a good shape. However the results
Firstly thank you all for your responses to my question last week. I attended my appointment yesterday fully armed with a list of long questions which I was determined to get answered before I left. My Cardiologist advised that my Echocardiogram showed y heart wea in a good shape. However the results
Nosila07
in
AF Association
1 year ago
How do we determine if cancer is in remission
Just had my fourth of five Cyber Knife treatments and my doctor said everything has been going "great." It turns out that means when the treatment was performed my bladder was full and my rectum was empty. When I asked if another Petscan was on the horizon he told me that it was unlikely that my insurer
Just had my fourth of five Cyber Knife treatments and my doctor said everything has been going "great." It turns out that means when the treatment was performed my bladder was full and my rectum was empty. When I asked if another Petscan was on the horizon he told me that it was unlikely that my insurer
GrantB47
in
Advanced Prostate Cancer
9 months ago
What testosterone test should I get in my final blood test prior to HT starting?
Hi All, I intend on getting my own blood test that will form the baseline for how the future HT is working. When it comes to getting testosterone tests, I note there are a few to select from. Which one should I get from the following list? 1: Testosterone Free/Total + SHBG 2: Testosterone Total
Hi All, I intend on getting my own blood test that will form the baseline for how the future HT is working. When it comes to getting testosterone tests, I note there are a few to select from. Which one should I get from the following list? 1: Testosterone Free/Total + SHBG 2: Testosterone Total
CJ1958
in
Prostate Cancer Network
9 months ago
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