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PROTACs: another technique to help with mCRPC
I always wondered, if these protein degraders can basically destroy AR receptors, hence overcome both castration resistance and making the cells refractory to androgens...wouldn't it be useless to continue with ADT? Oh well... https://www.sciencedirect.com/science/article/pii/S0753332222015013
I always wondered, if these protein degraders can basically destroy AR receptors, hence overcome both castration resistance and making the cells refractory to androgens...wouldn't it be useless to continue with ADT? Oh well... https://www.sciencedirect.com/science/article/pii/S0753332222015013
Maxone73
in
Advanced Prostate Cancer
7 months ago
Results of MRI
So saw the endometriosis consultant today and he was very good. My MRI scan came back and showed extensive endometriosis that has obliterated my Pouch of Douglas and fully attached my rectum and bowel to my cervix. I've got an endo cyst on my left ovary and blood in left fallopian tube. Cervix is swollen
So saw the endometriosis consultant today and he was very good. My MRI scan came back and showed extensive endometriosis that has obliterated my Pouch of Douglas and fully attached my rectum and bowel to my cervix. I've got an endo cyst on my left ovary and blood in left fallopian tube. Cervix is swollen
Sunset-lady
in
Endometriosis UK
7 months ago
Hrt terrible sweats
I am sweating really bad being on zumenon for 4 months and nothing stopping it would like some advice plz
I am sweating really bad being on zumenon for 4 months and nothing stopping it would like some advice plz
Lauramcknight
in
PMRGCAuk
7 months ago
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Help with blood results
I recently posted here for advice on whether I need levothyroxine as I have been subclinical for 10 years and now my tsh seems to be creeping up the last few weeks from 4.88 to 5.59 and now 6.15 all in the space of 3/4 weeks. I wonder if it is linked to the introduction of testosterone, I started hrt
I recently posted here for advice on whether I need levothyroxine as I have been subclinical for 10 years and now my tsh seems to be creeping up the last few weeks from 4.88 to 5.59 and now 6.15 all in the space of 3/4 weeks. I wonder if it is linked to the introduction of testosterone, I started hrt
Rambler16
in
Thyroid UK
7 months ago
What is role of hormonal therapy drug when taken with targeted therapy, eg Piqray or Ibrance?
I’ve been curious about this and wondering if anyone can explain. I want to better understand the role of the hormone therapy eg Faslodex when taken with targeted therapy such as Ibrance. Does it just reduce the amount of estrogen available to the cell and “lightens the load” on the targeted therapy?
I’ve been curious about this and wondering if anyone can explain. I want to better understand the role of the hormone therapy eg Faslodex when taken with targeted therapy such as Ibrance. Does it just reduce the amount of estrogen available to the cell and “lightens the load” on the targeted therapy?
HelenWi
in
SHARE Metastatic Breast Cancer
9 months ago
3,100 PSA!
After two (2) Pluvicto infusions, my PSA went from 2,000. to 3,000. I haven't had any hormone treatments for approximately six months, and was subsequently told my Dr. should have kept me on Standard of Care (SoC) right through Pluvicto. Q1: Anyone out there know of any options open to me in this
After two (2) Pluvicto infusions, my PSA went from 2,000. to 3,000. I haven't had any hormone treatments for approximately six months, and was subsequently told my Dr. should have kept me on Standard of Care (SoC) right through Pluvicto. Q1: Anyone out there know of any options open to me in this
fsiefert
in
Advanced Prostate Cancer
7 months ago
help please - severe osteoporosis-3.5 on DEXA scan I’m just 48
hi hi Results DEXA Basically osteoporosis with ranges between -2.5 and -3.5 t score last thyroid T4 - 19 (12 to 22) Tsh - less than 0.01 T3 5.8 (4.1 to 6.8) my range at hospital is 4.1 to 6.8 previous to starting t3 med my t3 was 2.1 - probsbly for years! I haven’t started hrt so no wonder
hi hi Results DEXA Basically osteoporosis with ranges between -2.5 and -3.5 t score last thyroid T4 - 19 (12 to 22) Tsh - less than 0.01 T3 5.8 (4.1 to 6.8) my range at hospital is 4.1 to 6.8 previous to starting t3 med my t3 was 2.1 - probsbly for years! I haven’t started hrt so no wonder
Chouchou1234
in
Thyroid UK
7 months ago
Lump on buttocks due to FULVESTRANT injection
My mom is diagnosed with stage 4 breast cancer .. currently she is on her hormonal therapy ..FULVESTRANT injection are injected ....the injections are injected on buttocks ..due to this there is lump on her buttocks, but its not going away , even after all the cold , hot compress..so what should i do
My mom is diagnosed with stage 4 breast cancer .. currently she is on her hormonal therapy ..FULVESTRANT injection are injected ....the injections are injected on buttocks ..due to this there is lump on her buttocks, but its not going away , even after all the cold , hot compress..so what should i do
Hidden
in
Breast Cancer India
7 months ago
PSA of <0.1 undetectable?
I am on ADT, lupron and Zytiga, at Kaiser Oakland. My latest PSA came back as <0.1. My MO sent me a message with the results: "congratulations, great news, your PSA is undetectable!" I thought undetectable was 0.01, is it more likely she misread the number or that the lab used by Kaiser only reports
I am on ADT, lupron and Zytiga, at Kaiser Oakland. My latest PSA came back as <0.1. My MO sent me a message with the results: "congratulations, great news, your PSA is undetectable!" I thought undetectable was 0.01, is it more likely she misread the number or that the lab used by Kaiser only reports
pj1121
in
Advanced Prostate Cancer
7 months ago
Working with Stage IV
First time posting (be gentle) Anybody else still at work with the disease. I’ve contributed to a pension for 24 years, and with being diagnosed, am I being foolish staying at work. Note-minimum retirement is 58 at my work. Also, did read this right, ADT only gives about 10 mos. to 1 year increase
First time posting (be gentle) Anybody else still at work with the disease. I’ve contributed to a pension for 24 years, and with being diagnosed, am I being foolish staying at work. Note-minimum retirement is 58 at my work. Also, did read this right, ADT only gives about 10 mos. to 1 year increase
BigJ32
in
Advanced Prostate Cancer
6 months ago
PSA results After 5Cycles of pBAT
Everything looking good after 5 cycles of propionate BAT. Refresher: HSPC, did1 year ADT Lupron-->Orgovyx + Darolutamide before embarking on pBAT. Is this chart readable
Everything looking good after 5 cycles of propionate BAT. Refresher: HSPC, did1 year ADT Lupron-->Orgovyx + Darolutamide before embarking on pBAT. Is this chart readable
KocoPr
in
Fight Prostate Cancer
7 months ago
Diagnosis and menopause
So yesterday was the day I got my scan done by the gynecology consultant she was very good and explained everything. I have alot of blood flow to my uterus and I have adenomyosis present in the back wall of my uterus. Part of me was shocked as I didn't think I'd have it deep down but It was confirmed
So yesterday was the day I got my scan done by the gynecology consultant she was very good and explained everything. I have alot of blood flow to my uterus and I have adenomyosis present in the back wall of my uterus. Part of me was shocked as I didn't think I'd have it deep down but It was confirmed
En89
in
Endometriosis UK
7 months ago
Can i take vacation when already 5 years PSA < 0.01
Cancer of the prostate and pelvic lymph nodes found with PET 1, MRI, biopsy, PSA=100. - After 6 cycles of chemotherapy with docetaxel and ADT-ELIGARD with PET 2 and PET 3 show a rapid decrease in the size of the lymph nodes and their emission of SUV, as well as the disappearance of several of them
Cancer of the prostate and pelvic lymph nodes found with PET 1, MRI, biopsy, PSA=100. - After 6 cycles of chemotherapy with docetaxel and ADT-ELIGARD with PET 2 and PET 3 show a rapid decrease in the size of the lymph nodes and their emission of SUV, as well as the disappearance of several of them
Vasili
in
Advanced Prostate Cancer
7 months ago
spinal cord stimulator side effects
I wanted to know has anyone experienced itching skin ( mine is on my shoulder blades) following having a spinal cord stimulator fitted. I had mine fitted in 2018 and for some years now both my shoulder blades itch nearly all the time and drive me crazy, there is no rash or sign of anything on the skin
I wanted to know has anyone experienced itching skin ( mine is on my shoulder blades) following having a spinal cord stimulator fitted. I had mine fitted in 2018 and for some years now both my shoulder blades itch nearly all the time and drive me crazy, there is no rash or sign of anything on the skin
vihkins
in
Pain Concern
1 year ago
No stamina
I am confident I have my thyroid hormones at right level and most of my symptoms are gone. I am slowly losing weight, alert, happy, skin is better. My arthritis plays up hence the inflammation but my main issue is lack of stamina. I can only really do one thing a day after which I am wiped out and need
I am confident I have my thyroid hormones at right level and most of my symptoms are gone. I am slowly losing weight, alert, happy, skin is better. My arthritis plays up hence the inflammation but my main issue is lack of stamina. I can only really do one thing a day after which I am wiped out and need
Hectorsmum2
in
Thyroid UK
7 months ago
methotrexate
I am currently on hydroxychloroquine and my doctor wants me to move to Methotrexate . I am stil getting hand pain and foot pain ect on the hydroxy.... The side effects of all these drugs terrifies me.. Anyone on Methotrexate and like it? Do you have more energy? Do you drink alcohol...Hair falling out
I am currently on hydroxychloroquine and my doctor wants me to move to Methotrexate . I am stil getting hand pain and foot pain ect on the hydroxy.... The side effects of all these drugs terrifies me.. Anyone on Methotrexate and like it? Do you have more energy? Do you drink alcohol...Hair falling out
tresa56
in
NRAS
9 months ago
Favorite RA drug? I have so much anxiety about trying a new one
I am currently on hydroxychloroquine and my doctor wants me to move to Methotrexate . I am stil getting hand pain and foot pain ect on the hydroxy.... The side effects of all these drugs terrifies me.. Anyone on Methotrexate and like it? Do you have more energy? Do you drink alcohol...Hair falling
I am currently on hydroxychloroquine and my doctor wants me to move to Methotrexate . I am stil getting hand pain and foot pain ect on the hydroxy.... The side effects of all these drugs terrifies me.. Anyone on Methotrexate and like it? Do you have more energy? Do you drink alcohol...Hair falling
tresa56
in
FieryBones - RA Community
9 months ago
6 years now and PSA <0.01 is it time for a vacation?
Hello, after chemotherapy, STRT of the prostate, I have been taking Eligard hormone therapy for 6 years now and PSA <0.01 is it time for a vacation?
Hello, after chemotherapy, STRT of the prostate, I have been taking Eligard hormone therapy for 6 years now and PSA <0.01 is it time for a vacation?
Vasili
in
Advanced Prostate Cancer
7 months ago
How long symptoms stay
hi I had 1 injection of Prostap end of sept and unfortunately I suffered with, headaches, insomnia, no appetite. I became really depressed and anxious as well. My dr said it works in your system 5/6 weeks and then stops and will start to leave my body. So I’m 4 weeks now past that. I’m just trying
hi I had 1 injection of Prostap end of sept and unfortunately I suffered with, headaches, insomnia, no appetite. I became really depressed and anxious as well. My dr said it works in your system 5/6 weeks and then stops and will start to leave my body. So I’m 4 weeks now past that. I’m just trying
Lothead01
in
Endometriosis UK
7 months ago
PSA slightly rose after 8 months undetectable
I am 57 and on ADT (Firmagon+Zytiga+Prednisone) after surgery in 2022 and 39 sessions of RT in 2023 (Jan Feb). Till now I has been undetectable but at November my bloodwork showed PSA risen to 0.04. Should I be concerned or could it be just random fluctuation? Thanks for your reactions.
I am 57 and on ADT (Firmagon+Zytiga+Prednisone) after surgery in 2022 and 39 sessions of RT in 2023 (Jan Feb). Till now I has been undetectable but at November my bloodwork showed PSA risen to 0.04. Should I be concerned or could it be just random fluctuation? Thanks for your reactions.
noasim
in
Advanced Prostate Cancer
7 months ago
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