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Clemastine (Tavegyl), an over-the-counter drug, found to be effective at inducing LMP and cell death
For what it may be worth, thougbt some of you might like to see this: "Lysosomes in chronic lymphocytic leukemia (CLL) cells have previously been identified as a promising target for therapeutic intervention in combination with targeted therapies. Recent studies have shown that antihistamines can induce
For what it may be worth, thougbt some of you might like to see this: "Lysosomes in chronic lymphocytic leukemia (CLL) cells have previously been identified as a promising target for therapeutic intervention in combination with targeted therapies. Recent studies have shown that antihistamines can induce
Pogee
in
CLL Support
4 years ago
HCG level
Hi, I had my bloods done on Wednesday, I was 14dp5ft and they came back today as 1503.. Is this a good number? Does it indicate anything? Thank you
Hi, I had my bloods done on Wednesday, I was 14dp5ft and they came back today as 1503.. Is this a good number? Does it indicate anything? Thank you
HopeIVFul
in
Fertility Network UK
4 years ago
T cell leukemia
Just diagnosed with T cell leukemia, I do not have a subtype yet. Any other T cell types out there?
Just diagnosed with T cell leukemia, I do not have a subtype yet. Any other T cell types out there?
Mom-mom-e
in
CLL Support
4 years ago
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Imbruvica-related issues: Qs + comments
The following are questions and comments I'll be asking my oncologist when I see him tomorrow. I believe at least some of them might be relevant to what some among us are experiencing and research some of us are engaging in. Clearly, none of the comments here are meant to be authoritative nor intended
The following are questions and comments I'll be asking my oncologist when I see him tomorrow. I believe at least some of them might be relevant to what some among us are experiencing and research some of us are engaging in. Clearly, none of the comments here are meant to be authoritative nor intended
Pogee
in
CLL Support
4 years ago
HCG Intra-uterine flushing - Update
HCG Intra-uterine flushing - Update Hello everybody, So I had the HCG flushing 2 days ago and had my transfer today. It is pretty much like an embryo transfer but the catheter contains a few ml of the HCG hormone (500) in a medium which is then squirted into the uterus. This is still experimental
HCG Intra-uterine flushing - Update Hello everybody, So I had the HCG flushing 2 days ago and had my transfer today. It is pretty much like an embryo transfer but the catheter contains a few ml of the HCG hormone (500) in a medium which is then squirted into the uterus. This is still experimental
Bozo_the_pumpkin
in
Fertility Network UK
4 years ago
Question about doubling hcg
so, I stopped trying for a while with no luck. My periods are usually very regular (my last one being July 20). I missed my period completely in August with several negative HPTs after my expected period. I finally got a blood test on Thursday, Sept 3 and my hcg level was 5. I just assumed that was a
so, I stopped trying for a while with no luck. My periods are usually very regular (my last one being July 20). I missed my period completely in August with several negative HPTs after my expected period. I finally got a blood test on Thursday, Sept 3 and my hcg level was 5. I just assumed that was a
Britt2028
in
Fertility Network UK
4 years ago
BFP after miscarriage
I've just got a postive on a hcg urine test after a frozen cycle, following on from a previous cycle where I also got pregnant but sadly miscarried at 5 weeks. We've been trying for almost three years, and with the previous miscarriage I don't know how to relax and not expect the worse again. Has anyone
I've just got a postive on a hcg urine test after a frozen cycle, following on from a previous cycle where I also got pregnant but sadly miscarried at 5 weeks. We've been trying for almost three years, and with the previous miscarriage I don't know how to relax and not expect the worse again. Has anyone
Dylan88
in
Fertility Network UK
4 years ago
FCR
I’ll avoid FCR at all. Dangerous and tricky. Increase the probability of AL occurrence as well as second neoplasm and Richter transformation in the long run. You have to be "fit patient” to receive FCR, IGHV mutated and without tp53 mutation or 17p deletion. Find a responsible doctor with a robust experience
I’ll avoid FCR at all. Dangerous and tricky. Increase the probability of AL occurrence as well as second neoplasm and Richter transformation in the long run. You have to be "fit patient” to receive FCR, IGHV mutated and without tp53 mutation or 17p deletion. Find a responsible doctor with a robust experience
Rccfrc00
in
CLL Support
4 years ago
flair ..fcr
hi all i have had cll from 2012 i have been on w&w my question is i have signed up for the flair trail Manchester Christie i got phone call this week saying i was randomized for FCR my age is 57yrs i have no tp53 or any other abnormal readings and i dont know what my mutations are etc mutated or unmutated
hi all i have had cll from 2012 i have been on w&w my question is i have signed up for the flair trail Manchester Christie i got phone call this week saying i was randomized for FCR my age is 57yrs i have no tp53 or any other abnormal readings and i dont know what my mutations are etc mutated or unmutated
kel555
in
CLL Support
4 years ago
Documented remission without drugs
I've just come across an article on a remarkable, well-documented, case of a younger man with CLL who, over time, achieved complete remission without drugs. Here's the link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4739749/ * I hasten to add that this is but a single case, and I'm not recommending
I've just come across an article on a remarkable, well-documented, case of a younger man with CLL who, over time, achieved complete remission without drugs. Here's the link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4739749/ * I hasten to add that this is but a single case, and I'm not recommending
Pogee
in
CLL Support
4 years ago
Article performing a clinical trial using T3-sulphate instead of T3 alone in a combination T4/T3 setting
This article has tested the stability in use of T3-sulphate rather than T3 alone for combination therapy. The T3-sulphate gives a much more even response than T3 only, and lowers the "spiking" seen shortly after taking.
CLINICAL TRIAL ARTICLE
Front. Endocrinol., 29 November 2019 |
https
This article has tested the stability in use of T3-sulphate rather than T3 alone for combination therapy. The T3-sulphate gives a much more even response than T3 only, and lowers the "spiking" seen shortly after taking.
CLINICAL TRIAL ARTICLE
Front. Endocrinol., 29 November 2019 |
https
diogenes
in
Thyroid UK
4 years ago
BFP but..... scared
Hi Ladies, Im 40 years and had my first transfer 22nd august. I got a faint positive Thursday 3rd sept so was asked to have a hcg blood test, the results show positive hcg level 29. Now ive been asked to go for another blood test monday. i am so worried the level is too low or wont rise. its a dream
Hi Ladies, Im 40 years and had my first transfer 22nd august. I got a faint positive Thursday 3rd sept so was asked to have a hcg blood test, the results show positive hcg level 29. Now ive been asked to go for another blood test monday. i am so worried the level is too low or wont rise. its a dream
lou12208
in
Fertility Network UK
4 years ago
*Sensitive Post* Viability Scan after low HCG
Hi ladies, So it’s finally my time to share a scan picture. It’s been a rocky few weeks starting with low HCG levels, some bleeding & my first scan without a heartbeat. But the little peanut is all caught up & measuring bang on 7 weeks, still early days but allowing myself a bit of excitement! I had
Hi ladies, So it’s finally my time to share a scan picture. It’s been a rocky few weeks starting with low HCG levels, some bleeding & my first scan without a heartbeat. But the little peanut is all caught up & measuring bang on 7 weeks, still early days but allowing myself a bit of excitement! I had
Chloettc2020
in
Fertility Network UK
4 years ago
Can Venetoclax/Obinituzimab reduce the risk of additional somatic mutations? - Not necessarily. The BTK inhibitors are excellent at....
Below is a repost from CLLSLL@groups.io ( permission granted by Dr. Furman) - I believe this hypothesis may be tested in a proposed clinical trial Dr. Furman has mentioned in the past- Len - Can Venetoclax/Obinituzimab reduce the risk of additional somatic mutations? From: ------ Date: Thu, 23 Jul
Below is a repost from CLLSLL@groups.io ( permission granted by Dr. Furman) - I believe this hypothesis may be tested in a proposed clinical trial Dr. Furman has mentioned in the past- Len - Can Venetoclax/Obinituzimab reduce the risk of additional somatic mutations? From: ------ Date: Thu, 23 Jul
lankisterguy
Volunteer
in
CLL Support
4 years ago
Resistance-Associated Mutations in CLL Patients Treated With Novel Agents
This is slightly complex but good overview of the acquired resistance mechanisms to novel agents. In 80% of patients with ibrutinib failure, acquired mutations in BTK and PLCG2 genes were detected. No common resistance-associated mutations or deregulated signaling pathways have been reported in idelalisib
This is slightly complex but good overview of the acquired resistance mechanisms to novel agents. In 80% of patients with ibrutinib failure, acquired mutations in BTK and PLCG2 genes were detected. No common resistance-associated mutations or deregulated signaling pathways have been reported in idelalisib
Jm954
Administrator
in
CLL Support
4 years ago
HCG levels ?
Hi ladies . Got my bfp yesterday and had hCG checked with GP . Came back at 36iu .. at 4 weeks +4 days .. should I be worried ?
Hi ladies . Got my bfp yesterday and had hCG checked with GP . Came back at 36iu .. at 4 weeks +4 days .. should I be worried ?
Zen37
in
Pregnancy and Parenting Support
4 years ago
Bleeding and miscarried 😢
How can something that was apart of me for just a month leave such sorrow. Viability scan was booked for tomorrow (4th). Last Saturday woke up feeling like I had no energy at all. Went to the loo and noticed bleeding. Contacted my emergency out of hours number who told me to call the hospital on Monday
How can something that was apart of me for just a month leave such sorrow. Viability scan was booked for tomorrow (4th). Last Saturday woke up feeling like I had no energy at all. Went to the loo and noticed bleeding. Contacted my emergency out of hours number who told me to call the hospital on Monday
JeSs8819
in
Fertility Network UK
4 years ago
Preparing for a new chapter
Hello everyone, I’m not use to being on forums but I feel so lost and alone, I don’t know who else to turn to. I’m 28 years old and the oldest daughter of my family. We recently found out my mom (52) is at her end stage of renal disease. She just had a catheter inserted to prepare for Peritoneal Dialysis
Hello everyone, I’m not use to being on forums but I feel so lost and alone, I don’t know who else to turn to. I’m 28 years old and the oldest daughter of my family. We recently found out my mom (52) is at her end stage of renal disease. She just had a catheter inserted to prepare for Peritoneal Dialysis
AC320
in
Kidney Dialysis
4 years ago
Richter transformation after quitting ibrutinib: a diagnostic error
Hi all. The topic of the connection between Ibrutinib and the Richter transformation is getting very interesting. In the group that I have on Facebook every day people are entering that once Ibrutinib left a few days for an operation or biopsy for another movement, Richter was diagnosed. Then the Pet
Hi all. The topic of the connection between Ibrutinib and the Richter transformation is getting very interesting. In the group that I have on Facebook every day people are entering that once Ibrutinib left a few days for an operation or biopsy for another movement, Richter was diagnosed. Then the Pet
Priss69
in
CLL Support
4 years ago
2 Lung Diseases and falling apart
Hello my name is Annie. I joined yesterday but gave up as when writing about my condition it allowed me to put Pulmonary Fibrosis, not my main lung disease hypersensitivity pneumonitis why is this? Also not sure which help site I belong to as a result of my lungs I have had Chronic Heart Failure 2
Hello my name is Annie. I joined yesterday but gave up as when writing about my condition it allowed me to put Pulmonary Fibrosis, not my main lung disease hypersensitivity pneumonitis why is this? Also not sure which help site I belong to as a result of my lungs I have had Chronic Heart Failure 2
Hidden
in
Lung Conditions Community Forum
4 years ago
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