Article performing a clinical trial using T3-sulphate instead of T3 alone in a combination T4/T3 setting

[diogenes]

This article has tested the stability in use of T3-sulphate rather than T3 alone for combination therapy. The T3-sulphate gives a much more even response than T3 only, and lowers the "spiking" seen shortly after taking.

CLINICAL TRIAL ARTICLE

Front. Endocrinol., 29 November 2019 | doi.org/10.3389/fendo.2019....

Treatment of Hypothyroid Patients With L-Thyroxine (L-T4) Plus Triiodothyronine Sulfate (T3S). A Phase II, Open-Label, Single Center, Parallel Groups Study on Therapeutic Efficacy and Tolerability

Ferruccio Santini, Giovanni Ceccarini, Caterina Pelosini, Monica Giannetti, Ilaria Ricco, Giorgia Querci, Enzo Grossi, Giorgio Saponati and Paolo Vitti

[Rosannaclare]

Thanks as usual for sharing diogenes - really useful when looking at T3

[diogenes Remembering]

I did in fact post this 8 months ago. but I thought it worthwhile to show there are better possibilities in dosage today which should now be closer to therapeutic realisation.

[asidist in reply to diogenes]

thanks for sharing diogenes. do you have any knowledge or thoughts as to when t3-sulfate might become available as a prescription? eg months vs years?

[diogenes Remembering in reply to asidist]

As per European and general medical rules, T3 sulphate will have to go through stages 1,2 and 3 of clinical trials. The paper might be considered stage 1, but safety in use has to be established as well as its medical ability for treating the disease in a formal clinical trial. This will take some years but I don't know how many. It depends on the outcome of stages 1 and 2.

[helvella in reply to diogenes]

Repetition is entirely acceptable, even desirable.

Few of us, if any, read all posts here, however hard we try.

Frequently, reading the same basic story months or years later, acts as a reminder and a stimulus and reinforces the story itself making it more likely to be remembered in the future.

[diogenes Remembering]

As well as this there is a commentary by Wiersinga on progress in combination therapy possibilities:

Endocrine. 2019; 66(1): 70–78.

Published online 2019 Oct 15. doi: 10.1007/s12020-019-02052-2

PMCID: PMC6794355

PMID: 31617166

T4 + T3 combination therapy: any progress?

Wilmar M. Wiersinga

[Hidden]

Excellent, thank you diogenes, helpful as always

[Hidden]

Good to know, and a further reason not to dismiss T3 as too dangerous to use!

[WildDeer]

Thanks Diogenes,

Would T3-sulphate also be likely to help people on T3 only, like myself, to keep steady?

[diogenes Remembering in reply to WildDeer]

Yes, it would lower the size of the T3 "spike" shortly after taking T3 alone.

[Stourie in reply to diogenes]

Hi , just wondering why I've never felt a spike when on t3 only. I even made a mistake once and took 80mcg at bedtime and then not thinking did the same the next morning and felt no different. I was waiting for the jitters but absolutely nothing. Cheers. Jo xx

[diogenes Remembering in reply to Stourie]

Probably because you were only "hyperthyroid" for an hour or so. In that time the body couldn't respond to the overdose, before it ebbed away. I think it's long term FT3 elevation that has the effect, not one that normalises after a few hours.