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BRCA-2, etc, in CRPC.
Abstract Toward development of a precision medicine framework for metastatic,
castration
-resistant prostate cancer (mCRPC), we established a multi-institutional clinical sequencing infrastructure to conduct prospective whole-exome and transcriptome sequencing of bone or soft tissue tumor biopsies from
Abstract Toward development of a precision medicine framework for metastatic,
castration
-resistant prostate cancer (mCRPC), we established a multi-institutional clinical sequencing infrastructure to conduct prospective whole-exome and transcriptome sequencing of bone or soft tissue tumor biopsies from
pjoshea13
in
Advanced Prostate Cancer
7 years ago
Natural killer cells suppress enzalutamide resistance and cell invasion in CRPC via targeting ARv7.
"Despite the success of androgen-deprivation therapy (ADT) with the newly developed anti-androgen enzalutamide (Enz, also known as MDV3100) to suppress
castration
resistant prostate cancer (CRPC) in extending patient survival by an extra 4.8 months ..."
"Despite the success of androgen-deprivation therapy (ADT) with the newly developed anti-androgen enzalutamide (Enz, also known as MDV3100) to suppress
castration
resistant prostate cancer (CRPC) in extending patient survival by an extra 4.8 months ..."
pjoshea13
in
Advanced Prostate Cancer
7 years ago
Steroid receptor coactivators
Abstract Medical or surgical
castration
serves as the backbone of systemic therapy for advanced and metastatic prostate cancer, taking advantage of the importance of androgen signaling in this disease. Unfortunately, resistance to
castration
emerges almost universally.
Abstract Medical or surgical
castration
serves as the backbone of systemic therapy for advanced and metastatic prostate cancer, taking advantage of the importance of androgen signaling in this disease. Unfortunately, resistance to
castration
emerges almost universally.
pjoshea13
in
Advanced Prostate Cancer
7 years ago
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Bone Marrow Transplant for MCRPC
My next clinical trial is 'Sex-Mismatched Allogeneic Bone Marrow Transplantation for Men With Metastatic
Castration
-Resistant Prostate Cancer' https://clinicaltrials.gov/ct2/show/NCT02995330 I hear the the chance of dying from the transplant is 10% during the first six months, but gets lower as time
My next clinical trial is 'Sex-Mismatched Allogeneic Bone Marrow Transplantation for Men With Metastatic
Castration
-Resistant Prostate Cancer' https://clinicaltrials.gov/ct2/show/NCT02995330 I hear the the chance of dying from the transplant is 10% during the first six months, but gets lower as time
Beauxman
in
Advanced Prostate Cancer
7 years ago
Ground Flaxseed, Flaxsee Oil & Flaxseed Oil.
Was she aiming for lite-
castration
? Average PSA went up by 5% during the short intervention. However, it went down in the Gleason 6 or under cases. Notice Wendy's sleight of hand.
Was she aiming for lite-
castration
? Average PSA went up by 5% during the short intervention. However, it went down in the Gleason 6 or under cases. Notice Wendy's sleight of hand.
pjoshea13
in
Advanced Prostate Cancer
7 years ago
Prostate Cancer & Hormones - Estrogen [2] - Discovery of ERbeta.
Because of the absence of ERbeta from the adult pituitary and endometrium, ERbeta agonists can be used to target ERbeta with no risk of adverse effects from chemical
castration
and uterine cancer.
Because of the absence of ERbeta from the adult pituitary and endometrium, ERbeta agonists can be used to target ERbeta with no risk of adverse effects from chemical
castration
and uterine cancer.
pjoshea13
in
Advanced Prostate Cancer
7 years ago
ADT failure and measuring testosterone
I know at least one man who "failed" ADT (Lupron) and was thought to be "
castration
resistant". In fact however, when he got his testosterone measured it was 87 when the target number for his ADT treatment was 20. So he wasn't
castration
resistant at all.
I know at least one man who "failed" ADT (Lupron) and was thought to be "
castration
resistant". In fact however, when he got his testosterone measured it was 87 when the target number for his ADT treatment was 20. So he wasn't
castration
resistant at all.
AlanMeyer
in
Advanced Prostate Cancer
7 years ago
Prostate Cancer & Hormones - Insulin-like growth factor [IGF] axis.
When combined with
castration
, ganitumab showed a potent therapeutic effect and achieved a long period suppression of VCaP xenograft growth. Ganitumab alone did not have appreciable therapeutic effect in established
castration
-resistant CWR-22Rv1 xenograft tumor.
When combined with
castration
, ganitumab showed a potent therapeutic effect and achieved a long period suppression of VCaP xenograft growth. Ganitumab alone did not have appreciable therapeutic effect in established
castration
-resistant CWR-22Rv1 xenograft tumor.
pjoshea13
in
Advanced Prostate Cancer
7 years ago
Oligometastatic PCa & Treatment with Curative Intent
states and finally large-scale trials evaluating whether the approach, in combination with local therapy, can prevent or delay the time-to-event measures of disease progression or death in patients with ″high-risk″ tumors is no longer practical now that 6 life-prolonging systemic therapies in metastatic
castration
-resistant
states and finally large-scale trials evaluating whether the approach, in combination with local therapy, can prevent or delay the time-to-event measures of disease progression or death in patients with ″high-risk″ tumors is no longer practical now that 6 life-prolonging systemic therapies in metastatic
castration
-resistant
pjoshea13
in
Advanced Prostate Cancer
7 years ago
Maximum Hormone Blockade
It seems to me, from what I've read that becoming
castration
resistant, is the time that PCa goes from being a chronic illness to a life threatening situation.
It seems to me, from what I've read that becoming
castration
resistant, is the time that PCa goes from being a chronic illness to a life threatening situation.
paulofaus
in
Advanced Prostate Cancer
7 years ago
Live like you are dying.
Basically my treatment is a form of chemical
castration
; I receive an injection every 28 days. The psychological toll on me is great as I am a very sexual being. Performance anxiety is the single biggest problem I face.
Basically my treatment is a form of chemical
castration
; I receive an injection every 28 days. The psychological toll on me is great as I am a very sexual being. Performance anxiety is the single biggest problem I face.
Dave_D
in
Advanced Prostate Cancer
7 years ago
ADT + Chemo vs ADT followed by Chemo
ADT + Chemotherapy for men who are NOT
castration
resistant. http://www.nejm.org/doi/full/10.1056/NEJMoa1503747#t=articleTop If I understand the article, it found that time to progression and overall survival were both significantly longer in the dual therapy group.
ADT + Chemotherapy for men who are NOT
castration
resistant. http://www.nejm.org/doi/full/10.1056/NEJMoa1503747#t=articleTop If I understand the article, it found that time to progression and overall survival were both significantly longer in the dual therapy group.
AlanMeyer
in
Advanced Prostate Cancer
7 years ago
New York Times story
I was a bit puzzled by the PCa news in the Times this morning [1]: "Hormone Blockers Can Prolong Life if Prostate Cancer Recurs" "The medical term for blocking male hormones is chemical
castration
..."
I was a bit puzzled by the PCa news in the Times this morning [1]: "Hormone Blockers Can Prolong Life if Prostate Cancer Recurs" "The medical term for blocking male hormones is chemical
castration
..."
pjoshea13
in
Advanced Prostate Cancer
7 years ago
Abiraterone [Zytiga] & the Neutrophil-to-Lymphocyte Ratio [NLR]
KEYWORDS: abiraterone;
castration
-resistant prostate cancer; neutrophil-to-lymphocyte ratio; prognostic biomarker; treatment response PMID: 28208664 DOI: 10.3390/ijms18020380 [PubMed - in process]
KEYWORDS: abiraterone;
castration
-resistant prostate cancer; neutrophil-to-lymphocyte ratio; prognostic biomarker; treatment response PMID: 28208664 DOI: 10.3390/ijms18020380 [PubMed - in process]
pjoshea13
in
Advanced Prostate Cancer
7 years ago
Prognostic factors for Docetaxel [Taxotere] in CRPC
KEYWORDS:
Castration
-resistant prostate cancer; Chemotherapy; Docetaxel; Neutrophil-to-lymphocyte ratio; Northwestern China; Survival PMID: 28161841 DOI: 10.1007/s11255-017-1524-z [PubMed - as supplied by publisher]
KEYWORDS:
Castration
-resistant prostate cancer; Chemotherapy; Docetaxel; Neutrophil-to-lymphocyte ratio; Northwestern China; Survival PMID: 28161841 DOI: 10.1007/s11255-017-1524-z [PubMed - as supplied by publisher]
pjoshea13
in
Advanced Prostate Cancer
7 years ago
Role of free testosterone levels in mCRPC.
Abstract A range of new treatment options has recently become available for patients with advanced metastatic
castration
-resistant prostate cancer (mCRPC).
Abstract A range of new treatment options has recently become available for patients with advanced metastatic
castration
-resistant prostate cancer (mCRPC).
pjoshea13
in
Advanced Prostate Cancer
7 years ago
Guide Lines Your Oncologist Is Supposed To Follow..Wow..Read This and Know As Much As Most Docs
Or follow the Bollinger/Nalakrats Protocol of 24 Hour Continuous Imagery of Naked Women entitled "Die With a Smile on Your Face While On a Morphine Drip" Gus https://www.auanet.org/common/pdf/education/clinical-guidance/
Castration
-Resistant-Prostate-Cancer.pdf
Or follow the Bollinger/Nalakrats Protocol of 24 Hour Continuous Imagery of Naked Women entitled "Die With a Smile on Your Face While On a Morphine Drip" Gus https://www.auanet.org/common/pdf/education/clinical-guidance/
Castration
-Resistant-Prostate-Cancer.pdf
gusgold
in
Advanced Prostate Cancer
7 years ago
Seeking comments from those who had surgical castration.
Rather than the possibility of having testosterone once again feed prostate cancer cells that survived somewhere - it seems that surgical
castration
might help lower chances of recurrence - I am considering declining more lupron. Please let me know you experience with surgical
castration
.
Rather than the possibility of having testosterone once again feed prostate cancer cells that survived somewhere - it seems that surgical
castration
might help lower chances of recurrence - I am considering declining more lupron. Please let me know you experience with surgical
castration
.
Hidden
in
Advanced Prostate Cancer
8 years ago
AR-V7 - CTC's - Risk of Death
76% reduction in risk of death when taxane chemo was used in place of Xtandi or Zytiga Gus http://www.urotoday.com/recent-abstracts/urologic-oncology/mcrpc-treatment/93262-study-from-msk-and-epic-sciences-shows-only-nuclear-localized-ar-v7-is-predictive-of-therapy-benefit-for-patients-with-metastatic-
castration
-resistant-prostate-cancer-mcrpc.html
76% reduction in risk of death when taxane chemo was used in place of Xtandi or Zytiga Gus http://www.urotoday.com/recent-abstracts/urologic-oncology/mcrpc-treatment/93262-study-from-msk-and-epic-sciences-shows-only-nuclear-localized-ar-v7-is-predictive-of-therapy-benefit-for-patients-with-metastatic-
castration
-resistant-prostate-cancer-mcrpc.html
gusgold
in
Advanced Prostate Cancer
7 years ago
Abiraterone or Enzalutamide in Advanced CRPC.
[Epub ahead of print] Abiraterone or Enzalutamide in Advanced
Castration
-Resistant Prostate Cancer: An Indirect Comparison. Chopra A1, Georgieva M2, Lopes G3, Yeo CM1, Haaland B2.
[Epub ahead of print] Abiraterone or Enzalutamide in Advanced
Castration
-Resistant Prostate Cancer: An Indirect Comparison. Chopra A1, Georgieva M2, Lopes G3, Yeo CM1, Haaland B2.
pjoshea13
in
Advanced Prostate Cancer
7 years ago
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