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Castration
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New AR-V7 Test. German; simpler; cheaper(?).
[Epub ahead of print] AR-V7 in Peripheral Whole Blood of Patients with
Castration
-resistant Prostate Cancer: Association with Treatment-specific Outcome Under Abiraterone and Enzalutamide.
[Epub ahead of print] AR-V7 in Peripheral Whole Blood of Patients with
Castration
-resistant Prostate Cancer: Association with Treatment-specific Outcome Under Abiraterone and Enzalutamide.
pjoshea13
in
Advanced Prostate Cancer
7 years ago
Metformin & Xtandi Resistance.
These findings suggest that combination of metformin with enzalutamide could be a more efficacious therapeutic strategy for the treatment of
castration
-resistant prostate cancer. PMID: 28837141 DOI: 10.1038/cddis.2017.417
These findings suggest that combination of metformin with enzalutamide could be a more efficacious therapeutic strategy for the treatment of
castration
-resistant prostate cancer. PMID: 28837141 DOI: 10.1038/cddis.2017.417
pjoshea13
in
Advanced Prostate Cancer
7 years ago
PREVAIL Trial [Xtandi] - low-PSA cases
Abstract PURPOSE: Metastatic
castration
-resistant prostate cancer with low baseline prostate-specific antigen represents an early stage in the natural history of
castration
-resistant prostate cancer disease progression (low-volume disease), low prostate-specific antigen-producing disease, or disease
Abstract PURPOSE: Metastatic
castration
-resistant prostate cancer with low baseline prostate-specific antigen represents an early stage in the natural history of
castration
-resistant prostate cancer disease progression (low-volume disease), low prostate-specific antigen-producing disease, or disease
pjoshea13
in
Advanced Prostate Cancer
7 years ago
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Introduction
Now i,m looking at
castration
. I hope this isn't too gloomy of an intro. Thanks Wish you all well.
Now i,m looking at
castration
. I hope this isn't too gloomy of an intro. Thanks Wish you all well.
Oscar-
in
Advanced Prostate Cancer
7 years ago
Xtandi is costly in the Philippines
Hi im a newbie here, my dad is diagnosed with PCa stage 4, with bone mets,
castration
resistant since March of 2015, initially with PSA 500 and Gleason 9.
Hi im a newbie here, my dad is diagnosed with PCa stage 4, with bone mets,
castration
resistant since March of 2015, initially with PSA 500 and Gleason 9.
HannaMD
in
Advanced Prostate Cancer
7 years ago
FIRSTANA Trial - Cabazitaxel 20/25 mg v. Docetaxel 75 mg
Abstract Purpose In patients with metastatic
castration
-resistant prostate cancer (mCRPC), overall survival (OS) is significantly improved with cabazitaxel versus mitoxantrone after prior docetaxel treatment.
Abstract Purpose In patients with metastatic
castration
-resistant prostate cancer (mCRPC), overall survival (OS) is significantly improved with cabazitaxel versus mitoxantrone after prior docetaxel treatment.
pjoshea13
in
Advanced Prostate Cancer
7 years ago
Melatonin & AR-V7
Author information Abstract A major current challenge in the treatment of advanced prostate cancer, which can be initially controlled by medical or surgical
castration
, is the development of effective, safe, and affordable therapies against progression of the disease to the stage of
castration
resistance
Author information Abstract A major current challenge in the treatment of advanced prostate cancer, which can be initially controlled by medical or surgical
castration
, is the development of effective, safe, and affordable therapies against progression of the disease to the stage of
castration
resistance
pjoshea13
in
Advanced Prostate Cancer
7 years ago
Zytiga + Statins + CRPC
[Epub ahead of print] Statin Use and Survival in Patients with Metastatic
Castration
-resistant Prostate Cancer Treated with Abiraterone Acetate.
[Epub ahead of print] Statin Use and Survival in Patients with Metastatic
Castration
-resistant Prostate Cancer Treated with Abiraterone Acetate.
pjoshea13
in
Advanced Prostate Cancer
7 years ago
Resveratrol & ARV7
KEYWORDS: ARV7;
castration
resistance; polyubiquitination; prostate cancer; resveratrol PMID: 28589901 DOI: 10.18632/oncotarget.18003
KEYWORDS: ARV7;
castration
resistance; polyubiquitination; prostate cancer; resveratrol PMID: 28589901 DOI: 10.18632/oncotarget.18003
pjoshea13
in
Advanced Prostate Cancer
7 years ago
Ranolazine + Xtandi
For men who develop metastatic
castration
resistant PCa (mCRPC), survival is limited, making the identification of novel therapies for mCRPC critical.
For men who develop metastatic
castration
resistant PCa (mCRPC), survival is limited, making the identification of novel therapies for mCRPC critical.
pjoshea13
in
Advanced Prostate Cancer
7 years ago
Occult cancer in patients with deep-vein thrombosis [DVT].
It is fairly well-known that the old ADT treatment, diethylstilbestrol [DES], a synthetic estradiol, increased the risk for thromboembolic events, but it appears that
castration
therapy can also increase risk. Nattokinase can accelerate the breakdown of the fibrin in growing clots.
It is fairly well-known that the old ADT treatment, diethylstilbestrol [DES], a synthetic estradiol, increased the risk for thromboembolic events, but it appears that
castration
therapy can also increase risk. Nattokinase can accelerate the breakdown of the fibrin in growing clots.
pjoshea13
in
Advanced Prostate Cancer
7 years ago
Zytiga + Statins in CRPC
[Epub ahead of print] The impact of statin use on the efficacy of abiraterone acetate in patients with
castration
-resistant prostate cancer.
[Epub ahead of print] The impact of statin use on the efficacy of abiraterone acetate in patients with
castration
-resistant prostate cancer.
pjoshea13
in
Advanced Prostate Cancer
7 years ago
Keytruda
From a 2016 paper [3]: "While programmed cell death 1 (PD-1) inhibitors have shown clear anti-tumor efficacy in several solid tumors, prior results in men with metastatic
castration
resistant prostate cancer (mCRPC) showed no evidence of activity.
From a 2016 paper [3]: "While programmed cell death 1 (PD-1) inhibitors have shown clear anti-tumor efficacy in several solid tumors, prior results in men with metastatic
castration
resistant prostate cancer (mCRPC) showed no evidence of activity.
pjoshea13
in
Advanced Prostate Cancer
7 years ago
Docetaxel and nicotine
I have an aggressive metastatic
castration
resistant prostate cancer and have already gone through Zytiga and Xtandi.
I have an aggressive metastatic
castration
resistant prostate cancer and have already gone through Zytiga and Xtandi.
LP16
in
Advanced Prostate Cancer
7 years ago
STAMPEDE - Zytiga at ADT initiation. NEJM Paper.
These agents were initially investigated in men with very advanced disease whose tumors had progressed during first-line ADT, a disease state now termed
castration
-resistant prostate cancer.
These agents were initially investigated in men with very advanced disease whose tumors had progressed during first-line ADT, a disease state now termed
castration
-resistant prostate cancer.
pjoshea13
in
Advanced Prostate Cancer
7 years ago
free Testosterone [fT] & survival.
One possible incentive for the continuation of conventional ADT may lay in the assumption of a broader mode of therapy in the
castration
-resistant state. The mechanisms that lead to the
castration
-resistant state are numerous and have been subjected to extensive research in the past.
One possible incentive for the continuation of conventional ADT may lay in the assumption of a broader mode of therapy in the
castration
-resistant state. The mechanisms that lead to the
castration
-resistant state are numerous and have been subjected to extensive research in the past.
pjoshea13
in
Advanced Prostate Cancer
7 years ago
Body composition & Docetaxel (Taxotere)
This is a loss of muscle mass, which of course happens with
castration
. Resistance exercise can counter it. Sarcopenia was not associated with survival, but "sarcopenia and low {muscle attenuation} are associated with neutropenia".
This is a loss of muscle mass, which of course happens with
castration
. Resistance exercise can counter it. Sarcopenia was not associated with survival, but "sarcopenia and low {muscle attenuation} are associated with neutropenia".
pjoshea13
in
Advanced Prostate Cancer
7 years ago
LATITUDE - Zytiga & ADT - NEJM Paper
[Epub ahead of print] Abiraterone plus Prednisone in Metastatic,
Castration
-Sensitive Prostate Cancer.
[Epub ahead of print] Abiraterone plus Prednisone in Metastatic,
Castration
-Sensitive Prostate Cancer.
pjoshea13
in
Advanced Prostate Cancer
7 years ago
Foods/Supplements-Vitamins: Ketogenic Diet
mice was thought to be from decreased signaling of the insulin/ insulin-like growth factor (IGF) axis, a pathway integral in the progression of PCa" "While these dietary changes appear to be promising for slowing tumor growth, the best established therapy for stunting PCa involves chemical or surgical
castration
mice was thought to be from decreased signaling of the insulin/ insulin-like growth factor (IGF) axis, a pathway integral in the progression of PCa" "While these dietary changes appear to be promising for slowing tumor growth, the best established therapy for stunting PCa involves chemical or surgical
castration
pjoshea13
in
Advanced Prostate Cancer
7 years ago
CRPC & Prednisolone or Dexamethasone. Neutrophil to Lymphocyte Ratio [NLR].
Prednisone/Prednisolone & Dexamethasone are corticosteroids - steroid hormones that "have been used in the therapy for
castration
-resistant prostate cancer (CRPC) for decades, both as monotherapy and in combination with additional agents." [2] "... prednisone is distinctly different from prednisolone
Prednisone/Prednisolone & Dexamethasone are corticosteroids - steroid hormones that "have been used in the therapy for
castration
-resistant prostate cancer (CRPC) for decades, both as monotherapy and in combination with additional agents." [2] "... prednisone is distinctly different from prednisolone
pjoshea13
in
Advanced Prostate Cancer
7 years ago
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