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News that worried us and studies that gave us hope (04/2022).
This is the information that gave us hope while my father was alive and has given hope to many since then (March 2012). 1. News that worried us. In the coming decades the number of Parkinson's disease patients is feared to increase very worryingly, to double by 2030 (Dorsey 2007) and even to triple
This is the information that gave us hope while my father was alive and has given hope to many since then (March 2012). 1. News that worried us. In the coming decades the number of Parkinson's disease patients is feared to increase very worryingly, to double by 2030 (Dorsey 2007) and even to triple
parkinsonshereandnow
in
Cure Parkinson's
2 years ago
UM-Palmitoylethanolamide can slow down Parkinson's disease 2017
I know, it is only 19 days since I posted on this topic: https://healthunlocked.com/cure-parkinsons/posts/147737298/palmitoylethanolamide-luteolin-kind-of-interesting But sometimes I bury the lead. I normally stay away from eurekalert.org (I'm not sure why. I guess I thought it was some advertising site
I know, it is only 19 days since I posted on this topic: https://healthunlocked.com/cure-parkinsons/posts/147737298/palmitoylethanolamide-luteolin-kind-of-interesting But sometimes I bury the lead. I normally stay away from eurekalert.org (I'm not sure why. I guess I thought it was some advertising site
Bolt_Upright
in
Cure Parkinson's
2 years ago
INBRAIN PHARMA: direct injection of dopamine into the brain
Injecting dopamine directly into the brain using a small internal pump is what Lille researchers have succeeded in limiting the adverse effects of conventional drugs linked to Parkinson's disease. The InBrain Pharma team is pleased to see its therapeutic solution - backed by very promising initial safety
Injecting dopamine directly into the brain using a small internal pump is what Lille researchers have succeeded in limiting the adverse effects of conventional drugs linked to Parkinson's disease. The InBrain Pharma team is pleased to see its therapeutic solution - backed by very promising initial safety
Hidden
in
Cure Parkinson's
2 years ago
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Oral berberine improves brain dopa/dopamine levels to ameliorate Parkinson’s disease by regulating gut microbiota
EDIT March 17, 2024:
Today somebody shared a link to a two year old post of mine about a report on Berberine being neurotoxic and taking it off of my stack. Within a few months I found other information on Berberine and, using my High School educated brain, decided that Berberine definitely needed
EDIT March 17, 2024:
Today somebody shared a link to a two year old post of mine about a report on Berberine being neurotoxic and taking it off of my stack. Within a few months I found other information on Berberine and, using my High School educated brain, decided that Berberine definitely needed
Bolt_Upright
in
Cure Parkinson's
2 years ago
This is very interesting
https://neurosciencenews.com/parkinsons-probiotic-20287/amp/ Probiotics to deliver l-dopa
https://neurosciencenews.com/parkinsons-probiotic-20287/amp/ Probiotics to deliver l-dopa
Ponieboy
in
Cure Parkinson's
3 years ago
Harnessing Probiotics to Deliver Parkinson’s Disease Treatment
Summary: A newly developed probiotic bacteria that can synthesize the dopamine precursor L-DOPA is safe, well-tolerated, and eliminates the side effects associated with L-DOPA use for Parkinson’s Researchers have engineered probiotic bacteria that can synthesize the dopamine precursor L-DOPA, a powerful
Summary: A newly developed probiotic bacteria that can synthesize the dopamine precursor L-DOPA is safe, well-tolerated, and eliminates the side effects associated with L-DOPA use for Parkinson’s Researchers have engineered probiotic bacteria that can synthesize the dopamine precursor L-DOPA, a powerful
jimcaster
in
Cure Parkinson's
3 years ago
Encouraging Stem Cell Trial Results
Top-line Parkinson's Disease Clinical Trial Results ISCO successfully completed the treatment phase of its dose escalating phase 1 clinical trial (ClinicalTrials.gov Identifier: NCT02452723) evaluating the safety, tolerability, and preliminary efficacy of its lead candidate, ISC-hpNSC® for the treatment
Top-line Parkinson's Disease Clinical Trial Results ISCO successfully completed the treatment phase of its dose escalating phase 1 clinical trial (ClinicalTrials.gov Identifier: NCT02452723) evaluating the safety, tolerability, and preliminary efficacy of its lead candidate, ISC-hpNSC® for the treatment
jimcaster
in
Cure Parkinson's
3 years ago
How to estimate the short-term benefit of carbidopa/levodopa
One of the common symptoms of PD is bradykinesia (slow movements). You might, for instance, type more slowly when you are "Off", rather than when you are "0n". A good measure for bradykinesia is the side-to-side tap test. In this test you sit at a computer keyboard and, using just the index finger of
One of the common symptoms of PD is bradykinesia (slow movements). You might, for instance, type more slowly when you are "Off", rather than when you are "0n". A good measure for bradykinesia is the side-to-side tap test. In this test you sit at a computer keyboard and, using just the index finger of
johntPM
in
Cure Parkinson's
3 years ago
Dehydroascorbic acid: Could orange juice oxidised in the fridge overnight be an important weapon against Parkinson's?
Dehydroascorbic acid is the oxidised and reversible form of ascorbic acid or vitamin C. It can protect the brain and reduce stroke mortality, due to its ability to cross the blood-brain barrier, whereas vitamin C or ascorbic acid cannot easily do so. In one study it was proposed as a possible treatment
Dehydroascorbic acid is the oxidised and reversible form of ascorbic acid or vitamin C. It can protect the brain and reduce stroke mortality, due to its ability to cross the blood-brain barrier, whereas vitamin C or ascorbic acid cannot easily do so. In one study it was proposed as a possible treatment
parkinsonshereandnow
in
Cure Parkinson's
3 years ago
Palmitoylethanolamide Honokiol Combination
(I will be doing this once my palmitoylethanolamide arrives) "Chronic pain : two tested natural compounds may break pain cycle : could they be useful in neurodegenerative disease? 2022 https://cme30.eu/chronic-pain-two-tested-natural-compounds-may-break-pain-cycle-could-they-be-useful-in-neurodegenerative-disease
(I will be doing this once my palmitoylethanolamide arrives) "Chronic pain : two tested natural compounds may break pain cycle : could they be useful in neurodegenerative disease? 2022 https://cme30.eu/chronic-pain-two-tested-natural-compounds-may-break-pain-cycle-could-they-be-useful-in-neurodegenerative-disease
Bolt_Upright
in
Cure Parkinson's
3 years ago
The end of Parkinson's as we know it today. From the Levodopa era to the "transformative" information era.
1. History and Time. As a vocational and professional historian, I have contemplated the world of Parkinson's for many years. The changes over time in the way the disease is viewed, the possible treatments and everything that makes up the world of Parkinson's (multinationals, neurologists, associations
1. History and Time. As a vocational and professional historian, I have contemplated the world of Parkinson's for many years. The changes over time in the way the disease is viewed, the possible treatments and everything that makes up the world of Parkinson's (multinationals, neurologists, associations
parkinsonshereandnow
in
Cure Parkinson's
3 years ago
How I went from 13 to 4 a day (Carbidopa 25/Levodopa 100)?
Also, it is widely accepted that there is a multitude of side effects of
Carbidopa
/
Levodopa
, one being dyskinesia.
Also, it is widely accepted that there is a multitude of side effects of
Carbidopa
/
Levodopa
, one being dyskinesia.
Gcf51
in
Cure Parkinson's
3 years ago
PwP, Glaucoma and Citicoline
Previously I posted about the usefulness of Citicoline for memory issues here: https://healthunlocked.com/cure-parkinsons/posts/146670603/part-2-reversing-memory-deficits-and-senior-moments-in-a-78-year-old Here is a review that gives a good idea of the benefits of citicoline in PwP: https://www.researchgate.net
Previously I posted about the usefulness of Citicoline for memory issues here: https://healthunlocked.com/cure-parkinsons/posts/146670603/part-2-reversing-memory-deficits-and-senior-moments-in-a-78-year-old Here is a review that gives a good idea of the benefits of citicoline in PwP: https://www.researchgate.net
chartist
in
Cure Parkinson's
3 years ago
Palmitoylethanolamide - Luteolin: Kind of Interesting
So I was bouncing around and found this article: Palmitoylethanolamide/Luteolin as Adjuvant Therapy to Improve an Unusual Case of Camptocormia in a Patient with Parkinson’s Disease: A Case Report 2021 https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC8794485/ This is a single case report about a fairly
So I was bouncing around and found this article: Palmitoylethanolamide/Luteolin as Adjuvant Therapy to Improve an Unusual Case of Camptocormia in a Patient with Parkinson’s Disease: A Case Report 2021 https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC8794485/ This is a single case report about a fairly
Bolt_Upright
in
Cure Parkinson's
3 years ago
Cannabis and its derivatives for the use of motor symptoms in Parkinson’s disease: a systematic review and meta-analysis
Cannabis and its derivatives for the use of motor symptoms in Parkinson’s disease: a systematic review and meta-analysis 2021 https://journals.sagepub.com/doi/full/10.1177/17562864211018561 "Results: Fifteen studies, including six RCTs, were analyzed. Of these, 12/15 (80%) mention concomitant treatment
Cannabis and its derivatives for the use of motor symptoms in Parkinson’s disease: a systematic review and meta-analysis 2021 https://journals.sagepub.com/doi/full/10.1177/17562864211018561 "Results: Fifteen studies, including six RCTs, were analyzed. Of these, 12/15 (80%) mention concomitant treatment
Bolt_Upright
in
Cure Parkinson's
3 years ago
From regenerative strategies to pharmacological approaches: can we fine-tune treatment for Parkinson's disease? (Starting my NAC again!)2022
This new article covers combining Stem Cells Secretome (SCS) and NAC to treat PD. From regenerative strategies to pharmacological approaches: can we fine-tune treatment for Parkinson's disease? https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC8552835/ "Abstract Parkinson's disease is the second most
This new article covers combining Stem Cells Secretome (SCS) and NAC to treat PD. From regenerative strategies to pharmacological approaches: can we fine-tune treatment for Parkinson's disease? https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC8552835/ "Abstract Parkinson's disease is the second most
Bolt_Upright
in
Cure Parkinson's
3 years ago
Third dose of levodopa on the day generally fails to work.
Hi. Im on a combination of madopar 3 tablets of 50/12.5 mg and mucuna pruriens. 325mg exttract. I alternate them one dose madopar inthe morning, 9.30, then mucuna at 1.30, then madopar at 6.30pm and mucuna at 10.30 pm before sleep. While the first two doses work perfectly ( tremor, and central pain controlled
Hi. Im on a combination of madopar 3 tablets of 50/12.5 mg and mucuna pruriens. 325mg exttract. I alternate them one dose madopar inthe morning, 9.30, then mucuna at 1.30, then madopar at 6.30pm and mucuna at 10.30 pm before sleep. While the first two doses work perfectly ( tremor, and central pain controlled
HekateMoon
in
Cure Parkinson's
3 years ago
The Neuroendocrine Connection
Adrenal hormones, sex hormones, and neurotransmitters are functionally interrelated. Changes in sex hormones and adrenal hormones can lead to neurotransmitter imbalances. In turn, neurotransmitter imbalances can affect hormone function. The following tests are recommended to establish your baseline.
Adrenal hormones, sex hormones, and neurotransmitters are functionally interrelated. Changes in sex hormones and adrenal hormones can lead to neurotransmitter imbalances. In turn, neurotransmitter imbalances can affect hormone function. The following tests are recommended to establish your baseline.
SilentEchoes
in
Cure Parkinson's
3 years ago
BioVie announces treatment of 1st patient in Phase 2 clinical trial of NE3107,ERK inhibitor that selectively inhibits neuroinflammation
Participants will be treated with
carbidopa
/
levodopa
and NE3107 or placebo. Forty patients with a defined PD medication “off state” will be randomized 1:1 placebo to: active NE3107 20 mg twice daily for 28 days.
Participants will be treated with
carbidopa
/
levodopa
and NE3107 or placebo. Forty patients with a defined PD medication “off state” will be randomized 1:1 placebo to: active NE3107 20 mg twice daily for 28 days.
Hidden
in
Cure Parkinson's
3 years ago
Titrating down on Sinemet experience
I wanted to post my experience titrating down in case it helped someone else who was trying to do the same thing. I was originally prescribed 25/100 3 tablets per day (sinemet) 2 years ago. RH tremor was my only major symptom at that time. After 2 months of nausea, my body got used to the drug and
I wanted to post my experience titrating down in case it helped someone else who was trying to do the same thing. I was originally prescribed 25/100 3 tablets per day (sinemet) 2 years ago. RH tremor was my only major symptom at that time. After 2 months of nausea, my body got used to the drug and
Missy0202
in
Cure Parkinson's
3 years ago
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