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Cabazitaxel
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Use of Rx drugs and botanical compounds to prevent chemo drug-resistance with Docetaxel.
Recently published data that showed that a second taxane (
cabazitaxel
) extends survival after progression on docetaxel was a significant step forward, but also highlighted the need to overcome taxane resistance in prostate cancer.
Recently published data that showed that a second taxane (
cabazitaxel
) extends survival after progression on docetaxel was a significant step forward, but also highlighted the need to overcome taxane resistance in prostate cancer.
chillpill7
in
Advanced Prostate Cancer
5 years ago
35 Days Of Taking Zytiga With Food
Zytiga/Food) ALKALINE PHOSPHATASE 154 ALT 18 AST 19 BILIRUBIN, TOTAL 1.4 GLUCOSE 165 PSA 19.6 May 15 2019 (35 days taking Zytiga/Food) ALKALINE PHOSPHATASE 145 ALT 13 AST 17 BILIRUBIN, TOTAL 1.1 GLUCOSE 112 PSA 33.4 As a note my MO is working on getting me into a trial of Olaparib,
Cabazitaxel
Zytiga/Food) ALKALINE PHOSPHATASE 154 ALT 18 AST 19 BILIRUBIN, TOTAL 1.4 GLUCOSE 165 PSA 19.6 May 15 2019 (35 days taking Zytiga/Food) ALKALINE PHOSPHATASE 145 ALT 13 AST 17 BILIRUBIN, TOTAL 1.1 GLUCOSE 112 PSA 33.4 As a note my MO is working on getting me into a trial of Olaparib,
Cabazitaxel
SsamO
in
Advanced Prostate Cancer
5 years ago
Where to get Lu177 PSMA therapy in Australia
In Australia there is a trial comparing Lu177 therapy versus
Cabazitaxel
. Here are two slides about this trial. I post this, because the mentioned clinics will probably offer the treatment also outside of this trial and have a PSMA PET/CT available for diagnostics.
In Australia there is a trial comparing Lu177 therapy versus
Cabazitaxel
. Here are two slides about this trial. I post this, because the mentioned clinics will probably offer the treatment also outside of this trial and have a PSMA PET/CT available for diagnostics.
GP24
in
Advanced Prostate Cancer
5 years ago
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Things worse
The doctor at mdandersen wants to do “ randomized phase 2 Study of olapatrib maintenance following
cabazitaxel
-carboplatin induction chemo therapy I men with aggressive variant prostate cancer. (Avpc) 2017-0133 Can anyone give me opinion or advise.
The doctor at mdandersen wants to do “ randomized phase 2 Study of olapatrib maintenance following
cabazitaxel
-carboplatin induction chemo therapy I men with aggressive variant prostate cancer. (Avpc) 2017-0133 Can anyone give me opinion or advise.
elainea53
in
Advanced Prostate Cancer
5 years ago
AR-V7 and Circulating Tumor Cell DNA Testing - Availability and Use
The detection of AR-V7 in the nucleus is associated with a reduced response to abiraterone and enzalutamide and better response to chemotherapy such as docetaxel and
cabazitaxel
.
The detection of AR-V7 in the nucleus is associated with a reduced response to abiraterone and enzalutamide and better response to chemotherapy such as docetaxel and
cabazitaxel
.
PhilipSZacarias
in
Advanced Prostate Cancer
5 years ago
3 Years Post Diagnosis.
After that failed to slow the progression, I was moved onto
cabazitaxel
. After even more evidence of progression, I was taken off all medication, with the exception of Zoladex 3-mthly implants. My oncologist told me there was nothing further to offer me.
After that failed to slow the progression, I was moved onto
cabazitaxel
. After even more evidence of progression, I was taken off all medication, with the exception of Zoladex 3-mthly implants. My oncologist told me there was nothing further to offer me.
paulofaus
in
Advanced Prostate Cancer
5 years ago
Integrating Novel Targets and Precision Medicine Into Prostate Cancer Care—Part 1: The Non-Androgen–Targetable Pathways in Castration-Resist
of
cabazitaxel
in 2010.
of
cabazitaxel
in 2010.
JLS1
in
Advanced Prostate Cancer
5 years ago
HPN 424 (Harpoon) Trial
I am resistant to Xtandi and chemo (taxotere and
cabazitaxel
) no longer working. Looking for that last hope.
I am resistant to Xtandi and chemo (taxotere and
cabazitaxel
) no longer working. Looking for that last hope.
Hidden
in
Advanced Prostate Cancer
5 years ago
My Story
November 2018 I started
cabazitaxel
chemo but halfway through the cycles, the PET scan showed new bony disease so it was abandoned. ironically the cancer in my prostate is completely dormant. I can have radium 223 but would prefer to try Lutetium -177 first.
November 2018 I started
cabazitaxel
chemo but halfway through the cycles, the PET scan showed new bony disease so it was abandoned. ironically the cancer in my prostate is completely dormant. I can have radium 223 but would prefer to try Lutetium -177 first.
ellyras
in
Advanced Prostate Cancer
5 years ago
Severe weakness and imbalance
My dad has advanced prostate cancer with current psa of 37 and metastasis to bones .he was diagnosed on May 10th 2018, he didn’t respond well and the treatment changed to
Cabazitaxel
and Abiraterone.... the treatment stopped due to its severe side effects.Its now 3 months that he hasn’t under any treatment
My dad has advanced prostate cancer with current psa of 37 and metastasis to bones .he was diagnosed on May 10th 2018, he didn’t respond well and the treatment changed to
Cabazitaxel
and Abiraterone.... the treatment stopped due to its severe side effects.Its now 3 months that he hasn’t under any treatment
Annie1373
in
Advanced Prostate Cancer
5 years ago
Viewer Discretion Advised
Currently my MO is searching for a suitable Trial Study, if none are found he is suggesting
Cabazitaxel
/Carboplatin chemo or Xtandi/Xofigo combos. I welcome any thoughts or suggestions regarding treatments going forward. Best to everyone.
Currently my MO is searching for a suitable Trial Study, if none are found he is suggesting
Cabazitaxel
/Carboplatin chemo or Xtandi/Xofigo combos. I welcome any thoughts or suggestions regarding treatments going forward. Best to everyone.
SsamO
in
Advanced Prostate Cancer
5 years ago
We should admit it
I think it’s end of our journey,Dad diagnosised on May13th with metastasis.Nothing worked on him Docetaxcel,Abiraterone and
cabazitaxel
...Now he states that he has pain his chest ...I think there’s no hope ..We should admit it
I think it’s end of our journey,Dad diagnosised on May13th with metastasis.Nothing worked on him Docetaxcel,Abiraterone and
cabazitaxel
...Now he states that he has pain his chest ...I think there’s no hope ..We should admit it
Annie1373
in
Advanced Prostate Cancer
5 years ago
Drug Effective in 80% of Men With BRCA-mutant Prostate Cancer
All had progressed on ADT; 99% were post-docetaxel, 90% post-abiraterone/enzalutamide, 38% post-
cabazitaxel
. The overall RR was 54% (95%CI 39-69%, meeting threshold for primary endpoint) in the 400mg cohort and 37% (95%CI 23-53%) in the 300mg cohort.
All had progressed on ADT; 99% were post-docetaxel, 90% post-abiraterone/enzalutamide, 38% post-
cabazitaxel
. The overall RR was 54% (95%CI 39-69%, meeting threshold for primary endpoint) in the 400mg cohort and 37% (95%CI 23-53%) in the 300mg cohort.
pjoshea13
in
Advanced Prostate Cancer
5 years ago
Treatment failure
Cabazitaxel
and Abiraterone has made him so weak he can’t eat at all for 2 weeks and he has weight loss ,His oncologist said disappointing things and I all I can do is crying
Cabazitaxel
and Abiraterone has made him so weak he can’t eat at all for 2 weeks and he has weight loss ,His oncologist said disappointing things and I all I can do is crying
Annie1373
in
Advanced Prostate Cancer
5 years ago
Cabazitaxel/Carboplatin w/4.4 PSA zenith
What about requesting it after 3.5 years on Lupron, 1 on Casodex and 2 months on Xtandi (rough time estimates) w/a nadir of .92/peak of 4.2 PSA? Am I overboard? Nous Defions Crabcrusher
What about requesting it after 3.5 years on Lupron, 1 on Casodex and 2 months on Xtandi (rough time estimates) w/a nadir of .92/peak of 4.2 PSA? Am I overboard? Nous Defions Crabcrusher
Crabcrushe
in
Advanced Prostate Cancer
5 years ago
cabazitaxel+carboplatin
Anyone taking this combo?
Anyone taking this combo?
MontyB
in
Advanced Prostate Cancer
5 years ago
Looking for peoples experience of Radium 233 and Cabazitaxel.
Next step likely to be either Radium 233 or
Cabazitaxel
(Jevtana). There was mention of a trial called Lutetium but that does not open for a few months and is randomised. So just looking to hear peoples experience of either Radium 233 or
Cabazitaxel
to help with the decision making.
Next step likely to be either Radium 233 or
Cabazitaxel
(Jevtana). There was mention of a trial called Lutetium but that does not open for a few months and is randomised. So just looking to hear peoples experience of either Radium 233 or
Cabazitaxel
to help with the decision making.
Teddysdad
in
Advanced Prostate Cancer
6 years ago
Cabazitaxel, the Androgen Receptor [AR] & Heat Shock Proteins [HSPs]
Since
cabazitaxel
has also been demonstrated to inhibit androgen receptor (AR) functionality, AR and AR-associated heat shock protein (HSP) expressions in the presence of
cabazitaxel
were characterized.
Since
cabazitaxel
has also been demonstrated to inhibit androgen receptor (AR) functionality, AR and AR-associated heat shock protein (HSP) expressions in the presence of
cabazitaxel
were characterized.
pjoshea13
in
Advanced Prostate Cancer
6 years ago
CRPC with Complications.. Do not know what to do now ?
I am so stressed and sad as well, thinking of every possible way that can give us some hope and I am afraid that he won't make it and unfortunately no Chemotherapy can fits for him anymore ( he was not on
Cabazitaxel
) . Do you have any suggestions ? Any herbal medicine ?
I am so stressed and sad as well, thinking of every possible way that can give us some hope and I am afraid that he won't make it and unfortunately no Chemotherapy can fits for him anymore ( he was not on
Cabazitaxel
) . Do you have any suggestions ? Any herbal medicine ?
Cladius
in
Advanced Prostate Cancer
6 years ago
Metastasis-Free Survival in Prostate Cancer: Faster Drug Approvals, Better Drugs?
Since then, the FDA has approved four other agents (enzalutamide,
cabazitaxel
, radium-223, and sipuleucel-T) on the basis of an OS benefit in metastatic prostate cancer. Promising data also exist for other investigational agents in progressive metastatic CRPC.
Since then, the FDA has approved four other agents (enzalutamide,
cabazitaxel
, radium-223, and sipuleucel-T) on the basis of an OS benefit in metastatic prostate cancer. Promising data also exist for other investigational agents in progressive metastatic CRPC.
pjoshea13
in
Advanced Prostate Cancer
6 years ago
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