Things worse

[elainea53]

My husbands pc has gotten worse.

The doctor at mdandersen wants to do “ randomized phase 2

Study of olapatrib maintenance following cabazitaxel-carboplatin induction chemo therapy I men with aggressive variant prostate cancer. (Avpc) 2017-0133

Can anyone give me opinion or advise.

[ctarleton]

In case you may not have seen it, here's the full listing for the Clinical Trial you mentioned.

clinicaltrials.gov/ct2/show...

Here's some info that contains some previous experiences on Jevtana (Cabazitaxel).

accessdata.fda.gov/drugsatf...

Here's some info that contains some previous experiences on Carboplatin (Paraplatin).

(Been approved since 1989. Many generic names by now.)

Overview:

hemonc.org/wiki/Carboplatin...

chemocare.com/chemotherapy/...

In Ovarian cancer:

hemonc.org/w/images/6/65/Ca...

Here's some info that contains some previous experiences on Lynparza (Olaparib).

accessdata.fda.gov/drugsatf...

Good Luck as you continue to decide about this Clinical Trial or other treatment options.

"Eyes wide open".

Charles

[elainea53 in reply to ctarleton]

thanks very helpful.

[noirhole]

Clinical trials give you much latitude. You can quit at any time and you ever very good monitoring.

[elainea53]

thanks.

he has jacks mutation.

[scarlino]

Yes I’ve done a number of clinical trials at MD Anderson. The great thing is they do very aggressive monitoring schedules so they keep on top of your disease during the trial. Ask the doctor why he/she thinks this might be appropriate/beneficial then decide based on that.

[elainea53]

Than you I would appreciate it

[Drcrunch]

You said genetic testing was negative, so why are they pushing for olaparib trial

[elainea53]

He has the jak mutations.

[Stegosaurus37]

Olaparib is a PARP inhibitor. Common side effects are nausea and vomiting. Also constipation - which can be severe.

[Litlerny]

What gene mutation does your husband have? As far as I know, Olaparib (brand name Lynparza) has been FDA approved for breast and ovarian cancers, but does not yet have final FDA approval for use in prostate cancer. However, based on the interim results of a couple of ongoing clinical trials it has been given “breakthrough” FDA approval for CRPC PCa patients who have already undergone chemotherapy and ADT, and who have BRCA 1-2 or ATM gene mutations. The benefits have been particularly good for those with the BRCA mutations, not so much with ATM mutations.

[elainea53]

Jax mutation

He will get regular chemo 2 and then the trial