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clinical trial: ATR inhibitor for ATM mutated solid tumors
in vivo and in vitro studies suggest that ATR inhibitors work better than PARP inhibitors for people with ATM gene mutations…but together they may work even better I hope to find more data about this clinical trial https://www.biospace.com/article/releases/aprea-therapeutics-announces-dosing-of-first-patient-in-phase
in vivo and in vitro studies suggest that ATR inhibitors work better than PARP inhibitors for people with ATM gene mutations…but together they may work even better I hope to find more data about this clinical trial https://www.biospace.com/article/releases/aprea-therapeutics-announces-dosing-of-first-patient-in-phase
Maxone73
in
Advanced Prostate Cancer
4 months ago
Heart Issues post Ivor Lewis
Hi, wondering if any of you that have had the Ivor Lewis surgery have had heart issues post surgery? At 3 years post surgery I started having atrial fibralation. Now 5 years post surgery and the afib is worse but I also have Braychardia ( very low heart rate) Looks like I will need a cardiac ablation
Hi, wondering if any of you that have had the Ivor Lewis surgery have had heart issues post surgery? At 3 years post surgery I started having atrial fibralation. Now 5 years post surgery and the afib is worse but I also have Braychardia ( very low heart rate) Looks like I will need a cardiac ablation
Janashlin
in
Oesophageal & Gastric Cancer
4 months ago
Conflicting MRI vs PSMA scans
Well it appears that the radiologist who did my MRI was overly cautious. The report said I had a met on my left pelvis, one on my right pelvis, one on my sacrum, additional cancer in my prostate region and sclerotic foci in my pelvic region. Traumatic. We followed that up with a PSMA scan 10 days
Well it appears that the radiologist who did my MRI was overly cautious. The report said I had a met on my left pelvis, one on my right pelvis, one on my sacrum, additional cancer in my prostate region and sclerotic foci in my pelvic region. Traumatic. We followed that up with a PSMA scan 10 days
icanwintwice
in
Advanced Prostate Cancer
7 months ago
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lung ca and Crizotinib
hi I had been actually diagnosed with leimyosarcoma in calf muscle two years ago and successfully it was surgically removed and later no chemo was given. However in my scans there was a lung lesion that was there is scans but it was missed and left untreated till it reached stage 4. Now that I have been
hi I had been actually diagnosed with leimyosarcoma in calf muscle two years ago and successfully it was surgically removed and later no chemo was given. However in my scans there was a lung lesion that was there is scans but it was missed and left untreated till it reached stage 4. Now that I have been
Hassan786
in
Lung Cancer Support
4 months ago
Taste Issues and finger neuropathy on Xtandi( enzalutamide) ?
In order to participate in a clinical trial (FOR46 at UCSF) I had to switch from Nubeqa (darolutamide) to enzalutamide. Previously on abiraterone. Did really well on both medications. Now 4 months on enzalutamide and my 5th research infusion, I'm experiencing some side effects. Trying to determine
In order to participate in a clinical trial (FOR46 at UCSF) I had to switch from Nubeqa (darolutamide) to enzalutamide. Previously on abiraterone. Did really well on both medications. Now 4 months on enzalutamide and my 5th research infusion, I'm experiencing some side effects. Trying to determine
bandgeek
in
Advanced Prostate Cancer
4 months ago
Midlands Health and Wellbeing Day - Saturday 25 November
Hello everyone, Ovacome will be hosting a free Health and Wellbeing Day in Dudley for anyone who has been affected by ovarian cancer. Join us on Saturday 25 November from 10am to 4pm at the Village Hotel, Dudley. The day will provide an opportunity to meet others who have been diagnosed with ovarian
Hello everyone, Ovacome will be hosting a free Health and Wellbeing Day in Dudley for anyone who has been affected by ovarian cancer. Join us on Saturday 25 November from 10am to 4pm at the Village Hotel, Dudley. The day will provide an opportunity to meet others who have been diagnosed with ovarian
OvacomeSupport
My Ovacome Team
in
My Ovacome
7 months ago
New therapy (I hope I am not repeating myself)
https://www.urologytimes.com/view/antibody-drug-conjugate-plus-docetaxel-shows-promise-in-metastatic-prostate-cancer The novel antibody-drug conjugate PDS0301 (M9241) in combination with docetaxel demonstrated promising safety and immune response signals in patients with metastatic castration-sensitive
https://www.urologytimes.com/view/antibody-drug-conjugate-plus-docetaxel-shows-promise-in-metastatic-prostate-cancer The novel antibody-drug conjugate PDS0301 (M9241) in combination with docetaxel demonstrated promising safety and immune response signals in patients with metastatic castration-sensitive
Maxone73
in
Advanced Prostate Cancer
7 months ago
my cancer comic…
I’m a graphic designer who has done autobiographical comics for around 16 years, mostly about medical stuff (detached retina, thyroid surgery, a bad fall, gallbladder surgery…). Late last year I was diagnosed with prostate cancer. Just my prostate and some pelvic lymph nodes at this point, and awaiting
I’m a graphic designer who has done autobiographical comics for around 16 years, mostly about medical stuff (detached retina, thyroid surgery, a bad fall, gallbladder surgery…). Late last year I was diagnosed with prostate cancer. Just my prostate and some pelvic lymph nodes at this point, and awaiting
Jpburns
in
Advanced Prostate Cancer
4 months ago
Go-forward Treatment Plan
First of all, I've been an avid reader of this forum over the past 2 years, and wanted to express my gratitude towards the amount of knowledge everyone has been sharing on this site. My father (62 y.o., very healthy) was diagnosed with aggressive PCa (Gleason 9, PSA 58) in Sep 2021, and underwent RALP
First of all, I've been an avid reader of this forum over the past 2 years, and wanted to express my gratitude towards the amount of knowledge everyone has been sharing on this site. My father (62 y.o., very healthy) was diagnosed with aggressive PCa (Gleason 9, PSA 58) in Sep 2021, and underwent RALP
sixmongoos
in
Advanced Prostate Cancer
7 months ago
copd sucks
Good morning everyone My copd as got so bad over the past 4 weeks and to top that off I have a bad chest infection and the flu , The hospital gave me a nebuliser to take home and I can use it two times aday morning and evening and it’s working so much better than my pumps and I’m also on prednisone
Good morning everyone My copd as got so bad over the past 4 weeks and to top that off I have a bad chest infection and the flu , The hospital gave me a nebuliser to take home and I can use it two times aday morning and evening and it’s working so much better than my pumps and I’m also on prednisone
Sweetapple51
in
Lung Conditions Community Forum
4 months ago
Update and advice needed x
Thank you all for your lovely comments. CT scan result shows a small area on the outside of the bowel which needs further investigation. Really shocked to hear this! After the procedure had been told cancer removed. Has anybody had a similar experience? Oncologist unable to say if it’s ovarian/bowel
Thank you all for your lovely comments. CT scan result shows a small area on the outside of the bowel which needs further investigation. Really shocked to hear this! After the procedure had been told cancer removed. Has anybody had a similar experience? Oncologist unable to say if it’s ovarian/bowel
ORGM
in
My Ovacome
4 months ago
any tips for Caelyx side effects (pdrh
I’m stage 3c High grade serous I had debunking surgery an started my first attempt at chemo in September I’m allergic to paclitaxel so they are going to try Caelyx (pegylated liposomal dioxyrubicin). Alongside the carboplatin I’ve read a lot about side effects has anyone gif any tips for managing
I’m stage 3c High grade serous I had debunking surgery an started my first attempt at chemo in September I’m allergic to paclitaxel so they are going to try Caelyx (pegylated liposomal dioxyrubicin). Alongside the carboplatin I’ve read a lot about side effects has anyone gif any tips for managing
Beatbigc
in
My Ovacome
7 months ago
Bladder Cancer, biopsy and operation.
I all happened so quickly,next week pre-op discussion and operation on Friday. I would like to receive response from people who have had urinary bladder biopsy operation. Thanka a lot in advance.
I all happened so quickly,next week pre-op discussion and operation on Friday. I would like to receive response from people who have had urinary bladder biopsy operation. Thanka a lot in advance.
sandybrown
in
Lung Conditions Community Forum
4 months ago
Who has ESR1 how are you doing
I just developed the ESR1 mutation and went on Faslodex and switched to Kisquali. I was wondering if anyone has this mutation and how your meds working. I’m only looking to hear about ESR1 stories and if it impacted your treatment or progression and how you are doing. If you do not have the mutation
I just developed the ESR1 mutation and went on Faslodex and switched to Kisquali. I was wondering if anyone has this mutation and how your meds working. I’m only looking to hear about ESR1 stories and if it impacted your treatment or progression and how you are doing. If you do not have the mutation
DDIL1
in
SHARE Metastatic Breast Cancer
1 year ago
Abdominal and decending aorta aneurysms
Back in June 2023 I had a PET Scan. The results were negative, no matastisim, no other findings except divertculosis which I have had for years.Early January 2024, I had another PET Scan. No matastisism was found but, this time they found an abdominal Aorta Aneurysm 3.5 cm and an the makings of a decending
Back in June 2023 I had a PET Scan. The results were negative, no matastisim, no other findings except divertculosis which I have had for years.Early January 2024, I had another PET Scan. No matastisism was found but, this time they found an abdominal Aorta Aneurysm 3.5 cm and an the makings of a decending
woppaginny
in
Advanced Prostate Cancer
4 months ago
Leo 2327
Hi to all the ladies on this journey I am 3c ovarian cancer since May 2022 had 8 lots of chemo and debulking surgery and stoma then been on avastin for over a year last one next Friday and also take olaparib I am NED at the moment but I am suffering realy bad with hot sweats and tiredness is anyone else
Hi to all the ladies on this journey I am 3c ovarian cancer since May 2022 had 8 lots of chemo and debulking surgery and stoma then been on avastin for over a year last one next Friday and also take olaparib I am NED at the moment but I am suffering realy bad with hot sweats and tiredness is anyone else
Leo2327
in
My Ovacome
4 months ago
Delayed Lynparza (Olaparib)Reaction
I started Lynparza (Olaparib) on 5/19 (PSA 172). By 7/5 (+7 weeks ) my PSA was 222 and it was decided to discontinue the drug, get a port, and prepare for chemo. At the first chemo appt on 8/10 (+12 weeks), the blood test showed that my PSA had fallen to 194. The general literature says you evaluate
I started Lynparza (Olaparib) on 5/19 (PSA 172). By 7/5 (+7 weeks ) my PSA was 222 and it was decided to discontinue the drug, get a port, and prepare for chemo. At the first chemo appt on 8/10 (+12 weeks), the blood test showed that my PSA had fallen to 194. The general literature says you evaluate
OhioGuy2
in
Advanced Prostate Cancer
7 months ago
The Big C
Hello friends: After 3 and 1/2 years of GCA and prednisone, I think I’m pretty much free. I’m down to 1 mg every other day. As providence has dictated, I was just diagnosed with triple negative breast cancer, which is an aggressive and unforgiving cancer. My question regards my current Immune state
Hello friends: After 3 and 1/2 years of GCA and prednisone, I think I’m pretty much free. I’m down to 1 mg every other day. As providence has dictated, I was just diagnosed with triple negative breast cancer, which is an aggressive and unforgiving cancer. My question regards my current Immune state
Snerd
in
PMRGCAuk
4 months ago
And again news about clinical trials
Clinical trial tests creatine monohydrate and exercise to preserve muscle mass in prostate cancer
https://www.news-medical.net/news/20231011/Clinical-trial-tests-creatine-monohydrate-and-exercise-to-preserve-muscle-mass-in-prostate-cancer-patients.aspx (hint: been a natural bodybuilder from
Clinical trial tests creatine monohydrate and exercise to preserve muscle mass in prostate cancer
https://www.news-medical.net/news/20231011/Clinical-trial-tests-creatine-monohydrate-and-exercise-to-preserve-muscle-mass-in-prostate-cancer-patients.aspx (hint: been a natural bodybuilder from
Maxone73
in
Advanced Prostate Cancer
7 months ago
ED & zero libido
Three years on from diagnosis and nearly three year of no sexual function. A big loss between my wife and I thought we don’t really talk about it. My GP prescribes viagra but without the desire, little effect. Also given a pump but something makes me resistant to try it. Having said all this I have
Three years on from diagnosis and nearly three year of no sexual function. A big loss between my wife and I thought we don’t really talk about it. My GP prescribes viagra but without the desire, little effect. Also given a pump but something makes me resistant to try it. Having said all this I have
FortyWinks
in
Advanced Prostate Cancer
7 months ago
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