Experiences with

Biologic Therapy

“ABD-147 is a next-generation precision radiopharmaceutical biologic therapy designed to deliver Actinium-225 (225Ac) to solid tumors expressing DLL3, a protein found on the surface of neuroendocrine tumors, but rarely expressed on the surface of normal cells or tissues.”

I am now having biologic therapy for my asthma, specifically, tezspire once a month. So far I have had three injections. It's early days, I know, but my respiratory nurse has said that I should start to see an improvement in my symptoms after the third or fourth injection.

In phase 1/2 CaRe PC trial (NCT06056791) evaluating INKmune, a biologic therapy In its announcement on Monday, INmune said it successfully completed nine INKmune administrations in the outpatient setting within the first cohort in the trial.

The first patient with metastatic castration-resistant prostate cancer (mCRPC) has been dosed in the phase 1/2 CaRe PC trial (NCT06056791) evaluating INKmune, a biologic therapy https://www.targetedonc.com/view/first-patient-dosed-with-inkmune-therapy-in-phase-1-2-trial-for-mcrpc

Hi all, It’s been along time since I posted, I do read a lot of post which I find useful, but rarely have the time to post! I am currently off work due to change in meds again! I am currently on leflunamide as became intolerant to mtx it’s has been alot better, although swapping was a nightmare waiting

I just wanted to see if there was anyone out there similar to me and to see if anything worked. I'll try and briefly explain.... 4 years I've had it... Deep burning pain in my left bum cheek (si joint area) and throbbing burning all down my left side/leg. Basically sciatica. I can't sleep on my left

Hi It has been a long time since I have posted anything as have been severely ill with my asthma for the past two and a half years so that has taken all my time.To cut a long story short I am now on biological therapy which has so far changed my life!. Anyway I am now doing the dead slow method or whatever

”Orum has granted Vertex rights to conduct research using its TPD² approach to developing degrader-antibody conjugates (DACs), next-generation versions of antibody-drug conjugates (ADCs) which use antibodies to precisely deliver small molecule targeted protein degrader payloads to cancer cells and other

Hey All I hope everyone is well. This is my first time posting and I’m really hopeful someone will be able to advise me. I was diagnosed with lupus in Feb after just over 2 years of struggling with symptoms. Initially I was put on prednisolone and hydroxychloroquine until my bloods came back. My bloods

I'm currently on sertide and being switched over to symbicort. I'm not sure of the dosage etc as need to discuss further with gp. I'm a little concerned as been on seretide for years. When I get switched it triggers flares and I've already had loads of time of work. I work part time. I also think I'm

I was told a week ago to stop all my medication due to a chest infection and WBC being too low. I've been off my hydroxychloroquine and methotrexate for over a week now and weirdly my joints and swelling has been the best it's been for over 2 years. I feel perplexed has a 2 year flare just finished

I have been reading through all the posts on biological therapy.I have literally this week just heard that I qualify for Tezspire. The wait time is about 4 weeks. I am wondering who else is having this / had it and how they are getting on . Thank you.

Goal to reduce long-term glucocorticoids use to prevent side effects In both the U.S. and Europe, clinicians want to limit treatment with glucocorticoids — steroid hormones whose long-term use for autoimmune diseases is tied to serious side effects — among people with moderate to severe lupus

Hi after azaoprine caused liver cirrhosis, my consultant said I should start Adalimumab . I have had lots of various bloods taken including TB, HIV. Is this normal? 😳

I know it's likely I will need steroids again in the future without some type of biologic therapy. My eosinophil count has been a bit raised during flare-ups (0.3) but not enough it seems to warrant any further therapy.

I have been on methotrexate for 20 years for RA. I started at 10 mg. Went to 15mg fairly promptly and then 20mg last year. In general I had no side effects and good quality of life. Recently I started to have a lot of flares and my rheumatologist has recommended a biologic. He said I could try upping

A new research from Oslo University focuses on a new combination therapy for prostate cancer that uses a checkpoint inhibitor and an IRE1 blocker called MKC8866. The therapy works by blocking the IRE1 signaling pathway, which in turn reduces immunosuppressive effects in the tumor microenvironment and

Anyone seen this? This is what JSBMD is talking about https://pmc.ncbi.nlm.nih.gov/articles/PMC11083272/#sec6-ijms-25-04643 Conclusions TH inhibitors down-regulate DA levels and protect DA neurons, while DA receptor agonists function to activate post-synaptic DA receptors to alleviate PD symptoms

Can this be treated with targeted therapy such as Herceptin ( I am not aware of the presence of HER 2 ) but have been told that the surgical option would kill my husband who is 75 yrs old even though CT scan shows no spread . He has not had a PET scan.

Why: We know that leriglitazone/MIN-102 is effective at slowing the progression of AMN and greatly reducing the risk of cerebral involvement, but unless I'm missing something, it's not available to me here in the US currently. But its prodrug, pioglitazone, is, and given that leriglitazone is one of