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Therapies Targeted to Androgen Receptor SignalingAxis in Prostate Cancer: Progress, Challenges,and Hope - published December 2019
I was doing some research on ARL702H, which the Guardiant360 revealed for my husband. I think ARL702H is brought on from being on Zytiga + prednisone. - and this may be why switching from predisone to dexamethasone can help the Zytiga to continue working: Role of Androgen Receptor in Prostate Cancer
I was doing some research on ARL702H, which the Guardiant360 revealed for my husband. I think ARL702H is brought on from being on Zytiga + prednisone. - and this may be why switching from predisone to dexamethasone can help the Zytiga to continue working: Role of Androgen Receptor in Prostate Cancer
JLS1
in
Advanced Prostate Cancer
5 years ago
Severe joint pain while on Zytiga + dexamethasone + temazepam (for insomnia from dexamethasone) along with xofigo and xgeva
Has anyone else experienced odd severe joint pain that moves around, comes/goes and doesn't respond to OTC NSAIDs or Tylenol? Fast acting OXY 5s help, but can't take them due to possible serious interaction with the temazepam. After taxotere, then 1-1/2 years doing very well on Lynparza + Zytiga +
Has anyone else experienced odd severe joint pain that moves around, comes/goes and doesn't respond to OTC NSAIDs or Tylenol? Fast acting OXY 5s help, but can't take them due to possible serious interaction with the temazepam. After taxotere, then 1-1/2 years doing very well on Lynparza + Zytiga +
JLS1
in
Advanced Prostate Cancer
5 years ago
PSA increase after zytiga and steroid switch
Exactly 2 months ago, PSA was 2.26 switched from prednisone to dexamethasone. Today’s results are 2.68. In May psa was 0.1. Go to see oncologist next week. Not sure what to do next.
Exactly 2 months ago, PSA was 2.26 switched from prednisone to dexamethasone. Today’s results are 2.68. In May psa was 0.1. Go to see oncologist next week. Not sure what to do next.
Peterd110
in
Advanced Prostate Cancer
5 years ago
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When Meds stop working
I havent posted here before but started following because I have a close friend who is currently fighting the battle Diagnosed 11 years ago, had the surgery & more recently was on zytiga & prednesone Then it was switch to dexamethasone The side effects from both steroids although different were intolerable
I havent posted here before but started following because I have a close friend who is currently fighting the battle Diagnosed 11 years ago, had the surgery & more recently was on zytiga & prednesone Then it was switch to dexamethasone The side effects from both steroids although different were intolerable
concernedlady
in
Advanced Prostate Cancer
5 years ago
Warning - rant coming up
Met oncologist last Thurs. Good news- tumors in lungs shrinking, one behind eye NED but one at back of head growing. Due to continued isduescwith swelling agreed to refer me to Meuro MDT for decision on surgery/radiotherapy. Told I would hear early this week. Started chasing Tues morn. Countless phone
Met oncologist last Thurs. Good news- tumors in lungs shrinking, one behind eye NED but one at back of head growing. Due to continued isduescwith swelling agreed to refer me to Meuro MDT for decision on surgery/radiotherapy. Told I would hear early this week. Started chasing Tues morn. Countless phone
Aamar1
in
The Roy Castle Lung Cancer Foundation
5 years ago
Infiltrating duct carcinoma, stage III, age 55. Need help with understanding the case and cure
Hi, My Mother, age 55 has been detected with Duct Carcinoma on 10th Oct'19, had undergone surgery - Lt Side Quadractomy with axillary lymph nodes. The biopsy report states - Infiltrating Duct Carcinoma grade III. Size of tumor 1*0.6cm, Left AXLN-0.8,*0.6 cm, 4*2.8 cm necrotic lymph nodes in left axillary
Hi, My Mother, age 55 has been detected with Duct Carcinoma on 10th Oct'19, had undergone surgery - Lt Side Quadractomy with axillary lymph nodes. The biopsy report states - Infiltrating Duct Carcinoma grade III. Size of tumor 1*0.6cm, Left AXLN-0.8,*0.6 cm, 4*2.8 cm necrotic lymph nodes in left axillary
vinipathak
in
Breast Cancer India
5 years ago
Roller Coaster
My husband is 75, has been going to see his urologist every 6 months for 15 years he had put him on Flomax to help his symptoms. In May 2018 his PSA was OK 4.0 6 months later PSA level increased to 10.7 . Beginning of Dec he underwent surgery to remove bladder stones and the same time TURP was done
My husband is 75, has been going to see his urologist every 6 months for 15 years he had put him on Flomax to help his symptoms. In May 2018 his PSA was OK 4.0 6 months later PSA level increased to 10.7 . Beginning of Dec he underwent surgery to remove bladder stones and the same time TURP was done
formula27
in
Advanced Prostate Cancer
5 years ago
Can I do Provenge with Zytiga?
Been on zytiga for a little over a year. PSA rose from undetectable to 2.26 on oct 14. On oct 24 I had an appt with dr and he said to come back today ( oct 31) to discuss next treatment option ( Provenge, xofigo, Xtandi or PROSTAR trial using Xtandi) He did recheck my PSA on the oct 24 appt
Been on zytiga for a little over a year. PSA rose from undetectable to 2.26 on oct 14. On oct 24 I had an appt with dr and he said to come back today ( oct 31) to discuss next treatment option ( Provenge, xofigo, Xtandi or PROSTAR trial using Xtandi) He did recheck my PSA on the oct 24 appt
Peterd110
in
Advanced Prostate Cancer
5 years ago
Gabapentin & Low Platelets
Short story- I have been on Gabapentin for a few years I have been off it for about a week. I started bruising very easily so went to have my blood checked. My resting heart rate was 127 and my platelets count was 7 out of 150-400. The doctors are now checking me for everything (HIV, Leukemia, ITP
Short story- I have been on Gabapentin for a few years I have been off it for about a week. I started bruising very easily so went to have my blood checked. My resting heart rate was 127 and my platelets count was 7 out of 150-400. The doctors are now checking me for everything (HIV, Leukemia, ITP
JessicaD4
in
MPN Voice
5 years ago
Help with upcoming decisions
hello all, My husband will be heading to the oncologist next Tuesday after trying to rechallenge with Zytiga and dexamethasone after 5 rounds of docetaxel. he has been off chemo since June 26. since that time he has had several biopsies to get a sample to enter into the Vision trial, all of which were
hello all, My husband will be heading to the oncologist next Tuesday after trying to rechallenge with Zytiga and dexamethasone after 5 rounds of docetaxel. he has been off chemo since June 26. since that time he has had several biopsies to get a sample to enter into the Vision trial, all of which were
Dalipup
in
Advanced Prostate Cancer
5 years ago
Treating Itp with Herbal Supplements
Hi! I'm a newbie here! I came aboard to find a natural way to treat Itp. Since Prednisone isn't cutting it. Dexamethasone and Eltrombopag also didn't take. The Doctor's want to try rituximab next and I'm a little bit leary of that one. Then of course, if that doesn't work, they'll want to take my spleen
Hi! I'm a newbie here! I came aboard to find a natural way to treat Itp. Since Prednisone isn't cutting it. Dexamethasone and Eltrombopag also didn't take. The Doctor's want to try rituximab next and I'm a little bit leary of that one. Then of course, if that doesn't work, they'll want to take my spleen
Pixiellama
in
NRAS
5 years ago
Pelvic MRI on Thursday at MDA
So, thirteen months ago I’m at MD Anderson and bone scans reveal metastasized prostate cancers in bone and lymph nodes in hips - rib cage and sternum as well. PSA was 96 and Gleason was 4+4. Since then the cancer has been suppressed and PSA is negligible. This was accomplished by a combination of injections
So, thirteen months ago I’m at MD Anderson and bone scans reveal metastasized prostate cancers in bone and lymph nodes in hips - rib cage and sternum as well. PSA was 96 and Gleason was 4+4. Since then the cancer has been suppressed and PSA is negligible. This was accomplished by a combination of injections
OldCoach54
in
Advanced Prostate Cancer
5 years ago
White Itchy skin near penis
Does anyone know what is it ? (See image ) It started in late March 2019 . I tried applying clotrimazole , coconut oil but it goes for a day and then again becomes itchy and starts flaking when I scratch there. Please help identifying it..
Does anyone know what is it ? (See image ) It started in late March 2019 . I tried applying clotrimazole , coconut oil but it goes for a day and then again becomes itchy and starts flaking when I scratch there. Please help identifying it..
the_reaper
in
Men's Health Forum (Penis Health)
5 years ago
Need some advice from friends
Age 70 in August Started the fight 6/2011 gleason 8 psa 7 proton radiation. update 9/12/18 psa 4.8 testosterone 13.9 pet scan 3mets pelvis area started zytiga/predisone with 6mths eligard. 4/02/19 psa 2.62 testosterone 8 4/05/19 switched predisone to dexamethasone. (thanks to the advice of this
Age 70 in August Started the fight 6/2011 gleason 8 psa 7 proton radiation. update 9/12/18 psa 4.8 testosterone 13.9 pet scan 3mets pelvis area started zytiga/predisone with 6mths eligard. 4/02/19 psa 2.62 testosterone 8 4/05/19 switched predisone to dexamethasone. (thanks to the advice of this
Racer26
in
Advanced Prostate Cancer
5 years ago
AC225 whilst Chemotherapy Naive
So my Father's PSA has risen whilst on Zytiga and after switching to Dexamethasone. Although that switch from Prednisone did it bring it down for two consecutive months. My father had a recent PSMA scan which shown multiple bone mets but shown the cancer does express PSMA. Am I correct in thinking
So my Father's PSA has risen whilst on Zytiga and after switching to Dexamethasone. Although that switch from Prednisone did it bring it down for two consecutive months. My father had a recent PSMA scan which shown multiple bone mets but shown the cancer does express PSMA. Am I correct in thinking
taylor123
in
Advanced Prostate Cancer
5 years ago
Hiccups after chemotherapy
My husband started chemotherapy with immunotherapy on Monday. With it he had to take dexamethasone steroids and has had hiccups ever since. He had chemotherapy for 4 sessions at the end of last year and had hiccups but they went as soon as he finishes taking the steroids. These hiccups have now been
My husband started chemotherapy with immunotherapy on Monday. With it he had to take dexamethasone steroids and has had hiccups ever since. He had chemotherapy for 4 sessions at the end of last year and had hiccups but they went as soon as he finishes taking the steroids. These hiccups have now been
Spananf
in
The Roy Castle Lung Cancer Foundation
5 years ago
PSA down further and starting Docetaxel today
PSA continued to drop from 0.41 to 0.232. Just started my docetaxel today plus zometa and Lucrin ( ADT). Feeling a bit 'hype' after the treatment. Could be the dexamethasone. Managed to get some rest and feeling fine. Oncologist has asked me to stop the Zytiga when I am going thru the docetaxel treatment
PSA continued to drop from 0.41 to 0.232. Just started my docetaxel today plus zometa and Lucrin ( ADT). Feeling a bit 'hype' after the treatment. Could be the dexamethasone. Managed to get some rest and feeling fine. Oncologist has asked me to stop the Zytiga when I am going thru the docetaxel treatment
bellyhappy58
in
Advanced Prostate Cancer
5 years ago
A possibly interesting publication revealing 10-fold increase in inflammatory molecule in microvascular angina patients.
This post is rather long. My “Google Scholar Alerts” have notified me of a possibly interesting abstract relating to the physiology of microvascular angina (MVA): https://www.ahajournals.org/doi/abs/10.1161/atvb.39.suppl_1.348 The abstract shows that the tested MVA patients had elevated levels of a
This post is rather long. My “Google Scholar Alerts” have notified me of a possibly interesting abstract relating to the physiology of microvascular angina (MVA): https://www.ahajournals.org/doi/abs/10.1161/atvb.39.suppl_1.348 The abstract shows that the tested MVA patients had elevated levels of a
JonathanH
in
British Heart Foundation
5 years ago
Discouraged
Been taking zytiga with trelstar a year now since diagnosis. Initially psa fell quickly from 352 to undetectable, but since May has been doubling monthly. Today it is 0.97. 😔 I sure was hoping to be on this regimen longer. I go back to dr next Thursday. Hoping to try switching prednisone to
Been taking zytiga with trelstar a year now since diagnosis. Initially psa fell quickly from 352 to undetectable, but since May has been doubling monthly. Today it is 0.97. 😔 I sure was hoping to be on this regimen longer. I go back to dr next Thursday. Hoping to try switching prednisone to
Peterd110
in
Advanced Prostate Cancer
5 years ago
Please, help with cortisol
Hi everyone, I’ve just received lab results of low dose Dexamethasone suppression test Cortisol morning <0.03 (0.17-0.50) Doc said it is good(???). I guess it means that I don’t have high cortisol. How about low cortisol? I also tested privately vit D result 66 (65-225). A while ago it was 95(50-150)
Hi everyone, I’ve just received lab results of low dose Dexamethasone suppression test Cortisol morning <0.03 (0.17-0.50) Doc said it is good(???). I guess it means that I don’t have high cortisol. How about low cortisol? I also tested privately vit D result 66 (65-225). A while ago it was 95(50-150)
olga67
in
Thyroid UK
5 years ago
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