Experiences with

Antihemophilic factor

acidity) Pred Prednisone / Prednisolone PT Physiotherapist PTSD Post-traumatic Stress Disorder PV Plasma Viscosity – blood test to detect inflammation QOL Quality of Life RA Rheumatoid Arthritis REMS scan Radiofrequency Echographic Multispectrometry scan to assess bone density RF Rheumatoid factor

[/u] [u][/u] A good example of this is understanding why a GP practice is asking to retest your blood for intrinsic factor antibodies (after a diagnosis of PA) or retest your B12 levels while you are on injections because the guideline is clear that this is not necessary.

In the meantime I had somehow managed to pursaude my GP to do Intrinsic factor and parietal cell antoibody tests - and here's where Im confused - both have come back negative. Does this mean that the cause of B12 deficiency is defintiely not atrophic gastiritis? So this isn't PA?

An intrinsic factor ab test was negative last year.

Told me to take prescription ppi (havent taken yet) I was dx with PA 2 years ago via intrinsic factor antibody, long term megloblastic anemia, neuro symptoms and low normal b12 level. I have never had antibody test for paretal cells.

My test results are as follows: 02/09/24: Intrinsic factor antibody: Laboratory comment: positive; possible pernicious anaemia as low B12; normal Hb 02/09/24: Serum vitamin B12 Laboratory comment: abnormal; 148 ng/L (normal range 182 to 692) 04/12/24: Serum vitamin B12 Laboratory comment: abnormal

So have haematocrit of 0.457 slightly high MCV 101.1 (showing enlarged red blood cells) Active B12 low (34.3 pool/l) Intrinsic factor antibodies negative Gastric parietal cell antibodies negative Any advice on next steps would be appreciated- take vitamins including b12 and eat meat Thanks 🙏

The first time my tests were done, nearly two years ago, my anti-ccp was 79, with Rheumatoid Factor being 264. At the moment, it's mainly my feet that are effected with some bone erosion starting in a couple of MTP joints.

So thankful for your help…I’m so pleased today I had a lovely email from PAS …I’ve got a appointment tomorrow with my gp to start from the beginning (we shall see).. …Im thinking ifab test for PA is either positive or negative no abnormal -satisfactory as mine has wrote in between …but have also

just talking about my previous Dr and when I’m goin to see him next I brought up I was struggling to move and fatigue too many other concerned about possible P.E as close family members have been diagnosed and that a few bloods results being abnormal or higher than expected …especially my intrinsic factor

I’m advised to check my full blood count an intrinsic factor antibodies. Any advise would be very much appreciated

I also mentioned Pernicious Anaemia and Intrinsic Factor needing tested but again very dismissive. I am wondering if this is normal to need to effectively jump through hoops for a simple vitamin check?

I was also told for them to consider a diagnosis of Pernicious Anaemia (apparently backed by a haematology resident consulted by this GP after our phone call) that I would need to have my B12, CBC and Intrinsic Factor Antibodies retested, because they could not rely on results from another GP surgery

Plus thyroid and intrinsic factor anti bodies. I've cut out B complex and taking methyl folate already. Should I stop taking D and the folate before the tests? Thank you 🙏

I asked about b12 but was told normal range( 260), I begged for intrinsic factor test and it came back positive! I had the loading doses then they stopped it, and said 3 months despite me saying nerve pain was still bad, particularly mouth although i ddid have more energy.

Range: 150 - 400) MPV 10.50 fL (Range: 7 - 13) Iron Status Ferritin 86 ug/L Vitamins Folate - Serum 10.43 ug/L (Range: 3.89 - 26.8) Vitamin B12 - Active 58 pmol/L (Range: 37.5 - 150) [u]Methylmalonic acid - Serum X 54.0 ug/L (Range: < 32) [/u] Autoimmunity Intrinsic Factor

They tested for three different antibodies including for pernicious anaemia and rheumatoid factor and these were all negative. I have been off work for almost 6 weeks now and still not feeling any different.

I had my intrinsic factor tested last year and it came back negative, but I've heard that means nothing. I had an FBC Dec 20th last year and my B12 checked. Can anyone recommend a list of blood tests I can request from my GP? I've down loaded the list on the PAS Web site.

Poor absorption owing to a deficiency of Intrinsic Factor (IF) is the underlying reason for PA. Vitamin B12 deficiency in the longer run can lead to nervous system disorders – with sensation changes, loss of power or co-ordination, gut disorders and (rarely) dementia or mental illness.

He has some issues...irritable/impatient/overwhelmed/psyched/lack of energy/disinterested/poor memory/lack of concentration/quick pulse Does anyone think he would benefit from a theraputic course of B12 and maybe some co factors.........should he get his intrinsic factor anitbodies checked first?..