Experiences with

Adenosine

Apparently he found that low levels of receptors of adenosine, a chemical in the brain that regulates neurochemicals, lead to abnormally high levels of glutamate and dopamine. Consequently thereapies that increase adenosine may help with RLS and Dipyridamole may be one.

I have had a spell in hospital between Christmas and New Year with rapid AF and was administered intravenous Adenosine. The doctor who gave it said “It will make you feel like s**t, I mean really s**t. You will think you are going to die.” He was right. Moreover, it didn’t work.

Recently I had a prolonged SVT where I ended up in ER having a shot of adenosine. Three days later I had some bloods and my eGFR came back at 59 (creatinine 104). I checked my bloods I got done last year and the eGFR was 74.

It involves the following drugs: 1) AB928, an adenosine receptor antagonist; 2) AB680, a small molecule inhibitor (CD73 inhibitor); and 3) Zimberelimab, an anti-PD-1. I have done a little research on these drugs but haven't come up with much.

On 26/12/2020 I had an episode of SVT that went on for 5 hours and was taken into hospital where I was given two doses of adenosine (neither of which worked).

Hi All, It's a long time since I last posted but I'm looking for some advice...I will try and briefly summarise my situation.... 2017 - two episodes of SVT two months apart, both needed adenosine to reverse.

New techniques in molecular biology made it possible to isolate and identify a family of receptors on cell surfaces for ATP and its breakdown product adenosine; and Burnstock’s team threw themselves into discovering what happened when they activated or blocked these receptors.

The best guess is that the metoprolol IV-drip they gave me slowed my heart rate enough so that it reset itself and I didn't need Adenosine or a conversion.

- antagonist of adenosine, a substance that reduces the release of dopamine. Caffeine resembles adenosine and competes with it, acting on adenosine receptors, but without activating them.

It seems the problem is both a lack of adenosine (outside cells) and a dysfunction of Adenosine 1 Receptors ( A1R). Please don't rush out or Amazon for adenosine boosters!!!! It appears that too.much adenosine can cause bradycardia and hypotension, crudely put, dropping dead!

They administered Adenosine Tri-Phosphate. After that episode in Feb/Mar I noticed a heady feeling increasingly & a weightiness in my chest. I also had days of trying to breathe air that was thick. Moving legs up the stairs with invisible weights tied to them. Frequent pauses to go up stairs.

In the end I needed an injection (not adenosine as asthmatic), as the two modified vagal manoeuvres made my HR higher. Within a few minutes of the injection I went into sinus rhythm although still up in the 100’s. If that hadn’t worked they were going to do something electrical???

It inhibits VEGF expression by interacting with and inhibiting the production and activation of transcription factor-2, cyclic adenosine monophosphate response binding protein, TNF-α, IL-1β, IL-6, and NF-kB to prevent the metastasis of and angiogenesis in human breast cancer [82,83].

Move forward to December 2019, I got another SVT attack of 210 BPM and had to go to the hospital to have it slowed down with adenosine. I have an appointment to have a second ablation done April 16, 2020 and am feeling worried, dissapointed and scared as the first time.

Adenosine was said to be a player in RLS and one of the most respected RLS doctors said we could look forward to a time when DAs were no longer fist-line drugs. It was even mooted a non-augmenting DA might be on the horizon.

This is the new class of medication: adenosine A24 inhibitor. It doesn't have anything to do with dopamine. It can reduce OFF time by as much as 2 hours. It was used in Japan for quite awhile and now it has been approved in US.

Have a cardiac perfusion MRI on Thurs, with a generous dollop of the playful adenosine to bring back some lovely memories of my heart attack. In the tube about an hour. I actually think I would prefer to be at work.

Back in 2017 there was a paper from Duke, NC: "Acute Myeloid Leukemia After Olaparib Treatment in Metastatic Castration-Resistant Prostate Cancer" "Poly(adenosine diphosphate-ribose) polymerase (PARP) in- hibitors exploit defects in DNA repair to induce tumor-selective cytotoxicity and are in

NADH, Does anyone with or close to someone with Parkinson's have any information and or experience or success with taking NADH?

(Excerpt from the book I am writing now. I hope you find it useful). Is Parkinson's disease a lifestyle disease? 3. Antiparkinsonian lifestyle. What took my father and I the longest to understand was that not only were there lifestyles that increased or decreased risk, but that it was possible to