Experiences with

Adenosine

I have done some research online and it states that Adenosine is used for the scan. My question is whether any one has had any serious side effects to this whilst also being diagnosed with unstable angina/coronary artery spasms and is it safe in these instances?

As I don't want to set it all off again and go to hospital for the dreaded adenosine. But if we had a work night out just to be sociable do you think one would set it off??

I was regularly having to go to hospital for the dreaded adenosine. I had been told chocolate can cause episodes or spicy foods and alcohol. I had noticed if I had an occasional jack daniels I would feel the palpitation. So I don't even have 1 drink now.

Why do they use adenosine rather than a beta blocker (which I did have the first time as they thought initially I'd had a heart attack, before they discovered it was my electrics!). Adenosine is pretty drastic and I'm grateful it works, but it's no fun.

Time to take: I have been taking my medication between 6:30 and 8:30 (shortly after waking up) but I saw a study about how if you wait for about two hours after waking before drinking coffee so that the natural adenosine levels in your body drop so when the caffeine wears off you get less of a crash

I had to have Adenosine 8 times .. they said if it continues to not work I am getting the paddles .. so scarey and it’s playing out that I am absolutely traumatised by the whole 3 day escapade. My HR would just jump upto 265 each time.

At long last I had an angiogram today which showed just a little plaque in two arteries so my cardiologist decided to continue the test with adenosine. We were both surprised to find I do not have MVD despite symptoms. Cardiologist also came to the conclusion that I don’t have spasms either.

What I do know now is that I have the gene variant BTBD9 for poor iron metabolisation, and with it, also poor adenosine build up and low dopamine. I finally got to see a neurologist after over a years’ wait, but it was a pointless visit.

Current treatment options include dopamine precursors, inhibitors of dopamine metabolism, upregulation of autophagy, adenosine A2A antagonists, and surgical intervention as a last resort.

However, dopaminergic drugs are only symptomatic treatments and limited by several side effects. 11  Recent studies into drug development focused on emerging new molecular mechanisms, including  nuclear receptor-related 1 (Nurr1), adenosine receptor A2, nicotine receptor, metabotropic glutamate receptors

“Dipyridamole is proposed to increase coronary blood flow (CBF) by inhibition of adenosine uptake into cells, resulting in an increase in interstitial fluid (ISF) adenosine and an adenosine-mediated vasodilation.” Dipyridamole is also and ENT1 inhibitor.

Antitrypsin A1c Hemoglobin A1c AB Antibody ABG Arterial Blood Gas ABRH ABO Group and Rh Type ABT Antibody Titer ACA Anti-Cardiolipin Antibodies ACE Angiotensin Converting Enzyme ACID PHOS Acid Phosphatase ACP Acid Phosphatase ACT Activated Clotting Time ACTH Adrenocorticotropic Hormone ADA Adenosine

Methods: We proposed a mitochondrial bioenergetic mechanism of radiation-induced fatigue that links impaired oxidative phosphorylation (OXPHOS) via a complex III defect and adenosine triphosphate (ATP) depletion as a result of XRT.

I underwent 2 cardio versions in the emergency department which failed to convert me back to sinus along with two doses of adenosine which also did not work.

Some studies aim to show that the potential benefits of acupuncture depend only on the use of the needles, regardless of where they are inserted, increasing adenosine levels (Goldman 2010). But there are numerous studies that show that they do depend on the insertion point.

“ Most of its effects are attributed to caffeine by the antagonism of adenosine receptors in the central nervous system; however, other coffee constituents like chlorogenic acids have also shown much promise in therapeutic value.

It has been 5 years since my Diagnosis and now 7 years living with PD or from my first symptoms thhat were a little tremor R/H, dry eye, loss of smell. I am now 73 and have posted and joined in others discussions here over the years and have great faith in what I read on many of your posts. Not to re-hash

 There have been very many studies published on the effects of exercise, especially of endurance/aerobic exercise, in restoring the number, the quality and the activity of mitochondria, both in the skeletal muscles, the heart and in the brain neurons. As these are our highest energy demanding tissues

If I was smarter, I might not be so excited about Niacin. I am pretty excited. Niacin in the Central Nervous System: An Update of Biological Aspects and Clinical Applications 2019 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412771/ "Parkinson’s disease (PD) is a progressive disorder characterized

I'm hoping it does for me to save me having to go to a& e for the dreaded adenosine 😁