Experiences with

Adenosine

“Dipyridamole is proposed to increase coronary blood flow (CBF) by inhibition of adenosine uptake into cells, resulting in an increase in interstitial fluid (ISF) adenosine and an adenosine-mediated vasodilation.” Dipyridamole is also and ENT1 inhibitor.

I'm hoping it does for me to save me having to go to a& e for the dreaded adenosine 😁

Hi After another episode of svt this morning and the dreaded adenosine I'm looking into buying a heart rate monitor watch. Can anyone recommend a decent reliable watch that also gives warnings when heart rate is too high.

I underwent 2 cardio versions in the emergency department which failed to convert me back to sinus along with two doses of adenosine which also did not work.

Our findings confirm the eficacy of dipyridamole in restless legs syndrome predicted from preclinical studies and support a key role of adenosine in restless legs syndrome. © 2021 The Authors.

I spoke to the resus doctors about this last week after another episode which always leads to hospital and adenosine. Heart scan and tests show my heart is structurely fine. I have read it can be hormone related with perimenopause etc but resus docs are saying its not possible. I am 51 yrs old.

Hi all, I was just wondering how many of you have experienced a less than comfortable MRI with Adenosine.

https://examine.com/members/deep-dives/article/can-restless-legs-be-ironed-out I don't think it addresses the adenosine side. I will re-read it and add some more thoughtful comments. I would love to hear everyone's impressions.

A more recent development is the experimental use of dipyridamole, which increases adenosine.”

All lesions at 30W No antegrade or retrograde pathway conduction evidence with adenosine At 20mins waiting, AVRT induced (no pre-excitation on baseline ECG) Further lesions at 35W with termination of tachycardia in <2s No recurrence of antegrade or retrograde pathway conduction after 20mins waiting time

I was in A&E on Monday night with a SVT episode, which wouldn’t stop with the usual way I stop it, so had to have an Adenosine injection which worked straight away, my blood pressure was sky high too. They let me out when it went down to normal.

“The Adenosine Hypothesis of Restless Legs Syndrome.” Journal of Caffeine and Adenosine Research 9, no. 1 (March 1, 2019): 1–3. https://doi.org/10.1089/caff.2019.0001. Ferré, Sergi, Christopher Earley, Seema Gulyani, and Diego Garcia-Borreguero.

The iron outside plays a part in normal dopamine and adenosine function, without which RLS can occur.

“Adenosine by the way, regulates the sleepiness associated with prolonged wakefulness,” explains Dr. Ferré. In the cortex, thalamus and other areas of the brain, adenosine modulates homeostatic sleep. Low levels of adenosine receptors could explain the hyperarousal of RLS.

The report said infarction scarring was almost transmural and they had to abort perfusion due to intermittent 2-1 block during Adenosine infusion. My recovery is slow going at the moment and, I am having a few problems.

Hi all, I'm due for an mri stress and contrast test next week. A thought occurred to me. I suffer acute angina and breathlessness after HA and stents and am on a truck load of drugs for it. I have to stop them all 24 hours before the mri and was wondering if the stress part could induce another HA.

I also know that according to some theories dopamine deficiency and/or downreglation of dopamine receptors, glutmate excess and/or an underlying adenosine dysfunction lead to RLS symptoms. I haven't a clue what the connection between the two is.

Some other molecules such as cyclic adenosine monophosphate (31), cytokines (32), and growth factors (33) also induce similar trans-differentiation of LNCaP.

The other night and having the dreaded adenosine they started mentioning ablation again. I'm undecided what to do. I have had ecgs and monitors and scans but they can't find anything wrong with my heart only a slight mitral valve regurgitation which they said is normal for people my age, 50.

The first of these is sleep pressure, the adenosine, (which can be affected by caffeine) The second of these is the GABA Glutamate balance which controls how active neurons are (beyond how much people are thinking).