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Dipyridamole, Adenosine and RLS (Oh My)

“Dipyridamole is proposed to increase coronary blood flow (CBF) by inhibition of adenosine uptake into cells, resulting in an increase in interstitial fluid (ISF) adenosine and an adenosine-mediated vasodilation.” Dipyridamole is also and ENT1 inhibitor.
“Dipyridamole is proposed to increase coronary blood flow (CBF) by inhibition of adenosine uptake into cells, resulting in an increase in interstitial fluid (ISF) adenosine and an adenosine-mediated vasodilation.” Dipyridamole is also and ENT1 inhibitor.
WideBody profile image
WideBody
in Restless Legs Syndrome

How many people taking bisoprolol and flecainide for svt?

I'm hoping it does for me to save me having to go to a& e for the dreaded adenosine 😁
I'm hoping it does for me to save me having to go to a& e for the dreaded adenosine 😁
dawny1908 profile image
dawny1908
in British Heart Foundation

Heart rate monitor... Svt

Hi After another episode of svt this morning and the dreaded adenosine I'm looking into buying a heart rate monitor watch. Can anyone recommend a decent reliable watch that also gives warnings when heart rate is too high.
Hi After another episode of svt this morning and the dreaded adenosine I'm looking into buying a heart rate monitor watch. Can anyone recommend a decent reliable watch that also gives warnings when heart rate is too high.
dawny1908 profile image
dawny1908
in British Heart Foundation
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Afib in a Young Person

I underwent 2 cardio versions in the emergency department which failed to convert me back to sinus along with two doses of adenosine which also did not work.
I underwent 2 cardio versions in the emergency department which failed to convert me back to sinus along with two doses of adenosine which also did not work.
Lc06091 profile image
Lc06091
in AF Association

The key role of adenosine in restless legs syndrome.

Our findings confirm the eficacy of dipyridamole in restless legs syndrome predicted from preclinical studies and support a key role of adenosine in restless legs syndrome. © 2021 The Authors.
Our findings confirm the eficacy of dipyridamole in restless legs syndrome predicted from preclinical studies and support a key role of adenosine in restless legs syndrome. © 2021 The Authors.
Arjiji profile image
Arjiji
in Restless Legs Syndrome

Svt and perimenopause/hormones

I spoke to the resus doctors about this last week after another episode which always leads to hospital and adenosine. Heart scan and tests show my heart is structurely fine. I have read it can be hormone related with perimenopause etc but resus docs are saying its not possible. I am 51 yrs old.
I spoke to the resus doctors about this last week after another episode which always leads to hospital and adenosine. Heart scan and tests show my heart is structurely fine. I have read it can be hormone related with perimenopause etc but resus docs are saying its not possible. I am 51 yrs old.
dawny1908 profile image
dawny1908
in AF Association

MRI with Adenosine

Hi all, I was just wondering how many of you have experienced a less than comfortable MRI with Adenosine.
Hi all, I was just wondering how many of you have experienced a less than comfortable MRI with Adenosine.
tazcat123 profile image
tazcat123
in British Heart Foundation

Excellent Article!

https://examine.com/members/deep-dives/article/can-restless-legs-be-ironed-out I don't think it addresses the adenosine side. I will re-read it and add some more thoughtful comments. I would love to hear everyone's impressions.
https://examine.com/members/deep-dives/article/can-restless-legs-be-ironed-out I don't think it addresses the adenosine side. I will re-read it and add some more thoughtful comments. I would love to hear everyone's impressions.
WideBody profile image
WideBody
in Restless Legs Syndrome

Ellfindoe and LotteM please ....

A more recent development is the experimental use of dipyridamole, which increases adenosine.”
A more recent development is the experimental use of dipyridamole, which increases adenosine.”
67Waterman profile image
67Waterman
in Restless Legs Syndrome

Ablation 4 weeks ago, SVT's have started again. Anyone else? Advice from Cardiologists?

All lesions at 30W No antegrade or retrograde pathway conduction evidence with adenosine At 20mins waiting, AVRT induced (no pre-excitation on baseline ECG) Further lesions at 35W with termination of tachycardia in <2s No recurrence of antegrade or retrograde pathway conduction after 20mins waiting time
All lesions at 30W No antegrade or retrograde pathway conduction evidence with adenosine At 20mins waiting, AVRT induced (no pre-excitation on baseline ECG) Further lesions at 35W with termination of tachycardia in <2s No recurrence of antegrade or retrograde pathway conduction after 20mins waiting time
chriscardio1995 profile image
chriscardio1995
in British Heart Foundation

PAF and SVT

I was in A&E on Monday night with a SVT episode, which wouldn’t stop with the usual way I stop it, so had to have an Adenosine injection which worked straight away, my blood pressure was sky high too. They let me out when it went down to normal.
I was in A&E on Monday night with a SVT episode, which wouldn’t stop with the usual way I stop it, so had to have an Adenosine injection which worked straight away, my blood pressure was sky high too. They let me out when it went down to normal.
Sixtychick profile image
Sixtychick
in AF Association

Reference to the updated "Algorithm" for RLS treatment

“The Adenosine Hypothesis of Restless Legs Syndrome.” Journal of Caffeine and Adenosine Research 9, no. 1 (March 1, 2019): 1–3. https://doi.org/10.1089/caff.2019.0001. Ferré, Sergi, Christopher Earley, Seema Gulyani, and Diego Garcia-Borreguero.
“The Adenosine Hypothesis of Restless Legs Syndrome.” Journal of Caffeine and Adenosine Research 9, no. 1 (March 1, 2019): 1–3. https://doi.org/10.1089/caff.2019.0001. Ferré, Sergi, Christopher Earley, Seema Gulyani, and Diego Garcia-Borreguero.
GuillaumeL profile image
GuillaumeL
in Restless Legs Syndrome

Fred the iron molecules tale : The end

The iron outside plays a part in normal dopamine and adenosine function, without which RLS can occur.
The iron outside plays a part in normal dopamine and adenosine function, without which RLS can occur.
Hidden profile image
Hidden
in Restless Legs Syndrome

Adenosine and Diprydamole

“Adenosine by the way, regulates the sleepiness associated with prolonged wakefulness,” explains Dr. Ferré. In the cortex, thalamus and other areas of the brain, adenosine modulates homeostatic sleep. Low levels of adenosine receptors could explain the hyperarousal of RLS.
“Adenosine by the way, regulates the sleepiness associated with prolonged wakefulness,” explains Dr. Ferré. In the cortex, thalamus and other areas of the brain, adenosine modulates homeostatic sleep. Low levels of adenosine receptors could explain the hyperarousal of RLS.
welschrispy profile image
welschrispy
in Restless Legs Syndrome

Heart Scan

The report said infarction scarring was almost transmural and they had to abort perfusion due to intermittent 2-1 block during Adenosine infusion. My recovery is slow going at the moment and, I am having a few problems.
The report said infarction scarring was almost transmural and they had to abort perfusion due to intermittent 2-1 block during Adenosine infusion. My recovery is slow going at the moment and, I am having a few problems.
driverbadges profile image
driverbadges
in British Heart Foundation

MRI with Adenosine

Hi all, I'm due for an mri stress and contrast test next week. A thought occurred to me. I suffer acute angina and breathlessness after HA and stents and am on a truck load of drugs for it. I have to stop them all 24 hours before the mri and was wondering if the stress part could induce another HA.
Hi all, I'm due for an mri stress and contrast test next week. A thought occurred to me. I suffer acute angina and breathlessness after HA and stents and am on a truck load of drugs for it. I have to stop them all 24 hours before the mri and was wondering if the stress part could induce another HA.
tazcat123 profile image
tazcat123
in British Heart Foundation

Fred the iron molecule, and RLS : A story.

I also know that according to some theories dopamine deficiency and/or downreglation of dopamine receptors, glutmate excess and/or an underlying adenosine dysfunction lead to RLS symptoms. I haven't a clue what the connection between the two is.
I also know that according to some theories dopamine deficiency and/or downreglation of dopamine receptors, glutmate excess and/or an underlying adenosine dysfunction lead to RLS symptoms. I haven't a clue what the connection between the two is.
Hidden profile image
Hidden
in Restless Legs Syndrome

Neuroendocrine Prostate Cancer [NEPC]

Some other molecules such as cyclic adenosine monophosphate (31), cytokines (32), and growth factors (33) also induce similar trans-differentiation of LNCaP.
Some other molecules such as cyclic adenosine monophosphate (31), cytokines (32), and growth factors (33) also induce similar trans-differentiation of LNCaP.
pjoshea13 profile image
pjoshea13
in Advanced Prostate Cancer

Ablation for SVT

The other night and having the dreaded adenosine they started mentioning ablation again. I'm undecided what to do. I have had ecgs and monitors and scans but they can't find anything wrong with my heart only a slight mitral valve regurgitation which they said is normal for people my age, 50.
The other night and having the dreaded adenosine they started mentioning ablation again. I'm undecided what to do. I have had ecgs and monitors and scans but they can't find anything wrong with my heart only a slight mitral valve regurgitation which they said is normal for people my age, 50.
dawny1908 profile image
dawny1908
in British Heart Foundation

Sleep is complicated or perhaps not so much

The first of these is sleep pressure, the adenosine, (which can be affected by caffeine) The second of these is the GABA Glutamate balance which controls how active neurons are (beyond how much people are thinking).
The first of these is sleep pressure, the adenosine, (which can be affected by caffeine) The second of these is the GABA Glutamate balance which controls how active neurons are (beyond how much people are thinking).
Metabobbly profile image
Metabobbly
in Sleep Matters
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