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Adenosine

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Has anyone used Dipyridamole with effect for RLS?

Apparently he found that low levels of receptors of adenosine, a chemical in the brain that regulates neurochemicals, lead to abnormally high levels of glutamate and dopamine. Consequently thereapies that increase adenosine may help with RLS and Dipyridamole may be one.
Apparently he found that low levels of receptors of adenosine, a chemical in the brain that regulates neurochemicals, lead to abnormally high levels of glutamate and dopamine. Consequently thereapies that increase adenosine may help with RLS and Dipyridamole may be one.
mateloch
in Restless Legs Syndrome

Has anyone been given Adenosine?

I have had a spell in hospital between Christmas and New Year with rapid AF and was administered intravenous Adenosine. The doctor who gave it said “It will make you feel like s**t, I mean really s**t. You will think you are going to die.” He was right. Moreover, it didn’t work.
I have had a spell in hospital between Christmas and New Year with rapid AF and was administered intravenous Adenosine. The doctor who gave it said “It will make you feel like s**t, I mean really s**t. You will think you are going to die.” He was right. Moreover, it didn’t work.
spinningjenny
in AF Association

GFR and Heart Issues

Recently I had a prolonged SVT where I ended up in ER having a shot of adenosine. Three days later I had some bloods and my eGFR came back at 59 (creatinine 104). I checked my bloods I got done last year and the eGFR was 74.
Recently I had a prolonged SVT where I ended up in ER having a shot of adenosine. Three days later I had some bloods and my eGFR came back at 59 (creatinine 104). I checked my bloods I got done last year and the eGFR was 74.
Agent_K
in Kidney Disease
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New MD Anderson Trial with Adenosine Receptor Antagonist and Small Molecule Inhibitor

It involves the following drugs: 1) AB928, an adenosine receptor antagonist; 2) AB680, a small molecule inhibitor (CD73 inhibitor); and 3) Zimberelimab, an anti-PD-1. I have done a little research on these drugs but haven't come up with much.
It involves the following drugs: 1) AB928, an adenosine receptor antagonist; 2) AB680, a small molecule inhibitor (CD73 inhibitor); and 3) Zimberelimab, an anti-PD-1. I have done a little research on these drugs but haven't come up with much.
WhiteStrat
in Advanced Prostate Cancer

Bisoprolol 2.5mg for SVT

On 26/12/2020 I had an episode of SVT that went on for 5 hours and was taken into hospital where I was given two doses of adenosine (neither of which worked).
On 26/12/2020 I had an episode of SVT that went on for 5 hours and was taken into hospital where I was given two doses of adenosine (neither of which worked).
KylieSmath1234
in British Heart Foundation

Bisoprolol issues and weaning off

Hi All, It's a long time since I last posted but I'm looking for some advice...I will try and briefly summarise my situation.... 2017 - two episodes of SVT two months apart, both needed adenosine to reverse.
Hi All, It's a long time since I last posted but I'm looking for some advice...I will try and briefly summarise my situation.... 2017 - two episodes of SVT two months apart, both needed adenosine to reverse.
daisy2311
in British Heart Foundation

Geoffrey Burnstock [age 91] obituary | Shifted ATP paradigm - gut nerves | Neuroscience | The Guardian

New techniques in molecular biology made it possible to isolate and identify a family of receptors on cell surfaces for ATP and its breakdown product adenosine; and Burnstock’s team threw themselves into discovering what happened when they activated or blocked these receptors.
New techniques in molecular biology made it possible to isolate and identify a family of receptors on cell surfaces for ATP and its breakdown product adenosine; and Burnstock’s team threw themselves into discovering what happened when they activated or blocked these receptors.
aspergerian
in Parkinson's Movement

Update re Emergency Room trip etc

The best guess is that the metoprolol IV-drip they gave me slowed my heart rate enough so that it reset itself and I didn't need Adenosine or a conversion.
The best guess is that the metoprolol IV-drip they gave me slowed my heart rate enough so that it reset itself and I didn't need Adenosine or a conversion.
Doggiemomma
in AF Association

Coffee and Parkinson's disease. The incredible effects of this drink.

- antagonist of adenosine, a substance that reduces the release of dopamine. Caffeine resembles adenosine and competes with it, acting on adenosine receptors, but without activating them.
- antagonist of adenosine, a substance that reduces the release of dopamine. Caffeine resembles adenosine and competes with it, acting on adenosine receptors, but without activating them.
parkinsonshereandnow
in Parkinson's Movement

Dipyridamole :Another false dawn?

It seems the problem is both a lack of adenosine (outside cells) and a dysfunction of Adenosine 1 Receptors ( A1R). Please don't rush out or Amazon for adenosine boosters!!!! It appears that too.much adenosine can cause bradycardia and hypotension, crudely put, dropping dead!
It seems the problem is both a lack of adenosine (outside cells) and a dysfunction of Adenosine 1 Receptors ( A1R). Please don't rush out or Amazon for adenosine boosters!!!! It appears that too.much adenosine can cause bradycardia and hypotension, crudely put, dropping dead!
Manerva
in Restless Legs Syndrome

I think I’m a hypochondriac, I suspect they do too!

They administered Adenosine Tri-Phosphate. After that episode in Feb/Mar I noticed a heady feeling increasingly & a weightiness in my chest. I also had days of trying to breathe air that was thick. Moving legs up the stairs with invisible weights tied to them. Frequent pauses to go up stairs.
They administered Adenosine Tri-Phosphate. After that episode in Feb/Mar I noticed a heady feeling increasingly & a weightiness in my chest. I also had days of trying to breathe air that was thick. Moving legs up the stairs with invisible weights tied to them. Frequent pauses to go up stairs.
BritTania
in British Heart Foundation

Anxious starting Tildiem for SVT’s

In the end I needed an injection (not adenosine as asthmatic), as the two modified vagal manoeuvres made my HR higher. Within a few minutes of the injection I went into sinus rhythm although still up in the 100’s. If that hadn’t worked they were going to do something electrical???
In the end I needed an injection (not adenosine as asthmatic), as the two modified vagal manoeuvres made my HR higher. Within a few minutes of the injection I went into sinus rhythm although still up in the 100’s. If that hadn’t worked they were going to do something electrical???
Gracey888
in British Heart Foundation

VEGF Inhibitors.

It inhibits VEGF expression by interacting with and inhibiting the production and activation of transcription factor-2, cyclic adenosine monophosphate response binding protein, TNF-α, IL-1β, IL-6, and NF-kB to prevent the metastasis of and angiogenesis in human breast cancer [82,83].
It inhibits VEGF expression by interacting with and inhibiting the production and activation of transcription factor-2, cyclic adenosine monophosphate response binding protein, TNF-α, IL-1β, IL-6, and NF-kB to prevent the metastasis of and angiogenesis in human breast cancer [82,83].
pjoshea13
in Advanced Prostate Cancer

Second ablation for SVT

Move forward to December 2019, I got another SVT attack of 210 BPM and had to go to the hospital to have it slowed down with adenosine. I have an appointment to have a second ablation done April 16, 2020 and am feeling worried, dissapointed and scared as the first time.
Move forward to December 2019, I got another SVT attack of 210 BPM and had to go to the hospital to have it slowed down with adenosine. I have an appointment to have a second ablation done April 16, 2020 and am feeling worried, dissapointed and scared as the first time.
Paula27
in AF Association

Optimism, anyone?

Adenosine was said to be a player in RLS and one of the most respected RLS doctors said we could look forward to a time when DAs were no longer fist-line drugs. It was even mooted a non-augmenting DA might be on the horizon.
Adenosine was said to be a player in RLS and one of the most respected RLS doctors said we could look forward to a time when DAs were no longer fist-line drugs. It was even mooted a non-augmenting DA might be on the horizon.
rkatt
in Restless Legs Syndrome

Nourianz new medication to reduce off time

This is the new class of medication: adenosine A24 inhibitor. It doesn't have anything to do with dopamine. It can reduce OFF time by as much as 2 hours. It was used in Japan for quite awhile and now it has been approved in US.
This is the new class of medication: adenosine A24 inhibitor. It doesn't have anything to do with dopamine. It can reduce OFF time by as much as 2 hours. It was used in Japan for quite awhile and now it has been approved in US.
felixned
in Parkinson's Movement

Stress MRI

Have a cardiac perfusion MRI on Thurs, with a generous dollop of the playful adenosine to bring back some lovely memories of my heart attack. In the tube about an hour. I actually think I would prefer to be at work.
Have a cardiac perfusion MRI on Thurs, with a generous dollop of the playful adenosine to bring back some lovely memories of my heart attack. In the tube about an hour. I actually think I would prefer to be at work.
Sillyfroggy
in British Heart Foundation

Parp Inhibitors - what are the risks?

Back in 2017 there was a paper from Duke, NC: "Acute Myeloid Leukemia After Olaparib Treatment in Metastatic Castration-Resistant Prostate Cancer" "Poly(adenosine diphosphate-ribose) polymerase (PARP) in- hibitors exploit defects in DNA repair to induce tumor-selective cytotoxicity and are in
Back in 2017 there was a paper from Duke, NC: "Acute Myeloid Leukemia After Olaparib Treatment in Metastatic Castration-Resistant Prostate Cancer" "Poly(adenosine diphosphate-ribose) polymerase (PARP) in- hibitors exploit defects in DNA repair to induce tumor-selective cytotoxicity and are in
pjoshea13
in Advanced Prostate Cancer

NADH, INFORMATION NEEDED

NADH, Does anyone with or close to someone with Parkinson's have any information and or experience or success with taking NADH?
NADH, Does anyone with or close to someone with Parkinson's have any information and or experience or success with taking NADH?
CapSage
in Parkinson's Movement

3. Antiparkinsonian lifestyle.

(Excerpt from the book I am writing now. I hope you find it useful). Is Parkinson's disease a lifestyle disease? 3. Antiparkinsonian lifestyle. What took my father and I the longest to understand was that not only were there lifestyles that increased or decreased risk, but that it was possible to
(Excerpt from the book I am writing now. I hope you find it useful). Is Parkinson's disease a lifestyle disease? 3. Antiparkinsonian lifestyle. What took my father and I the longest to understand was that not only were there lifestyles that increased or decreased risk, but that it was possible to
parkinsonshereandnow
in Parkinson's Movement
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