Gold Nanoparticles May Offer Benefit To People With PD By Reducing Brain Deficits

[chartist]

Quite a few years ago I tested gold nanoparticles (AuNPs), which I made myself, for about two months for their purported ability to enhance mental function. Unfortunately I was not able to discern any improvement other than improved sleep.

Properly made AuNPs will be a ruby red color. Here are some images of AuNPs from a supplier :

fortislife.com/gold-nanopar...

The AuNPs I made were closest in color to the 4th vial from the left in the above link and I would describe what I made as ruby red in color and crystal clear with no obvious turbidity of the suspension. The reason I made my own AuNPs is because it is too expensive to buy from retailers and suppliers in the quantities I was consuming, which was 500 ml/day in two divided doses at 40 ppm. Here is a link to AuNPs on Amazon to give you an idea of how expensive they can be at the amount I was consuming per day :

amazon.com/MMediGOLD-ppm-Tr...

Part of the reason I chose to test AuNPs is because I had already been testing silver nanoparticles (AgNPs) that I made myself for years and finding some useable health benefits with AgNPs. The other reason I decided to test AuNPs is because of their purported anti inflammatory activities throughout the body, including the brain. Here is a link to a 2023 article discussing the anti inflammatory effects of AuNPs as might apply to Alzheimer's disease (AD) :

pubs.rsc.org/en/content/art....

Here is a relevant article quote :

' AuNPs reduce neuroinflammation by inducing macrophage polarization toward the M2 phenotype, reducing pro-inflammatory cytokine expression, blocking leukocyte adhesion, and decreasing oxidative stress. Therefore, AuNPs are gradually attracting the interest of scholars and are used for treating inflammatory diseases and drug delivery. Herein, we explored the role and mechanism of AuNPs in treating neuroinflammation in AD. The use of AuNPs for treating AD is a topic worth exploring in the future, not only to help solve a global public health problem but also to provide a reference for treating other neuroinflammatory diseases. '

The above was just to give some background on my interest in AuNPs. Today, I came across what I consider an interesting 2024 article discussing the potential use of AuNPs for PD and MS :

utsouthwestern.edu/newsroom...

Here is a relevant quote from the article :

' Together, the 24 patients had an average increase in their NAD+/NADH ratios of 10.4% compared with baseline, showing that CNM-Au8 was targeting the brain as intended. Other energetic molecules, including ATP, normalized to the group mean by the end of treatment, another potentially beneficial effect. Using a validated survey for functional outcomes in PD, researchers found that study patients with this condition reported improved “motor experiences of daily living” at one point, suggesting that taking CNM-Au8 could ameliorate functional symptoms of their disease. None of the patients experienced severe adverse side effects linked to CNM-Au8. '

The following human study further illustrates the anti inflammatory effects of AuNPs in people with arthritis :

mdpi.com/2411-5142/7/3/52

Here is a relevant quote from the human study using AuNPs in patients with arthritis :

' The study found patients’ Knee injury and Osteoarthritis Outcome Score (KOOS) improved with statistical significance. It was reported that 71.42% of the cohort experienced improvements in their perceived knee pain and 61.22% with improvements in knee stiffness. Majority of objective measurements such as pain with range of motion and specific exercises requiring proper knee health and function did not show statistically significant improvement but did show a positive improving trend in support of AuNP supplement. Study cohort showed statistically significant improvements in two specific exercises: sit-to-stand and single-leg squat. By the end of the study, 70% of the study cohort indicated that they would continue to take the supplement even after the study concluded. '

Lastly I would like to add the following study sent to me by forum member  enjoy2013

which indicated that AuNPs also showed benefit in people with ALS by decreasing all cause mortality at 12 months by 60% and potentially slowed disease progression as discussed here :

pmc.ncbi.nlm.nih.gov/articl...

AuNPs are generally considered to have a very good safety profile at therapeutic dosing levels and the results described in the above article tend to confirm that idea. AuNPs are readily available over the counter, but expensive as such. If they are able to effectively extend their research, AuNPs may qualify for insurance coverage making it much more affordable for regular use in multiple disease states while having a very good safety profile at the dosing that might be required.

Art

[gomelgo]

I had no idea this was even a thing! Interesting. Weren't there nanoparticles in the vaccines, and wasn't that kind of a negative thing though?

[chartist in reply to gomelgo]

I think nanoparticles tend to encompass a lot of information, ideas and applications, but as an example, with silver nanoparticles (AgNPs), they are actually larger (1-100 nm) than silver ions which are very significantly less than 1 nm. The AgNPs are actually filled with many silver ions and the AgNPs move into the blood circulatory system potentially through, direct injection, inhalation or oral consumption as three typical delivery methods. Once in the circulatory system, if they come in contact with a pathogen, the AgNPs will breach the cell wall of the pathogenic bacteria and release silver ions into the breach which will destroy the pathogen from the inside out. In this case the silver nanoparticles are acting as a delivery device of sorts for the silver ions. Silver ions on their own are so small they can pass directly through cell walls and once they react and bind with other particles inside the cell, they can become too large to be able to exit the cell, which if this happens enough can result in blue/gray skin which is called argyria and is generally considered irreversible except possibly reversible with the use of newer forms of laser application, but I have not seen actual studies confirming this effect . I have never seen any literature confirming that true AgNPs have ever caused argyria. In the case of silver ions (Ag+), they are thought to have potential to cause argyria, but the amount that would have to be taken in over a very extended period of time, would be extraordinarily large amounts that there is currently no medical condition that would require such a large amount. AgNPs are what is typically used in most studies, with Ag+ mainly used for comparison purposes.

Sometimes nanoparticles are used as an aid to improve topical application absorption and dispersion of other molecules.

In general, AgNPs are considered to be more effective than ionic silver for this purpose. This of course is just looking exclusively at AgNPs and AuNPs and some of their known activities, whereas there is more involved in vaccines and I don't think simple comparisons can be made.

A lot of the research involving AuNPs involves their anti inflammatory properties. Both AuNPs and AgNPs are known to cross the blood brain barrier (BBB), at least in animal studies.

Art

[gomelgo in reply to chartist]

Thanks Art. Another thing is that I recently had my hair analysis done and I have silver way above normal levels. Is that relevant?

[chartist in reply to gomelgo]

Well not relevant to the AuNPs aspect of the original article. As far as AgNPs, they are naturally eliminated from the body at a rate that depends on the particle size and total intake over a set period of time. So had you used AgNPs as a potential treatment for something like Covid-19 over a period of two weeks, those should have been eliminated from your system over a period of less than two months, but the elimination rate will vary based on the dosage used, the actual length of use and the actual size of the AgNPs used. While AgNPs accumulate differently than silver from occupational exposure, regular silver can have a contributing effect to the potential for argyria, whereas no studies that I am aware of have directly attributed AgNPs as a cause for argyria.

Art

[gomelgo in reply to chartist]

argyria?

[chartist in reply to gomelgo]

en.wikipedia.org/wiki/Argyria

Art

[Kat343]

Art! You always come up with great stuff. I am a huge believer in the colloid metals and have used gallons of Mesosilver for many many things. I literally just got my gallon of Mesogold yesterday for HWP and me - for brain health! I do not know the mechanism of how it works, but quickly looking over your articles, I think we are talking about the same thing. yes, its expensive, but I am affording it and will start it tomorrow - 1 tablespoon on an empty stomach. I tried a small bottle last month and think it helped me with my ... caregiver brain, Anyway, I have done silver, a little platinum and copper, all from the same company. I have done a ton of research on the silver and the only company I can recommend are the products from purestcolloids.com. I order them from colloidsforlife.com since they offer free shipping and are in my state. Plus, they are great to talk to when I have questions. So, your post is perfectly timed.

I'll try and post back in a month or so about how they are working. I also ordered more silver and copper and will make a little 'cocktail' with gold, silver and copper. PS. I tried the platinum for husbands prostrate cancer, but he only wanted to go the surgery route, even tho his PSA had gone down after 6 weeks of platinum use.

Anyway, I do wish it was less expensive, but the products I mentioned are really top notch! Thank you.

[Boscoejean]

how are gold nanoparticles made?

[chartist in reply to Boscoejean]

You have to use gold chloride as the base, which is yellow in color.

Art

[Boscoejean in reply to chartist]

do you have a little chemistry lab? Is this similar to the process you used? how does the cost of making your own nanoparticles compare with buying them as a supplement?

"To make gold nanoparticles using gold chloride, you typically dissolve gold chloride (usually in the form of tetrachloroauric acid, HAuCl4) in water, then add a reducing agent like sodium citrate, which chemically reduces the gold ions to metallic gold atoms, causing them to aggregate and form nanoparticles; the size and stability of these nanoparticles can be controlled by adjusting the reaction conditions like temperature, pH, and the concentration of the reducing agent and stabilizing agents.

Key steps:

Prepare a gold chloride solution: Dissolve a measured amount of gold chloride (HAuCl4) in deionized water.

Heat the solution: Bring the gold chloride solution to a boiling point while stirring.

Add reducing agent: Rapidly add a solution of a reducing agent like sodium citrate to the boiling gold chloride solution.

Observe color change: The solution will change color as the gold nanoparticles form, typically turning from yellow to red depending on the size of the nanoparticles.

Important factors to consider:

Reducing agent selection:

Different reducing agents can influence the size and stability of the gold nanoparticles.

Stabilizing agent:

To prevent the nanoparticles from aggregating, a stabilizing agent like citrate or a surfactant can be added to the solution.

Temperature control:

Precise temperature control is crucial to achieve consistent nanoparticle size"

[chartist in reply to Boscoejean]

I will have to try and find my formulation as that was many years ago. I did not have to worry about long term stability as I made it fresh every morning and every afternoon. Stability is an issue with AuNPs, whereas not so much with AgNPs, so making it fresh each day avoided that problem. My AgNPs have shown stability for years with no agglomeration after years of storage with yellow 20 or 30 ppm.

It would take less than 5 minutes to make a cup. It was very significantly less expensive than retail mixes. The main expense was buying the gold chloride in a small bottle. I would drink the batch in a cup and it seemed similar to drinking tea, but with no flavor. It was consistently the ruby red color.

Art

[Boscoejean in reply to chartist]

since it is being used in clinical trials especially in MS I guess the hope would be that it would become an accepted form of treatment in fact the MS clinical research seems to be ongoing and even considering the cost it seems likely that the cost would come in significantly lower than a lot of other prescriptions that are routinely used

[chartist in reply to Boscoejean]

Agreed, the actual cost has to be significantly less that standard drugs for MS! AuNPs have a very good safety profile at typical dosing levels and I experienced no adverse events from my test of it and have not heard of others who experienced adverse events, but that is limited experience on my part.

Art

[Boscoejean]

clene.com/about-cnm-au8/

[Kat343]

Hi all, I just looked up specific costs and a gallon of the MesoGold, on colloidsforlife.com is $249 with free shipping in the USA, and a gallon has 256 Tablespoons, so its about $1 a day. It may be affordable for some!

[chartist in reply to Kat343]

Please keep in mind that I was taking a total of 500 ml/day of AuNPs at 40 ppm, which is considered a high dose. Based on that, you would burn through that gallon in just 4 days since their product is only 20ppm. What I made at home back when I tested it, cost less than $100/month at the price of gold chloride back then which was years ago.

Art

[Kat343 in reply to chartist]

Holy Cow - that is huge difference. Did you notice any improvement with your overall cognitive abilities? Thanks for letting me know! I'm going to up his dose a bit now and again in a couple of weeks.

[chartist in reply to Kat343]

The only benefit I found at the dose I was taking was improved sleep for the first month, but not the second month. No cognitive improvement that I could discern, but I did not think I had any cognitive deficits at the time of testing.

Art

[Kat343]

Ok, I'll keep an eye on that since HWP wakes up every night at 0330.... ugh for both of us. It would be great to get more sleep for both os us! Thank you again Art, you are such a great source for all of us!

[chartist in reply to Kat343]

For more or better sleep, you might give this consideration, it is what I use in conjunction with melatonin to good effect :

healthunlocked.com/cure-par...

Art

[Kat343]

Ok, it sounds promising, as you probably know, its just hard to add anything new. HWP swallowing is getting worse (as well as his voice) so I normally crush or open pills into yogurt. However, I will try this on my next order as his sleep is critical for both of us! Thank you, I did a bit of research and found this brand - Codeage Liposomal Apigenin Supplement Flavonoid Chamomile Extract - Phospholipids. I love phospholipids and lysosomal, just wonder if those additions may make it more absorbable. Thank you Again Art! Glad you are here on this journey with all of us. Blessings to you!

[chartist in reply to Kat343]

Even if it is only a modest gain over standard, the 100 mg dose is very useful for me.

Art