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MF review article : Treatment options 2019
Hi. This is a very clear summary of treatment options. Just google MF and Ruxolitinib , and the article summary comes up. You can also print off a PDF of the whole article, if you are lucky. Worth showing to your haematologist. Myelofibrosis in 2019: moving beyond JAK2 inhibition” Schieber et al. Blood
Hi. This is a very clear summary of treatment options. Just google MF and Ruxolitinib , and the article summary comes up. You can also print off a PDF of the whole article, if you are lucky. Worth showing to your haematologist. Myelofibrosis in 2019: moving beyond JAK2 inhibition” Schieber et al. Blood
Rachelthepotter
in
MPN Voice
5 years ago
YABTKi or Yet Another BTK inhibitor - the A to Z list of Bruton's Tyrosine Kinase Inhibitors for CLL following Ibrutinib's success
I'll admit that YABTKi is not a recognised CLL related acronym, (acronym lists are here https://healthunlocked.com/cllsupport/posts/private/134932756/cll-abbreviations-in-one-post ), but perhaps it should be! I've attempted in this post to keep tabs on the growing list of BTK inhibitor (BTKi) drugs
I'll admit that YABTKi is not a recognised CLL related acronym, (acronym lists are here https://healthunlocked.com/cllsupport/posts/private/134932756/cll-abbreviations-in-one-post ), but perhaps it should be! I've attempted in this post to keep tabs on the growing list of BTK inhibitor (BTKi) drugs
AussieNeil
Partner
in
CLL Support
5 years ago
WEIGHT GAINS WITH JAKAFI
Post by MPN-MATE Admin » Sat Nov 23, 2019 9:53 pm Hey guys... :D As someone who is taking Ruxolitinib, I found this paper's frank admissions rather interesting seeing that the funding is coming from the manufacturers of Ruxolitinib (Jakafi). It is definitely worth a good read, as it explains how
Post by MPN-MATE Admin » Sat Nov 23, 2019 9:53 pm Hey guys... :D As someone who is taking Ruxolitinib, I found this paper's frank admissions rather interesting seeing that the funding is coming from the manufacturers of Ruxolitinib (Jakafi). It is definitely worth a good read, as it explains how
socrates_8
in
MPN Voice
5 years ago
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CLL Society Support Group Meetings USA Coming Up!
CLL Society Support Group Meetings Coming Up! https://myemail.constantcontact.com/CLL-Society-Alert----December-3--2019.html?soid=1120967015548&aid=3A0RRuM8V-s https://cllsociety.org/events/ - San Diego CLL Society Support and Education Meeting - December 4 @ 4:00 pm - New Orleans and Surrounding
CLL Society Support Group Meetings Coming Up! https://myemail.constantcontact.com/CLL-Society-Alert----December-3--2019.html?soid=1120967015548&aid=3A0RRuM8V-s https://cllsociety.org/events/ - San Diego CLL Society Support and Education Meeting - December 4 @ 4:00 pm - New Orleans and Surrounding
lankisterguy
Volunteer
in
CLL Support
5 years ago
Test Before Treat
Test Before Treat™ Although this comes from the USA, the logic and reasoning can apply to any international patient and medical professionals. https://cllsociety.org/wp-content/uploads/2019/08/Test-Before-Treat-One-pager-V3.pdf "More Patients Spill the Beans on their Test Before Treat™ Experiences
Test Before Treat™ Although this comes from the USA, the logic and reasoning can apply to any international patient and medical professionals. https://cllsociety.org/wp-content/uploads/2019/08/Test-Before-Treat-One-pager-V3.pdf "More Patients Spill the Beans on their Test Before Treat™ Experiences
lankisterguy
Volunteer
in
CLL Support
5 years ago
Venetoclax Added to Ibrutinib in High-Risk CLL Achieves a High Rate of Undetectable Minimal Residual Disease.
December 8, 2019 ASH poster. There are lots of us on long term Ibrutinib who have had a good response but still have a small amount of residual disease. I would welcome the chance to add venetoclax to my treatment as in this study which is an important piece of work by Michael J Keating et al. "[i]Patients
December 8, 2019 ASH poster. There are lots of us on long term Ibrutinib who have had a good response but still have a small amount of residual disease. I would welcome the chance to add venetoclax to my treatment as in this study which is an important piece of work by Michael J Keating et al. "[i]Patients
Jm954
Administrator
in
CLL Support
5 years ago
The TP53 mutational landscape in CLL is very complex
December 8, 2019 Interesting poster shedding a bit more light on the complexity of TP53 mutations and its independence from 17p deletion. [i]"TP53 aberrations, including somatic mutations of TP53 gene or 17p deletion leading to the loss of the TP53 locus, are a major predictive factor of resistance to
December 8, 2019 Interesting poster shedding a bit more light on the complexity of TP53 mutations and its independence from 17p deletion. [i]"TP53 aberrations, including somatic mutations of TP53 gene or 17p deletion leading to the loss of the TP53 locus, are a major predictive factor of resistance to
Jm954
Administrator
in
CLL Support
5 years ago
Transformation Confirmed - Likely Richter’s
My doctor called yesterday and confirmed my PET from last week shows definite transformation and the PA called today to say it’s likely Richter’s (forgot to ask if confirmed by the biopsy - still shock) and they want to start treatment this week. I’m headed back to Houston for consult and planning.
My doctor called yesterday and confirmed my PET from last week shows definite transformation and the PA called today to say it’s likely Richter’s (forgot to ask if confirmed by the biopsy - still shock) and they want to start treatment this week. I’m headed back to Houston for consult and planning.
SarasotaPaul
in
CLL Support
5 years ago
CD3xCD19 Dart Treatment Is Efficient in Venetoclax Resistant CLL and Reverses T Cell Dysfunction
DART (rather than CART) treatment could be come important in the future, especially for CLL where the T cells become exhausted and don't function appropriately. We often think that Venetoclax works for everyone but sadly that isn't true and this in vitro (lab) study on CLL cells, although at very early
DART (rather than CART) treatment could be come important in the future, especially for CLL where the T cells become exhausted and don't function appropriately. We often think that Venetoclax works for everyone but sadly that isn't true and this in vitro (lab) study on CLL cells, although at very early
Jm954
Administrator
in
CLL Support
5 years ago
Does taking Nplate causes nose bleed ?
I'm currently in week 3 of taking Nplate. It could boost my platelet count to 32 however I have nosebleed sometimes recently. I was wondering if it's a side effect of NPlate or something serious?
I'm currently in week 3 of taking Nplate. It could boost my platelet count to 32 however I have nosebleed sometimes recently. I was wondering if it's a side effect of NPlate or something serious?
farasad2001
in
ITP Support Association
5 years ago
Long time DX,SORT TIME TMT
I was diagnosed with CLL in 1995. I’ve been on W&W until this year in Sept. at age 86. Treatment was initiated Ibrutinib 140mg, orally per diem. I’ve positive movement with my numbers and the splenomegaly. My nodes were minimally involved. My side effects have been undetectable. Given good response
I was diagnosed with CLL in 1995. I’ve been on W&W until this year in Sept. at age 86. Treatment was initiated Ibrutinib 140mg, orally per diem. I’ve positive movement with my numbers and the splenomegaly. My nodes were minimally involved. My side effects have been undetectable. Given good response
desti
in
CLL Support
5 years ago
No fear and so grateful for Mutation diagnoses
So for the past eight years since starting treatment for ET I was in chronic all over skeletal pain also neurological (all from medication as I had NO pain before). I now have Myelofibrosis and to be honest am over the moon!! Instead of it being a negative it’s like I have a life worth living again.
So for the past eight years since starting treatment for ET I was in chronic all over skeletal pain also neurological (all from medication as I had NO pain before). I now have Myelofibrosis and to be honest am over the moon!! Instead of it being a negative it’s like I have a life worth living again.
StreetPastor
in
MPN Voice
5 years ago
Dr Michael Keating's Story - Taking CLL Therapies From Bedside to Community
A fascinating overview of one of the giants in CLL research, who provided many of us with the first treatment capable of prolonging life expectancy (FCR) and for about 60% of those who are mutated IgHV, effectively a cure. From humble beginnings in Melbourne Australia, to a fulfilling career at the
A fascinating overview of one of the giants in CLL research, who provided many of us with the first treatment capable of prolonging life expectancy (FCR) and for about 60% of those who are mutated IgHV, effectively a cure. From humble beginnings in Melbourne Australia, to a fulfilling career at the
AussieNeil
Partner
in
CLL Support
5 years ago
IVGH results
Hello. I am new to the group, just diagnosed this month. My last CBC showed absolute lymphocytes at 5280. I was feeling pretty good after my doctor explained what CLL is, how it progresses etc. But today I got results of another test back with the following: IVGH Borderline Mutated Mutation Rate 3.0
Hello. I am new to the group, just diagnosed this month. My last CBC showed absolute lymphocytes at 5280. I was feeling pretty good after my doctor explained what CLL is, how it progresses etc. But today I got results of another test back with the following: IVGH Borderline Mutated Mutation Rate 3.0
lmav
in
CLL Support
5 years ago
Clinical Utility of Chromosomal Microarray in Richter's Transformation
Chromosomal microarray (CMA) is clever, very sensitive technology which looks for extra (duplicated) or missing (deleted) chromosomal segments, sometimes called copy number variants (CNVs) - see illustration. These include: microdeletions and microduplications of chromosome segments, which are too
Chromosomal microarray (CMA) is clever, very sensitive technology which looks for extra (duplicated) or missing (deleted) chromosomal segments, sometimes called copy number variants (CNVs) - see illustration. These include: microdeletions and microduplications of chromosome segments, which are too
Jm954
Administrator
in
CLL Support
5 years ago
Researchers examine the metabolic effects of an oral blood cancer drug ~ RUXOLITINIB (Jakafi)
Post by MPN-MATE Admin » Wed Nov 13, 2019 11:14 am NOV. 12, 2019
Researchers examine the metabolic effects of an oral blood cancer drug...
by The Mount Sinai Hospital Hi guys... This report from the Mount Sinai Hospital is yet to be properly validated. However, many of us may have already read
Post by MPN-MATE Admin » Wed Nov 13, 2019 11:14 am NOV. 12, 2019
Researchers examine the metabolic effects of an oral blood cancer drug...
by The Mount Sinai Hospital Hi guys... This report from the Mount Sinai Hospital is yet to be properly validated. However, many of us may have already read
socrates_8
in
MPN Voice
5 years ago
CALQUENCE gets FDA approval for treating CLL
The latest approval for Calquence (acalabrutinib), a Bruton tyrosine kinase (BTK) inhibitor, was granted under the FDA’s Real-Time Oncology Review and newly established Project Orbis programs. Calquence binds covalently to BTK, thereby inhibiting its activity. In B-cells, BTK signaling results in activation
The latest approval for Calquence (acalabrutinib), a Bruton tyrosine kinase (BTK) inhibitor, was granted under the FDA’s Real-Time Oncology Review and newly established Project Orbis programs. Calquence binds covalently to BTK, thereby inhibiting its activity. In B-cells, BTK signaling results in activation
Myrddin
in
CLL Support
5 years ago
Cancer Fatigue and Getting Through the Holidays
The Leukemia & Lymphoma Society is offering a Free Telephone Support Program for Patients Families and Caregivers. - Click this link to register: https://pburkhard.wufoo.com/forms/qrfew60160p1a4/ or http://bit.ly/DecLnL. Cancer Fatigue and Getting Through the Holidays When: Wednesday
The Leukemia & Lymphoma Society is offering a Free Telephone Support Program for Patients Families and Caregivers. - Click this link to register: https://pburkhard.wufoo.com/forms/qrfew60160p1a4/ or http://bit.ly/DecLnL. Cancer Fatigue and Getting Through the Holidays When: Wednesday
lankisterguy
Volunteer
in
CLL Support
5 years ago
MDS UK Patient Support (pinned post)
Approx. 20% of Sweet's syndrome (SS) patients develop their condition secondary to cancer, the commonest being a group of blood disorders called myelodysplastic syndromes (MDS) and
acute
myeloid
leukaemia
(MDS can progress to AML).
Approx. 20% of Sweet's syndrome (SS) patients develop their condition secondary to cancer, the commonest being a group of blood disorders called myelodysplastic syndromes (MDS) and
acute
myeloid
leukaemia
(MDS can progress to AML).
Shell567
Sweet's Syndrome UK
in
Sweet's Syndrome UK
5 years ago
Blood cancers: New generation stem cell transplant significantly reduces complications for patients
Post by MPN-MATE Admin » Wed Nov 06, 2019 9:21 am Hey everyone... :-) More great good news is coming our way... This article has already successfully run 'Human Trials', and in the USA, it's about to be accepted by the FDA for a Phase III Clinical Trial... Impressive results as you will see from reading
Post by MPN-MATE Admin » Wed Nov 06, 2019 9:21 am Hey everyone... :-) More great good news is coming our way... This article has already successfully run 'Human Trials', and in the USA, it's about to be accepted by the FDA for a Phase III Clinical Trial... Impressive results as you will see from reading
socrates_8
in
MPN Voice
5 years ago
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