Experiences with

Acute leukaemia

will be needed a stem cell transplant after my third round for Flagida Chemotherapy. Has anyone had similar?

As my father died 3 days after his diagnosis of Acute Myeloid Leukaemia I am feeling concerned about the rapid changes I am experiencing. I have known my haematologist for over 14 years as he was also my husband's consultant for his Mantel Cell Lymphoma.

"CDKI-73 is currently being investigated in Phase 2 clinical trials in patients with relapsed and therapy-resistant acute myeloid leukaemia, an aggressive blood cancer."

My husband has myelofibrosis after polycythemia. He has been taking ruxolitinib for 9 years. Over the past year, he has lost 23 kg, his already huge spleen continues to grow, he has anemia, shortness of breath. The doctor recommended switching to Momelotinib. Please write, does anyone have experience

I have been trying to decrease my Statin dose and my lipid panel was good except my HDL dropped to 31. I do not have any of the risk factors ( not overweight, don’t smoke ,eat well exercise etc) so I asked google “ Can CLL cause your HDL to droop and the answer was YES. Does anyone have any information

Hi and Happy Holidays, New Year, Christmas, Hanukkah, Kawanzaa (Did I miss anything?). My wife, the well-meaning Vegan in my life and healthy advocate of getting rid of diabetes in the world (a wonderful lofty goal even if she gets only a few converts amongst our family and friends), read about a

My 76 yr.old husband has been diagnosed with this and soon will have to start treatment with Hydroxyurea. He had no symptoms and the diagnosis was found after random blood tests. I am very concerned how this drug will affect him particularly where driving is concerned as we live an hrs drive from our

Good day! My husband has post-polycythemic myelofibrosis. Since 2015 he has been taking ruxolitinib. Over the past year he has lost 20 kg, he has anemia and thrombocytopenia. The doctor recommended switching to Momelotinib. Maybe someone has the same diagnosis and is taking Momelotinib?

With my now intense interest in the FDA approval process for untreatable conditions I was curious on that for Rux. It had an extraordinary fast approval. Its phase 1 trial started in 2007, just two years after the discovery of the Jak2 mutation. Best I can tell its R&D started 2006 and it was approved

I am taking hydroxyurea for my pv. From what I have read since I joined the group, there doesn't seem to be a way of confirming early the onset of myelofibrosis other than having regular bone marrow biopsies, which would be extremely expensive. For some people it seems the symptoms of myelofibrosis

I posted before on acquiring toxic levels of vit B6. https://healthunlocked.com/mpnvoice/posts/151206700/high-b6-level B6 is unique among the B's in its potential neuro hazard at high levels. It usually reverts upon quitting but not always and it can take months. Only certain pts are prone to

Thanks to everyone who responded to my previous post on Progression. Since then I have had my BMB and the worst has been confirmed. Not only have I progressed to Post PV-MF, 1+ to 2+ in some places, but I am in accelerated blast phase at 10%. I have had irradiated blood transfusion last week as my hbg

can jakafi cause lower sodium, chloride and sugar?anyone have this.?

Hi, I'm Jak2+ with P-Vera and 10+ yrs on Jakafi - basically since it was first approved for PV. My recent labs and BMB results no longer fit neatly with PV and would be consistent with transition to MF: hypocellular marrow, anemia, WBC production abnormalities, increased platelets counts (450-550

AJ1-11095 is a novel orally bioavailable small molecule type II non-covalent tyrosine kinase inhibitor that binds both the active and inactive conformations of JAK2 and prevents heterodimerization with JAK1 and TYK2, overcoming a common mechanism of clonal persistence and drug resistance to type I inhibitors

I'm feeling really confused. I was diagnosed with secondary PV 14+ years ago. Very long story short; listening to and acting upon amazing support and advice at the MPN Voice conference in Liverpool this September, I contacted Dr T S at The Christie hospital and had an initial appointment with him

It's been a while since I posted, so I thought I'd share my recent blood work and other updates. Health-wise, things have been good overall, but I continue to have days where I feel completely drained—like a zombie has sucked all the energy out of me. The fatigue hits especially hard mid-day. Still working

 »The authors focus on improved blood count control, rates of thromboembolic events, symptom improvement, and markers of disease modification such as reduction of JAK2V617F allele burden in patients treated with ruxolitinib. They also discuss the well-characterized safety profile of ruxolitinib regarding

https://med.stanford.edu/cancer/about/news/fast-track.html « The fast-track clinical trial is a phase I, first-in-human study evaluating a drug called INCB160058. This drug inhibits only the JAK2 V617F mutation without targeting the normal JAK2 gene. The study protocol initially evaluates drug tolerability

I have PV. I take Ruxolitinib and feel very well now. I do sometimes get night time leg cramps though and have heard that vitamin K may help with them. Does anyone know whether it is ok to take this supplement?