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BTK Inhibitor Therapy for CLL: An International Perspective - Stephan Stilgenbauer, MD
This led to the development of the second-generation BTK inhibitors
acalabrutinib
and zanubrutinib. - Reduced AEs With Second-Generation BTK Inhibitors Head-to-head, randomized clinical trials have compared ibrutinib with
acalabrutinib
and ibrutinib with zanubrutinib.
This led to the development of the second-generation BTK inhibitors
acalabrutinib
and zanubrutinib. - Reduced AEs With Second-Generation BTK Inhibitors Head-to-head, randomized clinical trials have compared ibrutinib with
acalabrutinib
and ibrutinib with zanubrutinib.
lankisterguy
Volunteer
in
CLL Support
1 year ago
Ventoclax&Obinutuzumab or Zanibrutinib&Acalabrutinib
51 years old have been on watch and wait three years. Only reasons to start treatment now seem to be hemoglobin around 10 and after bone marrow recently done I believe about 70% CLL found. Unmutated. Good health outside of cll. My two questions are first what are the chances of serious side effects
51 years old have been on watch and wait three years. Only reasons to start treatment now seem to be hemoglobin around 10 and after bone marrow recently done I believe about 70% CLL found. Unmutated. Good health outside of cll. My two questions are first what are the chances of serious side effects
Bryanb
in
CLL Support
10 months ago
Best Treatment for CLL
Is Zanubrutinib a better treatment than
Acalabrutinib
for CLL because it is the newest approved version for BTK drugs.
Is Zanubrutinib a better treatment than
Acalabrutinib
for CLL because it is the newest approved version for BTK drugs.
Rrriver
in
CLL Support
1 year ago
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What shall i do??
Since previous week,
acalabrutinib
is available in the Netherlands,possibly together with venetoclax. That seems much better to me. Can i refuse FCR, and ask for
Acalabrutinib
, or follow the doctor’s advice??
Since previous week,
acalabrutinib
is available in the Netherlands,possibly together with venetoclax. That seems much better to me. Can i refuse FCR, and ask for
Acalabrutinib
, or follow the doctor’s advice??
Renefaassen
in
CLL Support
1 year ago
Acalabrutinib and headaches
I started taking
acalabrutinib
in December last year. All went well for the first couple of weeks. However for the last 6 weeks I have been getting severe headaches from very early in the morning - usually around 1am - which can last for more than 6 hours. Pain relief doesn’t do any good at all.
I started taking
acalabrutinib
in December last year. All went well for the first couple of weeks. However for the last 6 weeks I have been getting severe headaches from very early in the morning - usually around 1am - which can last for more than 6 hours. Pain relief doesn’t do any good at all.
tpbholm
in
Leukaemia Support
1 year ago
Acupuncture and CLL?
Hi , everyone, I'm interested to hear if anyone has tried acupuncture while on treatment for CLL (specifically while on
Acalabrutinib
)?
Hi , everyone, I'm interested to hear if anyone has tried acupuncture while on treatment for CLL (specifically while on
Acalabrutinib
)?
OaktownA
in
CLL Support
10 months ago
Calquence & Mole Removal ?
One doctor said I don't have to stop Calquence (
acalabrutinib
) for this and another said I have to stop for FIVE DAYS pre- and post-procedure. The latter seems excessive. I once stopped for 7 days pre and post major surgery (removal of ovary and fallopian tubes) but this mole removal is minor.
One doctor said I don't have to stop Calquence (
acalabrutinib
) for this and another said I have to stop for FIVE DAYS pre- and post-procedure. The latter seems excessive. I once stopped for 7 days pre and post major surgery (removal of ovary and fallopian tubes) but this mole removal is minor.
Amberesque
in
CLL Support
10 months ago
Reaction to Venetoclax?
He was on W&W until he started
Acalabrutinib
in January 2022. His WBC went down almost immediately. All was well until it wasn't.
He was on W&W until he started
Acalabrutinib
in January 2022. His WBC went down almost immediately. All was well until it wasn't.
keikikumu
in
CLL Support
1 year ago
Relapsed CLL: New Approaches Prolong Survival
Glück added that "
acalabrutinib
and zanubrutinib have demonstrated strong efficacy and safety. When patients no longer respond to these drugs, the addition of VX is crucial.
Glück added that "
acalabrutinib
and zanubrutinib have demonstrated strong efficacy and safety. When patients no longer respond to these drugs, the addition of VX is crucial.
Jm954
Administrator
in
CLL Support
1 year ago
Venetoclax Consolidation Achieves Durable Off-Treatment Remissions in Patient with High Risk CLL Who Have Been on Ibrutinib More Than a Year
A second cohort restricted to 45 high-risk pts with TP53abnormalities or complex karyotype is accruing and there are plans to also include patients treated with
acalabrutinib
."[/i] From ASH Program: Oral and Poster Abstracts Type: Oral Session: 642.
A second cohort restricted to 45 high-risk pts with TP53abnormalities or complex karyotype is accruing and there are plans to also include patients treated with
acalabrutinib
."[/i] From ASH Program: Oral and Poster Abstracts Type: Oral Session: 642.
Jm954
Administrator
in
CLL Support
1 year ago
1.5 million atrial fibrillation cases may be undiagnosed in US (prevalence estimate of 11%)
While that risk is lower with the second generation approved drugs
acalabrutinib
and zanubrutinib, [u]it's still higher than if you were not taking the drug[/u].
While that risk is lower with the second generation approved drugs
acalabrutinib
and zanubrutinib, [u]it's still higher than if you were not taking the drug[/u].
AussieNeil
Partner
in
CLL Support
1 year ago
Iron Levels with CLL
I also started taking
acalabrutinib
in May. I see a local doctor who didn't seem too concerned and I also see a doc in Cincinnati that says low iron is not normal with CLL/
acalabrutinib
, so he wants me to have an upper GI and colonoscopy. My last colonoscopy was in 2017 and they found no issues.
I also started taking
acalabrutinib
in May. I see a local doctor who didn't seem too concerned and I also see a doc in Cincinnati that says low iron is not normal with CLL/
acalabrutinib
, so he wants me to have an upper GI and colonoscopy. My last colonoscopy was in 2017 and they found no issues.
susq9948
in
CLL Support
1 year ago
One and Done?? Next up!
Quickly, I was started prematurely on
acalabrutinib
in Oct 2022 by a Dr in North Carolina where we spend our summers. Would never of happened if I hadn't gotten Covid in July.
Quickly, I was started prematurely on
acalabrutinib
in Oct 2022 by a Dr in North Carolina where we spend our summers. Would never of happened if I hadn't gotten Covid in July.
Rico49
in
CLL Support
1 year ago
Results on triple combination (A+V+O) for high risk patients -with-chronic-lymphocytic-leukemia-or-small-lymphocytic-lymphoma-cll
The Bottom Line: In this ongoing trial, the triple combination therapy using
acalabrutinib
, venetoclax, and obinutuzumab is highly active.
The Bottom Line: In this ongoing trial, the triple combination therapy using
acalabrutinib
, venetoclax, and obinutuzumab is highly active.
spi3
in
CLL Support
1 year ago
4 weeks into starting acalabrutinib
I have my next Dr appt in a few days so hoping for more good results Thank God for
Acalabrutinib
.
I have my next Dr appt in a few days so hoping for more good results Thank God for
Acalabrutinib
.
Rrriver
in
CLL Support
1 year ago
One Year Anniversary on Acalabrutinib (Calquence)
I have reached my one year anniversary being on
Acalabrutinib
!…..how quickly that year has gone 😅. I’m so happy to report that my most recent bloodwork taken a few weeks ago showed that all of my hematology and chemistry counts were within normal limits…..first time in many years!! 👏👏.
I have reached my one year anniversary being on
Acalabrutinib
!…..how quickly that year has gone 😅. I’m so happy to report that my most recent bloodwork taken a few weeks ago showed that all of my hematology and chemistry counts were within normal limits…..first time in many years!! 👏👏.
MorganNL
in
CLL Support
1 year ago
Prophylactics
Hi I have been on
Acalabrutinib
for two weeks now along with prophylactics, one being Co trimoxazole , which I seemed to react to. I have now been offered Pentamidine, which I have read up on and don’t like the sound of plus it does not sound as if it protects as well.
Hi I have been on
Acalabrutinib
for two weeks now along with prophylactics, one being Co trimoxazole , which I seemed to react to. I have now been offered Pentamidine, which I have read up on and don’t like the sound of plus it does not sound as if it protects as well.
Sunshine2422
in
CLL Support
1 year ago
Hives like sores on scalp
I started
acalabrutinib
in May and only taking one dose per day. A few weeks ago I started with sores on my scalp that itch. I've switched certain products to see if that helps but it doesn't appear to affect it. Could this be my body reacting the meds? Has anyone else had this issue? Thanks
I started
acalabrutinib
in May and only taking one dose per day. A few weeks ago I started with sores on my scalp that itch. I've switched certain products to see if that helps but it doesn't appear to affect it. Could this be my body reacting the meds? Has anyone else had this issue? Thanks
susq9948
in
CLL Support
1 year ago
Drug rash
I am three months on
Acalabrutinib
an take aciclovir (antiviral) Have developed rash on ankles any oneelse experienced this.
I am three months on
Acalabrutinib
an take aciclovir (antiviral) Have developed rash on ankles any oneelse experienced this.
Simpomo
in
CLL Support
1 year ago
hypertension and stroke on acalabrutinib
I had high blood pressure on
acalabrutinib
and a stroke two weeks ago. anybody in community experienced this terrible side effects?
I had high blood pressure on
acalabrutinib
and a stroke two weeks ago. anybody in community experienced this terrible side effects?
Belkin123
in
CLL Support
1 year ago
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