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Abiraterone
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Abiraterone / Docetaxel
-Patrick http://www.onclive.com/conference-coverage/cfs-2017/comparing-
abiraterone
-and-docetaxel-in-prostate-cancer-treatment
-Patrick http://www.onclive.com/conference-coverage/cfs-2017/comparing-
abiraterone
-and-docetaxel-in-prostate-cancer-treatment
pjoshea13
in
Advanced Prostate Cancer
7 years ago
Supraphysiologic Testosterone Therapy for PCa. BAT.
"BAT is currently being tested in a large (n = 180) randomized trial (NCT02286921; TRANSFORMER) in asymptomatic mCRPC patients who have failed on
abiraterone
. In this study, BAT is being compared with ENZ with a primary end point of progression-free survival (PFS).
"BAT is currently being tested in a large (n = 180) randomized trial (NCT02286921; TRANSFORMER) in asymptomatic mCRPC patients who have failed on
abiraterone
. In this study, BAT is being compared with ENZ with a primary end point of progression-free survival (PFS).
pjoshea13
in
Advanced Prostate Cancer
7 years ago
Cabazitaxel, Abiraterone or Enzalutamide?
I have been given 3 options which are Cabazitaxel,
Abiraterone
or Enzalutamide!
I have been given 3 options which are Cabazitaxel,
Abiraterone
or Enzalutamide!
andysb
in
Advanced Prostate Cancer
7 years ago
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Xtandi (Enzalutamide) & Drug-Drug Interaction.
Author information Abstract PURPOSE: In ongoing clinical research on metastatic castration-resistant prostate cancer (mCRPC) treatment, the potential enhanced efficacy of the combination of taxanes with AR-targeted agents, i.e. enzalutamide and
abiraterone
, is currently being explored.
Author information Abstract PURPOSE: In ongoing clinical research on metastatic castration-resistant prostate cancer (mCRPC) treatment, the potential enhanced efficacy of the combination of taxanes with AR-targeted agents, i.e. enzalutamide and
abiraterone
, is currently being explored.
pjoshea13
in
Advanced Prostate Cancer
7 years ago
Xofigo Timing.
Studies are ongoing with higher-dose or extended-dose radium-223 regimens (NCT02023697) and combination with other agents (NCT02034552 [radium-223 +
abiraterone
or enzalutamide], NCT02043678 [radium-223 +
abiraterone
+ prednisone/prednisolone], NCT01106353 [radium-223 + docetaxel]).
Studies are ongoing with higher-dose or extended-dose radium-223 regimens (NCT02023697) and combination with other agents (NCT02034552 [radium-223 +
abiraterone
or enzalutamide], NCT02043678 [radium-223 +
abiraterone
+ prednisone/prednisolone], NCT01106353 [radium-223 + docetaxel]).
pjoshea13
in
Advanced Prostate Cancer
7 years ago
Adt + abiraterone. Adding docetraxel? Adding metformin ?
I am afraid the chemio could be too hard on him and am hoping the
abiraterone
can be enough for now. I would love to get your advice on this. On a side note, it seems adding Metformin is a no brainer with his adt treatment.
I am afraid the chemio could be too hard on him and am hoping the
abiraterone
can be enough for now. I would love to get your advice on this. On a side note, it seems adding Metformin is a no brainer with his adt treatment.
Abouziz
in
Advanced Prostate Cancer
7 years ago
Do we need a revision of advanced prostate cancer overall survival statistics?
we're all familiar with the often stated figures of only 30% of men with advanced pc will survive 5 years or that median life expectancy is generally 3-5 years, however I wonder given the recent developments in treatment - not least the change in the standard of care to introduce early docetaxel and/or
abiraterone
we're all familiar with the often stated figures of only 30% of men with advanced pc will survive 5 years or that median life expectancy is generally 3-5 years, however I wonder given the recent developments in treatment - not least the change in the standard of care to introduce early docetaxel and/or
abiraterone
Jlcwonderboy
in
Advanced Prostate Cancer
7 years ago
Abiraterone & Milk Thistle not a good combo
Word back: milk thistle might inhibit the metabolism of
abiraterone
, meaning it could lead to an increased concentration of the drug in my system, putting me at risk for more or increased side effects. Suffice it to say, I have stopped the milk thistle.
Word back: milk thistle might inhibit the metabolism of
abiraterone
, meaning it could lead to an increased concentration of the drug in my system, putting me at risk for more or increased side effects. Suffice it to say, I have stopped the milk thistle.
ronton2
in
Advanced Prostate Cancer
7 years ago
Abiraterone acetate with/out LHRH therapy.
"... the proven increase of luteinizing hormone levels after LHRH withdrawal, which is even further increased by
abiraterone
, may counteract the effects of
abiraterone
by the induction of enzymes of steroidogenesis."
"... the proven increase of luteinizing hormone levels after LHRH withdrawal, which is even further increased by
abiraterone
, may counteract the effects of
abiraterone
by the induction of enzymes of steroidogenesis."
pjoshea13
in
Advanced Prostate Cancer
7 years ago
Testing for BRCA Mutations.
He works in the clinical drug development Phase I trials program at the Royal Marsden NHS Foundation Trust Hospital, and he has been involved in the early clinical development of more than 100 novel agents—many of which are now approved drugs, including
abiraterone
, MDV3100 and cabazitaxel for advanced
He works in the clinical drug development Phase I trials program at the Royal Marsden NHS Foundation Trust Hospital, and he has been involved in the early clinical development of more than 100 novel agents—many of which are now approved drugs, including
abiraterone
, MDV3100 and cabazitaxel for advanced
pjoshea13
in
Advanced Prostate Cancer
7 years ago
Looks like I've moved into castrate resistance territory. What next?
I know
Abiraterone
and enzalutamide are in my future, but I'm reaching out for thoughts and comments.
I know
Abiraterone
and enzalutamide are in my future, but I'm reaching out for thoughts and comments.
paulofaus
in
Advanced Prostate Cancer
7 years ago
Bipolar androgen therapy in men with metastatic castration-resistant prostate cancer after progression on enzalutamide.
These data represent the final analysis for the post-enzalutamide cohort, while two additional cohorts (post-
abiraterone
and newly castration-resistant prostate cancer) are ongoing. The trial is registered with ClinicalTrials.gov, number NCT02090114.
These data represent the final analysis for the post-enzalutamide cohort, while two additional cohorts (post-
abiraterone
and newly castration-resistant prostate cancer) are ongoing. The trial is registered with ClinicalTrials.gov, number NCT02090114.
pjoshea13
in
Advanced Prostate Cancer
7 years ago
Re-treatment with radium-223.
Concomitant agents were allowed at investigator discretion, excluding chemotherapy and initiation of new
abiraterone
or enzalutamide.
Concomitant agents were allowed at investigator discretion, excluding chemotherapy and initiation of new
abiraterone
or enzalutamide.
pjoshea13
in
Advanced Prostate Cancer
7 years ago
STAMPEDE Trial: Adding Abiraterone Acetate or Docetaxel Plus Prednisone to ADT.
Failure–free and progression-free survival clearly favoured SOC+
abiraterone
+prednisone, and with less certainty, metastasis-free survival favoured SOC+
abiraterone
+prednisone.
Failure–free and progression-free survival clearly favoured SOC+
abiraterone
+prednisone, and with less certainty, metastasis-free survival favoured SOC+
abiraterone
+prednisone.
pjoshea13
in
Advanced Prostate Cancer
7 years ago
New AR-V7 Test. German; simpler; cheaper(?).
Moreover, it can also determine whether or not the tumor is resistant to treatment with
abiraterone
and enzalutamide.
Moreover, it can also determine whether or not the tumor is resistant to treatment with
abiraterone
and enzalutamide.
pjoshea13
in
Advanced Prostate Cancer
7 years ago
Advanced Metastatic Prostate Cancer Survivor
PSA after 7 months of treatment on the stampede trials program using
Abiraterone
/Prostap is less than 0.1ng/ml. Currently, my cancer is managed very well indeed...
PSA after 7 months of treatment on the stampede trials program using
Abiraterone
/Prostap is less than 0.1ng/ml. Currently, my cancer is managed very well indeed...
alsam
in
Advanced Prostate Cancer
7 years ago
Dad's first Oncology appointment
Also I asked my Dad to raise the possibility of early use of
abiraterone
/zytiga as we have all seen the recent groundbreaking results from the STAMPEDE trial about the benefits. Apparently the oncologist said that NICE had not granted a licence for
abiraterone
yet and so this wasn't possible.
Also I asked my Dad to raise the possibility of early use of
abiraterone
/zytiga as we have all seen the recent groundbreaking results from the STAMPEDE trial about the benefits. Apparently the oncologist said that NICE had not granted a licence for
abiraterone
yet and so this wasn't possible.
Jlcwonderboy
in
Advanced Prostate Cancer
7 years ago
Olaparib & Durvalumab ... ASCO 2017
All were treated with enzalutamide (35%),
abiraterone
(6%) or both (59%). Most were ECOG status 0-1. 63% had bony and visceral metastatic disease.
All were treated with enzalutamide (35%),
abiraterone
(6%) or both (59%). Most were ECOG status 0-1. 63% had bony and visceral metastatic disease.
pjoshea13
in
Advanced Prostate Cancer
7 years ago
Zytiga + Statins + CRPC
"We assessed the effects of statin use in patients with advanced prostate cancer receiving
abiraterone
. Patients treated with a statin plus
abiraterone
appeared to live longer than those treated with
abiraterone
only.
"We assessed the effects of statin use in patients with advanced prostate cancer receiving
abiraterone
. Patients treated with a statin plus
abiraterone
appeared to live longer than those treated with
abiraterone
only.
pjoshea13
in
Advanced Prostate Cancer
7 years ago
AR-V7 Tests - Video
So, the usefulness of the test really becomes important after
abiraterone
or enzalutamide particularly. The second AR-V7 test, which was developed at Johns Hopkins by Dr. Luo’s lab, is an RNA-based expression.
So, the usefulness of the test really becomes important after
abiraterone
or enzalutamide particularly. The second AR-V7 test, which was developed at Johns Hopkins by Dr. Luo’s lab, is an RNA-based expression.
pjoshea13
in
Advanced Prostate Cancer
7 years ago
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