abiraterone

[Sergio1]

hi all

a short question

i started abiraterone + prednisone in january 17

but after some months or years ?

chemio?

mha..........

by

[YostConner]

Well, hopefully you'll get benefit from abiraterone for a long time. I'm still getting some benefit after 32 months. There are several options after that: chemo, enzalutamide, xofigo, provenge, trials (combinations of drugs, megadoses of T).

[ctarleton]

Hello Sergio,

Ciao Sergio,

Here are some treatment options on a web page translated by Google.

Ecco alcune opzioni di trattamento su una pagina web tradotta da

translate.google.com/transl...

Charles

[Dr_WHO]

You should look up the results from the Stampede trial. It showed great synergistic effect from adding Lupron to Zytiga.

nejm.org/doi/full/10.1056/N...

[TommyTV]

I've been on the Stampede trial for 5.5 years. PSA at diagnosis was >600. Currently <0.1. Abiraterone has worked incredibly well for me.

[Stumpgirl in reply to TommyTV]

Hi. My dad was recently diagnosed and just got his first Lupron shot. His MO has in his notes that my dad might try Abieraterone versus Doxetacel. May I ask if your cancer had spread to the bone and if you think results might change accordingly ? Thanks

[Dr_WHO in reply to Stumpgirl]

Abieraterone has fewer side effects. You could keep Doxetacel in your back pocket if needed later

[Stumpgirl in reply to Dr_WHO]

Thank you for the reply. Being a novice, my understanding is that Abiraterone is a second line treatment normally which is now being used in combination with hormone therapy and can give a longer period of success. Do you think there is a risk in using a second line drug first or in delaying the time to chemo if age is a factor? There are so many unknowns.

[Dr_WHO in reply to Stumpgirl]

This month they have published the results of the Stampede trial done in the U.K. In short the results indicate significant reductions in death rates and delay if PSA rising using a mixture of Lupron with one of the secondary treatments. It was for that reason my medical oncologist added Zytiga in addition to Lupron. Listed below is a reference.

nejm.org/doi/full/10.1056/N...

[TommyTV in reply to Stumpgirl]

Hi

Yes, I have multiple mets. Skull, shoulder, two ribs, pelvis and both femurs. I take three drugs - a Zoladex implant every 12 weeks, Abiraterone and Predisolone daily.

The Stampede trial here in the U.K. has proven that the combination of Zoladex and Abiraterone taken early resulted in 38% less deaths, and longer survival times. Previously, Abiraterone was an end of life drug, but it now appears to slow the cancers progression to CRPC.

Given my initial PSA, I am really happy I got to take part in this trial. I'm still well, I've got all the usual issues with having no testosterone, but I'm over the worst.

I did get addicted to opiate pain killers which I was taking to quieten my legs down at night (my femurs are quite badly damaged by the PCa), but I went 'cold turkey' about two months ago, and I've come to realise the opiates were causing more problems, as the withdrawal symptoms were encroaching earlier into each day, making my legs even worse.

Abiraterone doesn't suit everyone, it can impact on your liver function, blood pressure and potassium levels. Personally, as I've been thoroughly checked (full bloods and blood pressure) every 4 weeks for the last 5.5 years, I've had none of those issues.

All this is free here in the U.K., so financial concerns don't enter the decision what to take.

Good luck for the future, we all seem to be living longer with this cancer than 10 years ago.

Cheers

Martin

[Sergio1 in reply to Stumpgirl]

of course. i ave two metastases at the vertebra l1 and d12. In January I started abiraterone and zometa more naturally prednisone and decapeptil. I look at the next pet I'm going to do in September. For now I'm pretty good apart from a slight nausea. by

[Stumpgirl]

Thank you very much. I wish you well on this very challenging journey

[MelaniePaul]

Hi.

My husband has been on Aberaterone in combination with a hormone treatment injection every three months since June 2014 and he is still doing very well.

We are not thinking about Chemo now although this may be further down the line, but there are other options too.

I would say the strongest side/effect we are battling with at the moment is lack of energy, which may well be because of the low Testosterone levels.

Mel.