Neutrophilic dermatoses, including Sweet's syndrome, have previously been recognized in antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis. Eosinophilic granulomatosis with polyangiitis (EGPA) is an ANCA-associated vasculitis. Vasculitis is inflammation of the blood vessels. SEE COMMENTS FOR INFO ON THESE CONDITIONS.
This is a case of a 46-year-old man with asthma who developed a fever, shortness of breath, difficulty moving about, and a severe rash. Skin lesions were on his scalp. Blood tests showed a raised white cell count, including a high eosinophil count (absolute eosinophil count 7.75), high-titer myeloperoxidase antibody (MPO-ANCA), and positive perinuclear ANCA (p-ANCA). CT scan demonstrated large subpleural opacities (lung involvement). Nerve conduction studies were consistent with peripheral neuropathy.
The findings were consistent with EGPA, but the rash wasn't typical of this condition - often subcutaneous nodules with eosinophilic vasculitis. The biopsy showed dense neutrophilic infiltrate with dermal oedema indicating Sweet's syndrome (lots of white blood cells called neutrophils in the tissue; fluid leaking into dermis; normally an absence of vasculitis).
The patient’s symptoms improved with intravenous methylprednisolone, followed by oral prednisone and rituximab.
Does anyone suffering with the fatigue, light headed, aches and insomnia that goes with sweet syndrome? 
Health unlocked newbie
Newly Diagnosed and Struggling