Sweet’s syndrome is an autoinflammatory (not autoimmune) condition and form of neutrophilic dermatosis. Autoinflammatory conditions are rare conditions caused by errors in the innate immune system. Neutrophilic dermatoses are conditions affecting the skin that occur as a result of lots of white blood cells called neutrophils accumulating in the tissues, and can sometimes be a sign of underlying illness.
Hope Shell567 doesn't mind me linking this support for people too
Changing Faces help with skin camouflage products are creams and powders that can be used to reduce the appearance of a mark, scar or skin condition. Many people with a visible difference can struggle with social anxiety and low confidence, especially as they can experience staring, comments, or unwanted attention.
My partner was diagnosed with sweet syndrome 8 years ago after being told that he had chicken pox 5 times it wasnt until we had a locum doctor paying us a home visit because my partner couldnt walk due to swelling of his legs and admitted him to hospital for tests where they diagnosed him with sweet syndrome.the most annoying part is our regular doctors have no idea what it is. Perhaps i should show them this site
Shell567AdministratorSweet's Syndrome UK in reply to DayzeeB
Hi Dayzee B,
Hope your partner's SS is now well managed/has settled down. I was initially misdiagnosed with impetigo. I was prescribed antibiotics for months and months, but despite my obvious deterioration, my doctors refused to accept that there might be something more serious going on. By the time they accepted it wasn't impetigo, I was in a terrible state.
Very interesting especially the eyes. Bryan just had cataract surgery. He had 2 cataracts. One on top and one underneath the lens. The Doctor noted that his eye looked liked it had had something traumatic happen to it. We asked if it could possibly associated with SS. He had never heard of SS and googled it while we were sitting there. We attempted to explain what it was but complicated. The doctor will be doing his other eye on Thursday and we will be very interested in find out what that eye will look like. I think I will provide him with a copy of this info. He will be interested in knowing. Thank you.
"SS ocular involvements are diverse including periorbital and orbital inflammation, dacryoadenitis, conjunctivitis, episcleritis, scleritis, limbal nodules, peripheral ulcerative keratitis, iritis, glaucoma, panuveitis, retinal vasculitis, and choroiditis." em-consulte.com/en/article/...
Interleukin-17E, inducible nitric oxide synthase and arginase 1 as new biomarkers in the identification of neutrophilic dermatoses, OCT 2021. onlinelibrary.wiley.com/doi...
"We found that SS is characterized by high expression of IL-17E and iNOS in the epidermis, while PG exhibits low expression."
SS: Sweet's syndrome.
PG: Pyoderma gangrenosum.
IL-17E: Interleukin 17.
iNOS: Inducible nitric oxide synthase. iNOS is an enzyme which is encoded by the NOS2 gene in humans and mice.
Neutrophilic Dermatosis and Management Strategies for the Inpatient Dermatologist, JULY 2022. link.springer.com/article/1...
SWEET’S SYNDROME.
“Work-up and Diagnosis.
Laboratory Studies/Serological Tests.
Laboratory investigation should include a complete blood count with differential. Although non-specific, peripheral leukocytosis with neutrophilia and an elevated ESR/C-reactive protein (CRP) is frequently seen [19]. Elevated serum levels of antineutrophil cytoplasmic antibody (ANCA) have also been reported, though it has limited evidence as a marker of disease [32]. Evaluation for pregnancy should be done in women of childbearing age.
Biopsy.
Two 4-mm punch biopsies are sufficient for histological evaluation and tissue culture in order to exclude infection. When patients present with primarily subcutaneous nodules, excisional biopsy may be preferred.
Evaluation for Malignancy or Other Associated Conditions.
In the absence of other explanations and presence of concerning constitutional symptoms, malignancy work-up can be considered in the inpatient or outpatient setting. Of note, any abnormalities in the CBC count should prompt consideration of bone marrow biopsy. Beginning with age-appropriate screenings followed by work-up for the most commonly associated malignancies is recommended. Evaluation for autoimmune disorders or inflammatory bowel disease (IBD) can be considered based on clinical suspicion, though it may be more appropriate in the outpatient setting.”
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