Reflectance Confocal Microscopy of Sweet Syndrome, 2025. pmc.ncbi.nlm.nih.gov/articl...
Skin biopsy is needed to diagnose Sweet's syndrome. It most commonly shows dense neutrophilic infiltrate (lots of white blood cells called neutrophils in the skin), dermal oedema (fluid in the dermal skin layer), and an absence of vasculitis (no swelling of the small blood vessels).
Reflectance confocal microscopy (RCM) is a non-invasive imaging technique.
"It has been shown that RCM is efficient in psoriasis in monitoring neutrophils which appear as bright round to oval cells surrounded by a dark acellular area. Edema appears as dark homogenous area just below the epidermis."
In Sweet's syndrome, RCM is able to detect dense neutrophilic infiltrate and dermal oedema, but unable to determine the presence or absence of vasculitis.
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