I have only been diagnosed about 2 years but like many people I think I have had the condition for many years before. Since being put on slow release Adalat and a yearly October iv of Illoprost I have to say the worse aspects eg ulcerated toes have all calmed down (plus I think this mild UK winter had helped enermously).. I do however have trouble with my thighs, they are like leaden lumps which I have to lift into the car which is when I notice it the most. I have read that the Adalat can cause muscular problems and I don't remember having this prior to my diagnosis. Other than that I take medication for stomach accidity. I just wondered if anyone had any thoughts?