Starting olaparib parp inhibitor in month. Anyone else taking this.

[Beachperson]

Just finished with month eighth of carbo and doxil. Second cycle of chemo after coming out of remission last July. Stage 4 diagnosed nov 2016.

Is anyone else on this drug? Oncologist wants to start me at highest 300 dose. I have no side effects with chemo other than moderate fatigue and low platelets but I worry about the nausea and reduced quality of life. I dont have brca mutation but doctor says I am still a candidate for this. First some reason I am more concerned about this drug than chemo. I am 66 and treated at city of hope in Los Angeles. Thanks all

[Lind58]

Best of luck, I hope this brings you in remission for a long time.

[Beachperson in reply to Lind58]

Thank you. Hoping for a wonderful California summer

[SurvivorSusan]

Hi, I am taking Olaparib, 300 mg. Have been for 5 months. I had stage 4 ovarian cancer in 2012, treated with chemo and surgery. In remission for 5.5 years. It came back this year and I went on Olaparib. I am on a clinical trial for those who have BRCA, which I do. After 4 months the tumors had shrunk by 60% and my CA 125 is normal. I am so deliriously happy that I don't have to do chemo!

Side effects from Olaparib: In the beginning I was very tired, took a nap every day and had a lot of gas and intestinal upset - not nausea, just discomfort. My sweat smelled really bad. My taste is off. There are many things I don't want to eat and lots of things don't taste as good as they used to. So I'm eating a lot of the wrong things and gaining weight. Now, 5 months in, I have much more energy. Only take a nap about once a week (or twice); the gas is gone, sweat is normal, but my taste is still depressed. I'm going to have to figure out an eating plan that I can manage.

Long and short of it: I wouldn't be afraid of this drug. You can always stop it, if the side effects are too bad. They should follow you closely. I had weekly blood tests for the first 6 weeks or so, and now monthly.

[Beachperson in reply to SurvivorSusan]

Thank you so much for replying. Yes my appetite for food has changed so well. I'll be aware of that.

[SurvivorSusan in reply to Beachperson]

You're welcome.

[Nlehrer in reply to SurvivorSusan]

Hi, how are you doing now? I am new to this web site and came across your post. Im 42 dx with stage iv ov ca last january, went thru chemo and debulking and total hyst sx. I have been NED. Dr says its because Im BRCA postitive. I was triple negative breast cancer in 09 when i was 26. just celebrated my 15yrs being cancer free and surprise its not gas its cancer. I have been on lynparza for about 6 months now. how long did it keep you in remission for? TY

[Archeveritas]

How did you realize your cancer had returned?

[Beachperson in reply to Archeveritas]

I w as s being monitored and the ca125 increased

[jloreth]

Hello,

I have been on it for 16 months, I am BRCA negatitive. My side effects have been minimal, I have an increased sensitivity to certain food; the first 1-2 weeks felt a little bit nauseous. I would not be afraid of this drug. I was monitored weekly at first, then monthly and now bi-monthly.

Keep us posted.

[Beachperson in reply to jloreth]

Thank you so much. So happy for your progress with it

[KCWM]

Hi I too was very afraid of the side affects. Two months ago I was started on 100 mg for the first month now I am in the middle of the second month on 200 MG. My doctor wants to up it to 300 in a month. I have only had a little nauseous feeling in the morning for a few minutes until I would eat something. Also I am constipated, but I can deal with that.

I just hope that it will keep the cancer away. So I would not worry about taking it. I don’t think that you get that many side effects from it.

[Beachperson in reply to KCWM]

Thank you so much!

[Nlehrer]

Hi there, how are you doing now. I am new to this site and saw your post regarding Olaparib. I am on that right now. I wanted to reach out and see how long it kept you in remission for.