I have been capecitabine 500 mg tablet X 2

[Bikeriding]

I am a 62-year-old woman with a history of metastatic ER

positive, HER-2/neu negative breast cancer with metastasis to bone as

well as adenopathy to the right supraclavicular area. Right axillary

biopsy demonstrated ER positive, HER-2/neu 2+, FISH negative disease. Previous

treatment with FEC docetaxel completed August 2009, tamoxifen 2009 to

2012, oophorectomy 2013, letrozole 2012 to 2017.

CURRENT TREATMENT:

1. Letrozole since March 31, 2020.

2. Ibrance dose reduced to 75 mg due to neutropenia.

3. Zoledronic acid every 3 months given aug 2024

4. radiation to spine.

5. Being followed by Dr. Chang from urology for retroperitoneal fibrosis.

6. Capecitabine cycle 22a, started June 2023.

7. Gets bone pain when she get

[Elle713]

I’m 64. HR+HER2- Ibrance/Faslodex for 18 mos. One bine met. Then Orserdu 2 months. Major progression to bones/liver. Trodelvy 6 mos. Stable but uptake increased. Just started Xeloda!

Have you had any improvement? Side effects? I’m on 1000am/1000pm. 7 days on/7 days off.

Not feeling so good. My daughter is getting married in February. I just want to feel well.

Did you start on 500/500? Any tips?

[utahsara in reply to Elle713]

My 72 year old wife who has Stage 4 Met Breast Cancer that has spread to her bones is starting her 5th cycle on Christmas Day, and found with her Pet Scan that all the Bone Cancer is Gone, she is on 3000 mg of Xeloda, 2 weeks on 1 week off. Oncologist visit today said this is great news, as well as her tumor markers dropping 650 points in the last 3 months....but there is No Cure and over time the markers may start to increase and another option as to treatment may be needed. So Far Xeloda has been a God send as to quality of life, cost and extending my wife's life. Hope this helps you and others.

[Elle713 in reply to utahsara]

That is great news and certainly the “best” Christmas Present! We live for those good reports. May I ask - has she had any hand/foot issues or other side effects?

[utahsara in reply to Elle713]

Yes, but only skin darkening on her hands and feet, no blistering, and only a few ( maybe three ) times having a tiny bit of nausea controlled by a 1/4 tab of her nausea medication. She has been on Ibrance, Truqap and Xeloda has worked the best so far by leaps and bounds as to her not having side effects and of course the wonderful scan results. Her Blood counts as to Red & White cells and Hemoglobin are low, but they were low on those other meds I mentioned too. Anemic as to clod hands and feet and we need to shy away from anyone who is sick of course, because of the blood counts. But her eating has improved and no weight loss either. Hope this helps, we have been on this cancer journey now for 7 years and 10 operations.

[Liessie2014 in reply to utahsara]

Aww wow, that’s fantastic news , thank you for sharing , it gives all a nice positive feeling , that’s amazing ❤️

[Bravespirit in reply to utahsara]

Fantastic news! I hope this treatment continues to work for her with minimal side effects from many years.

[Bravespirit in reply to Elle713]

I am 63 diagnosed MBC in November 2023. HR+ HER2- (low +1). I have met to hip, femur, sacrum, V6 vertebrae, and small spot in my lungs.

I began on Ibrance w Faslodex injections. I was only on this treatment for three months as I experienced progression in my sacrum..

My next line of treatment was Orsedu as I have the ESR1 mutation. Well my scans look ed stable. with slight increase in avidity in my Mets, my CA – 15 was increasing approximately 50 points per month (I get monthly blood panels prior to my Zometa infusions), which my oncologist did not like, so after just 3 months on Orsedu, I was changed to XELODA at 4000/4000!!!

I was very nervous to make this change as I had mild if any side effects on my other lines of treatment, and the forums on XELODA were frightening. I am grateful to say that I have had virtually no side effects from this medication, and am just completing my third cycle. I follow all the precautions/protocols, particularly taking the medication with food and keeping my feet and hands well hydrated.

I also pay very close attention to my overall health - Whole foods/good nutrition, gut health, sleep, stress management and as much exercise as my physical imitations allow.

My tumor markers have come down 200 points after just 2 cycles. I am very encouraged. It is a joy to see things move in the right direction.

I hope your symptoms are simply your body adjusting to a new medication and that they subside or become manageable very soon. 🙏

[Elle713 in reply to Bravespirit]

That is a great report! And very encouraging.

4000/daily - wow - that’s a high dose. God Bless!