City of Hope MAST Trail

[hopeoflife]

Hello everyone,

I was very encouraged by the impressive results from this novel cancer-killing virus CF33-hNIS (VAXINIA) clinical trial.

youtube.com/watch?v=k9AUCLi...(Not working as expected?)

I particularly like the fact that there were nearly no toxicity and adverse effects from this innovative approach except some flu-like symptoms which go away after a while. I am now moving onto my 3rd line of treatment, and my body is very beat up by the toxicity and side effects...I would love to explore the opportunity to participate in this study.

May I ask if anyone is currently enrolled in this study, please? Would you be so kind as to share your experience and how to get on this trial please?

Thank you so much in advance for any insights or advice that you could kindly share with me!

April

[Adele_Julia]

likewise !

[Chamisa]

Very interesting. Encouraging.

Here is a link to the trial info sheet. Towards the bottom there is a list of recruiting institutions.

classic.clinicaltrials.gov/...

[Adele_Julia in reply to Chamisa]

thank you for the link !! What I couldn’t find is if it’s for HER2 low patients?

[hopeoflife in reply to Chamisa]

Thank you so much for sharing this! 🙏

[hopeoflife in reply to Chamisa]

Thank you for sharing this link! It is very helpful and much appreciated. ❤️❤️❤️

[gossy29]

I'm also very interested in this trial and have been following it closely for about 18 months. I contacted the trial site nearest me (in Australia) and have talked to the trials co-ordinator. I have sent through bloodwork, biopsy info and scans etc and hope to be eligible if my current treatment fails. I will update here if I have any news

[hopeoflife in reply to gossy29]

Sounds wonderful! Thank you so much for sharing this. I pray that you will be eligible to enroll in the study and it will work miracles on you!!! 🙏💖

[Split in reply to gossy29]

Do you know if this trial is also conducted in Sydney? Do you have a link to Vaxinia trial description which lists the sites in Australia where the trial is/will be conducted. I only found a while ago a ref to Tasman Oncology Research in South Australia being the first hospital approved to conduct these trials with human patients. Thank you!

[gossy29 in reply to Split]

In Australia, it is currently only open in Southport QLD and St Vincent’s hospital in melbourne but I believe they are looking to open more sites in the future. The clinical trials record link is below :

clinicaltrials.gov/study/NC...

[Split in reply to gossy29]

Thank you. Yes, I saw the trial blurb phase I dose escalation, monotherapy or in combo with keytruda, but thought that you have seen ref to more trial sites then the 2 mentioned. Best!

[Godbeforme]

Praise God! This is fascinating! My new mantra is "FIRST let them DO NO HARM"! God bless you and heal us all in Jesus name, amen! <3

[hopeoflife in reply to Godbeforme]

Couldn't agree with you more! I feel that this is the right approach and is the real target therapy unlike what's currently available. May God bless us so that we all get to see the day when we find a way to end this hideous disease once and for all! 🙏🙏🙏

[Godbeforme in reply to hopeoflife]

amen!

[JEE123]

Thank you so much for sharing. Adds a lot of positive energy to my day. I don't think they addressed how this could help people where the cancer is systemic like those of us with bone Mets. It seems more tumor oriented but very encouraging.

[hopeoflife in reply to JEE123]

I am so happy that this helps brighten your day a bit 🥰 My understanding is that the IV arm is investigating the effectiveness of the treatment systematically and the Intra-tumor injection arm is evaluating the effectiveness of the treatment on more localized tumors. I would love to learn more about this trail. But I see great promise with this approach even though they are still in early stages.

[JEE123 in reply to hopeoflife]

Thanks for the clarification. I've just started treatment. De novo diagnosis back in April. Currently stable with Ibrance and Hormone suppressant. I feel good and of course I'm hoping to stay this way as long as possible. It's helpful psychologically to know that there will hopefully be better options for me when the time comes.

[TammyCross]

If this phase of the trial is successful, it would be better to get into the next phase, as Phase 1 tests toxicity.

[hopeoflife in reply to TammyCross]

Thank you so much for your sage advice! 🙏💖