next treatment Doxil

[Lna21]

hello everyone

In July 1st 2022 I enrolled in a clinical trial with AZD (Faslodex in pills) and Capivasertib.

Unfortunately last PET scan is showing progression on my liver.

Options are Everolimus or Abemaciclib and IV chemo: Doxil.

My onc strongly recommends Doxil.

Obviously I am scared of IV chemo and was wondering if you could share your experiences with Doxil with me please.

How efficient was it ? What about side effects ?

Thank you very much !

Helene

[Silver126]

I was on Doxil (in Italy it’s Caelyx) for about five months with no side effects. Ask your onc but this treatment should preserve your hair. I had a very good PET scan after two months, but when it stopped working after three months I had new mets in bones and again in breast (where I was NED for two years) and widespread mets in liver. I wish it worked longer… it’s a good treatment. My blood tests were perfect and I had a much better quality of life than when on Ribociclib.

[13plus in reply to Silver126]

I am somewhat shocked to hear you had no side effects on IV chemo. My experience was the ACT chemo regimen back in 2005 when I was first diagnosed bc and it was tough! Different drugs though so I guess they’re not all bad

[Silver126 in reply to 13plus]

I think that things changed a lot during the years. I suggest you to have a port installed, that’s good for your veins

[13plus in reply to Silver126]

They have changed a lot since then for sure. Even for mets patients. I think of a whole group of friends I had who had bc, starting back around 2008/9, who then later developed mets dx, and many of that group died within less than a decade. They just didn't have the treatment options we have today! It's very humbling

[Lna21 in reply to Silver126]

Hello Silver126

How are you ?

Doxil did not work for me. I did not have many side effects except fatigue and neuropathy in hands and feet. I did not loose my hair.

Which treatment did you start after it please ?

I hope you are doing well.

Helen

[Silver126 in reply to Lna21]

Hi Lna21, after Doxil I started Abraxane and it worked for about 6 months. Now I’m on Trodelvy and I think it’s the one which is giving me less side effects.

[Lna21 in reply to Silver126]

Thank you for your answer. I hope you will be able to enjoy the holidays

[13plus]

I’ve got bone and liver mets which have both progressed this year. I just started Everolimus. I guess your doctor’s suggestion might depend on the status of how big the liver mets are and the function? Like I have several lesions but nothing too big, and the liver function is quite good

[Silver126 in reply to 13plus]

My liver functions were good and I only had three small mets. My onc tried Everolimus and Exemestane before Doxil, but it was the only treatment I tried that didn’t function at all. I hope it works on you, we’re all different!

[13plus in reply to Silver126]

Ah, I'm so sorry it didn't work for you. I know, it's a bit like playing Russian roulette

[Silver126]

Thanks at the moment I’m doing fine, ready for Christmas 🎄