Cancer breakthrough as groundbreaking pill found to ‘kill tumours’

[Kerryd22]

Scientists at a leading US hospital have developed a “cancer-killing pill” that kills solid tumours through “targeted chemotherapy.”

Likened to a “snowstorm that closes a key airline hub, shutting down all flights in and out only in planes carrying cancer cells”, the protein was developed by a research team at the City of Hope, one of the largest cancer research and treatment organisations in the US.

The AOH1996 molecule works by targeting a cancerous variant of PCNA, a protein critical to DNA replication and repair of enlarging tumours.

Developed over the last two decades, it has shown to be effective in preclinical research treating breast, prostate, brain, ovarian, cervical, skin and lung cancers.

The study, published in the journal Cell Chemical Biology, tested the protein across over 70 cancer cell lines. The results noted that AOH1996 selectively killed cancer cells by “disrupting the normal cell reproductive cycle”, with the next stage aiming to further the clinical trial in humans. A stage 1 trial is being run at City of Hope.

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[NPmary]

Exciting news! Thanks for sharing.

[love2golfwell]

That sounds amazing, thank you for sharing this information!

[LDR1]

Wow! Great to hear. Hope the trials go well and quickly…

[Kerryd22]

The best part about this announcement is that there is a stage 1 trial actually underway right now. Usually these announcements are about raising interest and cash but we will know very soon whether it actually works in humans although the trial will run for two years (as long as it’s successful and doesn’t kill anyone!)

It’s all over the English news and Australian news today but I haven’t seen any American news reports yet. That’s not to say it’s not there but the news we want to hear out of City of Hope is whether the idea actually works outside the lab. I think we’ll have to rely upon our American friends to let us know what they’re hearing about it.

[Gingerann1 in reply to Kerryd22]

Now all over US news. Relatives and friends forwarding to me. Fingers crossed that they’re on to something for MBC and other forms of cancer. Still waiting for updates on SERA2 (formerly ErSo). Thankful that there should be more options in the pipeline.

[HoneyBadgerLady]

Haven't heard anything yet here in California. Hope it works!

[SeattleMom]

WOW!! Thanks for sharing, Kerry! 💗🙏🏻

[diamags]

Thank you for sharing! It is so good to see so many lines of research. It proves that they really are trying to find a cure!

[mariootsi]

Thank you for the info.