genetic testing and circulating cell free dna

[Sweep16]

Hi lovely ladies

Just want to say how extremely helpful and supportive this website is.

I’m a nutshell my history is breast cancer grade 1, back in December 2001. Mastectomy, chemotherapy, radiotherapy plus 15 yrs of oestrogen suppressing medication. 2022 big shock, mets in bones, liver & lungs. On ibrance 100g & letrazole. First scan showed a good reduction everywhere.

Obviously things have moved on enormously since my initial diagnosis in 2001. My question is has anyone gone down the path of genetic testing and circulating cell free dna?

Any advice?

Thank you

[GollyG]

Hi there,

I haven't had such testing but am certainly interested in it. I read an article recently by someone in cancer research in the UK saying every cancer patient should have their individual cancer profiled in this way so as to target treatment more effectively and not have people run the gamut of lines of treatment that were never going to work. I agreed to a double blind clinical trial this summer and as a consequence found out I have ERS1 mutation which is probably good to know - means letrozole not doing its thing for me anymore. Hoping I'm getting the oral SERD trial drug...

Good luck with it all,

Gill

[Sweep16 in reply to GollyG]

Interesting thanks for replying

Good luck to you too

[AvidBooklover]

Definitely do the testing. It will identify the next drug(s) that could work for you. I did Oncotype when first diagnosed in 2012 and the another genetic test in 2019 with recurrence

[Sweep16 in reply to AvidBooklover]

Thank you 🙏