Does anyone know anything about the treatment of very low estrogen positive MBC? I was on arimidex for three years before my MBC was diagnosed, and during that time the ER went down from 99 percent to 2 percent. I have been put on ibrance and faslodex. I know this treatment is designed for ER positive tumors, and my oncologist said it is used no matter what the positivity rate. But my question is, is it likely to work?
I have done one full month of ibrance. I had to stay off it for an extra week because I was neutropenic, and then I was off for another extra week because it takes five days to get my test results to me, and by that time someone close to me was sick, and I did a covid test. So I have done three weeks on, three weeks off, and now I'm a week and a half back on. My tumor is on my clavicle, so it's palpable, and believe me, I palpate it all the time. It does not seem to have changed at all. Should it have? How long does it take to start showing results? I'm just concerned that the low estrogen receptor levels will make it all for nothing.
And then what?