Treatment path after Ibrance in the U.K.

[TE53_67]

dear all those U.K. ladies

my MBC is ER and PR positive and hers negative with mets in the lungs. I wanted to understand from the U.K. ladies what treatment path you went on to after Ibrance failed . I would love to hear your stories

Hugs and strength

[LDR1]

Hi TE, I not in the UK but can reply on my post-Ibrance steps. Ibrance + Fulvestrant was my first line of treatment after MBC diagnosis and I was on it for 18 months, with a great initial response. After that a scan showed progression so I had surgery, which required some time off meds both before & after, then went on Verzenio (one of the other CDK4-6 meds - while they have a similar mechanism of action, some docs feel they are different enough that you can try another) still with Fulvestrant. I was only on that 2.5 months before another scan showed more progression, so we abandoned all CDK4-6’s and now I’m on Xeloda (only that, no more Fulvestrant). Hope that helps! Wishing you the best.

[TE53_67 in reply to LDR1]

thanks - very much so. Similar to what I read on line re CDK 4/6 and them being similar but possibly having different impacts one following another

Hugs xx

[Glas0824]

I’m in uk and after 3 1/2 years on leterzol and Ibrance had progression then went on to fulvesterant that had no impact . Thankfully we picked quickly ( three mknths) that it wasn’t working . Now on capcitamine for four months- last scan showed significant improvement and side effects manageable- hoping for long time on this!

[Partia]

I live in the United States and I've been on iBrance for 6 years in 6 months along with letrazole. It hasn't really given me bad side effects except my hair is ugly and straggly and I don't have any eyebrows.

[stardust1965]

I have mets to my bones only but you can see my treatment history from my bio - just click on my name.

I am currently on Capecitabine but looks likely I’ll be moving on to IV chemotherapy for the first time very soon.

[susiemarmite]

in london. Ibrance failed for me too. After kisqali had failed. I’m now on Xeloda (capecitabine).

[Jessie55]

Hi from the UK. My sister in law went to Piqray after Ibrance and Exemesane. NICE guidelines are worth looking into if you haven't already. Maybe we don't have as much flexibility here as in the US re lines of treatment. Would love to know myself. good luck

[TE53_67]

thanks … yea that what worries me. Seems like cape or IV chemo is the next step. Worries me a lot 🥲

[Travellady]

Hi te, I'm from the UK under NHS and after Ibrance + letrozole, I was put on Afinitor + Aromasin.Unfortunately had to come off Afinitor due to rare side effect of pneumonitis so stayed on just Aromasin until that failed recently.

My options were then to go onto Xelado, fulvestrant or piqray + fulvestrant. You have to be tested for the PIK3CA gene if piqray is an going to be an option and this has to be done on the tumour biopsy (the blood option for this test isn't available on the NHS).

I didn't have the gene, so choose to go onto Xelado and leave the fulvestrant in case a better oral type of fulvestrant comes into a later treatment option.

So you still have some extra options to go before proper chemo.

Hope that helps 🙂

[TE53_67]

thank you so much - I think that’s what we all need and want are options you have calmed me this morning xxxx