I was diagnosed with mbc after a 3cm tumor was found in chest - crushing my SVC which then led to stents required to fix that. That was found Jun 2017. Radiation destroyed the tumor as of Aug 2017 and I was put on Ibrance and Faslodex. White counts suffered so was reduced from 125 to 100 to 75mg Ibrance. As of Sep 2018 markers began to rise, and not fall as they have for past year. Numbers are low - only 40 when active cancer found. No at 96 and 107 (15 & 27.29). White counts improved so doc agreed to increase Ibrance now to 100mg but still no change in TM. 3 PET scans, as recent as 12/16/18 do not show anything. So frightening that the numbers continue to rise but scans show nothing. This month they asked about possible headaches, dizzyness, etc... leading to brain of course. Thankfully, I insisted on brain MRI when this all began as I know PETs can't scan brain. And thankfully, I have no symptoms that would suggest METS to brain. Question is - why are the numbers going up? Was 5pts/mo, then 10, and this month jumped almost 20pts. Docs say they'll wait one more mo and then order PET in Apr vs Jun as scheduled. Meanwhile, everyone is mystified and I'm of course on high alert! Has anyone else had this happen?