I was diagnosed last July with Met Breast Cancer of the Liver. I have been taking IBrance and Letrozole since August. The lastest MRI in November showed some improvement. My latest labs in December showed some increase in my liver enzymes. Now I'm afraid the drugs are not working. I'm up and moving daily, working, jogging 3 - 5 miles 4 days a week. so far my quality of life is great. I've been praying that there is another drug to take in case my current regime proves to not be working. And I hope for a drug that allows my to continue enjoying this wonderful world. If the enzymes don't improve in 6 weeks I will have an MRI. The stress and the waiting is awful. Prayers for everyone who is suffering.