Trouble with trazadone

[ziggypiggy]

Third go around trying trazadone for chronic depression and sleep. Never made it past a few days the first two attempts after severe headaches. This time around I titrated from near nothing up to 50mg. Unfortunately at 50mg trazadone sets my RLS ablaze. It's always been touted as a "safe" antidepressant for those of us with RLS. After my experience recenty, I scoured the interwebs and found plenty of anecdotal evidence from users with a similar experience. I did also find users who did not experience an increase in RLS symptoms. More disappointed than surprised. We all respond differently to medications so I get it. I just didnt expect for it to be one of the worst antidepressants for my RLS that I've tried. I hope it works well for others. For me the quest continues.

[SueJohnson]

You might want to try tianeptine (Stablon, Coaxil). If so let us know how it goes.

[ChrisColumbus]

DesertOasis also reported RLS symptoms got worse on 50mg of trazodone (Molipaxin, Desyrel, Trittico) which only stopped after she came off:

healthunlocked.com/rlsuk/po....

[Irmajs]

Doesn’t seem to bother me. I take with my CBD. It does help me go to sleep.

[67Waterman]

I am so so sorry to hear that ... for me, I take 150mg Trazadone nightly and it helps with depression and does not "kick off" my RLS - but it is certainly good to learn from you that it is not the miracle that I thought it was. Good luck with finding something that suits you - both depression and RLS are horrible things to have. x

[daisydaisy26]

my mom was very dizzy on it too, unfortunately, to the point of nearly falling, so for now she had to quit it. Cymbalta did help with depression, but RLS was intense.

[BocaMom]

Unfortunately trazodone gives me severe nasal stuffiness which certainly doesn’t help me sleep lol.

[ziggypiggy in reply to BocaMom]

That's what happened to me the first couple of times trying trazadone. The headache and stuffiness were not an issue this last time trying it. So odd.

[BocaMom in reply to ziggypiggy]

Wow that's interesting. Maybe someday I will revisit.

[Rappinrocks21]

I have ALWAYS had severe RLS symptoms with any anticholinergic (dries you up) medication, like this or the obvious ones like Benadryl.

[Westann]

I take 200mg of trazodone at bedtime, for depression and insomnia. It seems to help with both with no significant side-effects. It's so frustrating that all of these medications affect us each so differently. My doctor was willing to prescribe trazodone, after I supplied her with some documentation about RLS and medication. However, I'm not sure she would be willing to experiment with different meds until we found the right solution for me. It's sad really that I feel grateful she listened to me at all regarding my RLS.

[SueJohnson in reply to Westann]

Are you still taking gabapentin? Did your ever have your ferritin checked?

[ziggypiggy in reply to SueJohnson]

Yes. Still taking gabapentin. It helps with my physical anxiety throughour the day. I'm do for my yearly ferritin test soon. Always have had good high numbers.

[ChrisColumbus]

Welcome to the forum: please see this Pinned post linked below about completing your profile, and please also note the section within that Post about Augmentation. Most RLS sufferers on dopamine agonists such as pramipexole eventually experience this:

healthunlocked.com/rlsuk/po...

[SueJohnson in reply to ChrisColumbus]

LOL - who are you welcoming to the forum?😀

[ChrisColumbus in reply to SueJohnson]

Odd. Someone who in their first post here recommended pramipexole in this chain, but their post has now disappeared, presumably deleted. Kaarina also noticed them and liked my post. 2islandboy also responded to them (below). 🤷‍♂️

[SueJohnson in reply to ChrisColumbus]

Ahh - I wondered about 2islandboy's post.

[Amrob]

Ziggypiggy it sounds as though you have tried a number of different antidepressants. About 2 years ago, I tried transcranial magnetic stimulation for my PLMD. Most of the people in the clinic were being treated for depression. I understand it can be very effective for intractable depression.

[ziggypiggy in reply to Amrob]

I tried that several years sgo. No luck. Thanks for the suggestion though.

[2islandboy]

Please DON'T suggest pramipexole to people on this blog. It is lethal. Just wait til you augment!