Trouble with trazadone : Third go... - Restless Legs Syn...

Restless Legs Syndrome

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Trouble with trazadone

ziggypiggy profile image
19 Replies

Third go around trying trazadone for chronic depression and sleep. Never made it past a few days the first two attempts after severe headaches. This time around I titrated from near nothing up to 50mg. Unfortunately at 50mg trazadone sets my RLS ablaze. It's always been touted as a "safe" antidepressant for those of us with RLS. After my experience recenty, I scoured the interwebs and found plenty of anecdotal evidence from users with a similar experience. I did also find users who did not experience an increase in RLS symptoms. More disappointed than surprised. We all respond differently to medications so I get it. I just didnt expect for it to be one of the worst antidepressants for my RLS that I've tried. I hope it works well for others. For me the quest continues.

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ziggypiggy
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19 Replies
SueJohnson profile image
SueJohnson

You might want to try tianeptine (Stablon, Coaxil). If so let us know how it goes.

ChrisColumbus profile image
ChrisColumbus

DesertOasis also reported RLS symptoms got worse on 50mg of trazodone (Molipaxin, Desyrel, Trittico) which only stopped after she came off:

healthunlocked.com/rlsuk/po....

Irmajs profile image
Irmajs

Doesn’t seem to bother me. I take with my CBD. It does help me go to sleep.

67Waterman profile image
67Waterman

I am so so sorry to hear that ... for me, I take 150mg Trazadone nightly and it helps with depression and does not "kick off" my RLS - but it is certainly good to learn from you that it is not the miracle that I thought it was. Good luck with finding something that suits you - both depression and RLS are horrible things to have. x

daisydaisy26 profile image
daisydaisy26

my mom was very dizzy on it too, unfortunately, to the point of nearly falling, so for now she had to quit it. Cymbalta did help with depression, but RLS was intense.

BocaMom profile image
BocaMom

Unfortunately trazodone gives me severe nasal stuffiness which certainly doesn’t help me sleep lol.

ziggypiggy profile image
ziggypiggy in reply toBocaMom

That's what happened to me the first couple of times trying trazadone. The headache and stuffiness were not an issue this last time trying it. So odd.

BocaMom profile image
BocaMom in reply toziggypiggy

Wow that's interesting. Maybe someday I will revisit.

Rappinrocks21 profile image
Rappinrocks21

I have ALWAYS had severe RLS symptoms with any anticholinergic (dries you up) medication, like this or the obvious ones like Benadryl.

Westann profile image
Westann

I take 200mg of trazodone at bedtime, for depression and insomnia. It seems to help with both with no significant side-effects. It's so frustrating that all of these medications affect us each so differently. My doctor was willing to prescribe trazodone, after I supplied her with some documentation about RLS and medication. However, I'm not sure she would be willing to experiment with different meds until we found the right solution for me. It's sad really that I feel grateful she listened to me at all regarding my RLS.

SueJohnson profile image
SueJohnson in reply toWestann

Are you still taking gabapentin? Did your ever have your ferritin checked?

ziggypiggy profile image
ziggypiggy in reply toSueJohnson

Yes. Still taking gabapentin. It helps with my physical anxiety throughour the day. I'm do for my yearly ferritin test soon. Always have had good high numbers.

ChrisColumbus profile image
ChrisColumbus

Welcome to the forum: please see this Pinned post linked below about completing your profile, and please also note the section within that Post about Augmentation. Most RLS sufferers on dopamine agonists such as pramipexole eventually experience this:

healthunlocked.com/rlsuk/po...

SueJohnson profile image
SueJohnson in reply toChrisColumbus

LOL - who are you welcoming to the forum?😀

ChrisColumbus profile image
ChrisColumbus in reply toSueJohnson

Odd. Someone who in their first post here recommended pramipexole in this chain, but their post has now disappeared, presumably deleted. Kaarina also noticed them and liked my post. 2islandboy also responded to them (below). 🤷‍♂️

SueJohnson profile image
SueJohnson in reply toChrisColumbus

Ahh - I wondered about 2islandboy's post.

Ziggypiggy it sounds as though you have tried a number of different antidepressants. About 2 years ago, I tried transcranial magnetic stimulation for my PLMD. Most of the people in the clinic were being treated for depression. I understand it can be very effective for intractable depression.

ziggypiggy profile image
ziggypiggy in reply to

I tried that several years sgo. No luck. Thanks for the suggestion though.

2islandboy profile image
2islandboy

Please DON'T suggest pramipexole to people on this blog. It is lethal. Just wait til you augment!

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