Nausea and Trazadone

[keiralee]

Hi, I have been suffering from almost constant nausea for a couple of months or more. My GP has arranged every test available and nothing points to anything that could contribute to the nausea. I'm trying g to go through things one by one starting with the Trazadone which I take to combat insomnia and depression associated with Buprenorphine.

Has anyone suffered from nausea with this drug and could it be that the Trazadone and the Buprenorphine are reacting against each other.

Any comments would be appreciated

[SueJohnson]

Both can cause nausea. I would recommend Kytril (Sustol, Granisetron, Sancuso), Anzemet (Dolasetron), Zofran (ondansetron). Zofran is best but can be hard to get in the UK.

[keiralee in reply to SueJohnson]

Hi Sue, I have tried Granisetron and Ondasetron and neither have helped. Thank you for your thoughts

[Joolsg]

I suffered crippling nausea on Buprenorphine. I was literally bedbound for a week and lost 7 pounds. Horrendous.My GP was unable to prescribe zofran but my MS neurologist instantly agreed. However, before I started it, I used my medical cannabis oil with 20% THC as I had a 'lightbulb' moment, remembering that chemo patients use it when zofran fails.

Sure enough, the cannabis oil worked the first night I took it. I used 0.3ml of oil for a week, then reduced to 0.1ml for a week. When I stopped at week 3, the nausea was gone.

You would only need to buy a month's worth of medical cannabis. It would cost you £50 for the private clinic consultation and around £3 a day for the cannabis oil.

Hopefully it will work.

You could then continue to take 0.1 ml for weeks/months if the nausea doesn't resolve. Cannabis helps with sleep as well.

[davchar23]

Dear Keiralee,

I successfully use buprenorphine patches to control my RLS. The main side effects are nausea and hot/cold sweats. none of the anti nausea drugs normally prescribed (as in Sue J's reply) had virtually no effect.

I have significantly reduced both side effects by staggering two half doses of the 15mcg/he patch. In other words i put on 7-5mcg patch on day one and then on day 3 I attach the other 7.5mcg patch. by doing this it seems to balance out the input of bupre into my system and significantly reduces the side effects.

I have to a lesser extent suffered depression from the bupre and my GP prescribed trazodone (100mg at night). This partially worked and my GP suggested increasing the trazodone dose with another 100mg in the morning. I tried this and the result was awful in terms of tiredness and a feeling of complete inability to do anything.

I am not sure there is a reaction between the buprenorphine and trazodone but I am reluctant to continue with the increased dose and will have to accept the reduced depression on just 100mg of trazodone at night.

I hope my comments are of interest and support.

Davchar23

[keiralee in reply to davchar23]

Thanks for replying