I noticed my RLS worsen after having Covid, but I also started to take Trazodone 25mg several times a week around this time. I doubled my iron and all was fine. Since October I’ve been taking 50mg of Trazodone every night. I have developed “sleep anxiety” whenever I have an early morning meeting, doctors appointment, etc and I know that type of anxiety is best treated with anti-anxiety meds, not sleeping pills. It was great in terms of sleep anxiety and even my dreams were more normal and actually had color in them, whereas they haven’t in a long time. My RLS ratcheted up as well as my very mild peripheral neuropathy/small fiber neuropathy. I didn’t make the connection until Sunday of this week and stopped the Trazodone. Last night everything was somewhat better. The real test will be going back down to 28mg of ferrous bisglycinate.
Anyways, I did research and there are numerous case reports of Trazodone triggering RLS. I know that it raises serotonin, yet believed it was somehow offset by raising/analtering other neurotransmitters. Whatever affect it has on blocking the uptake of serotonin it supposedly has 100x that affect on 5ht2a. So it is an 5ht2a antagonist similar to Quetiapine, which I guess some of us can handle and some can’t. Only Wellbutrin has no effect on serotonin and instead raises dopamine and norepinephrine. I should know better. Whenever you google a substance, and it talks about raising serotonin, or blocking its uptake, it should be put on the no list, no matter what the RLS experts say, so I think.
Trazodone, RLS, and pregnancy 
Venting about a poor night, again and no relief in sight
Hello again, anything about antacids?
Question about Quinine 
Worries about Gabapentin 
